Produk Pekerti-Aa

Aditi, Bunga

doi:10.31227/osf.io/qx8se

Cited by 10 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The human Gle1 gene encodes two distinct isoforms-Gle1A and Gle1B-that modulate SG formation and mRNA export at the nuclear pore complex, respectively [586,587]. When Gle1A is recruited to SGs in the cytoplasm during stress, it becomes a critical modulator of translation that can ultimately affect SG dynamics, assembly, and disassembly by controlling how DDX3X binds to RNA [585,588]. In SGs, DDX3X is the gate-keeper that can either promote translation via RNA binding or suppress translation as a result of excess RNA binding.…”

Section: Gsk-3 Phosphorylation Of Gle1a Mediates Stress Granule Disas...mentioning

confidence: 99%

Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19

Loh¹,

Reíter

2022

IJMS

View full text Add to dashboard Cite

The relentless, protracted evolution of the SARS-CoV-2 virus imposes tremendous pressure on herd immunity and demands versatile adaptations by the human host genome to counter transcriptomic and epitranscriptomic alterations associated with a wide range of short- and long-term manifestations during acute infection and post-acute recovery, respectively. To promote viral replication during active infection and viral persistence, the SARS-CoV-2 envelope protein regulates host cell microenvironment including pH and ion concentrations to maintain a high oxidative environment that supports template switching, causing extensive mitochondrial damage and activation of pro-inflammatory cytokine signaling cascades. Oxidative stress and mitochondrial distress induce dynamic changes to both the host and viral RNA m6A methylome, and can trigger the derepression of long interspersed nuclear element 1 (LINE1), resulting in global hypomethylation, epigenetic changes, and genomic instability. The timely application of melatonin during early infection enhances host innate antiviral immune responses by preventing the formation of “viral factories” by nucleocapsid liquid-liquid phase separation that effectively blockades viral genome transcription and packaging, the disassembly of stress granules, and the sequestration of DEAD-box RNA helicases, including DDX3X, vital to immune signaling. Melatonin prevents membrane depolarization and protects cristae morphology to suppress glycolysis via antioxidant-dependent and -independent mechanisms. By restraining the derepression of LINE1 via multifaceted strategies, and maintaining the balance in m6A RNA modifications, melatonin could be the quintessential ancient molecule that significantly influences the outcome of the constant struggle between virus and host to gain transcriptomic and epitranscriptomic dominance over the host genome during acute infection and PASC.

show abstract

Section: Gsk-3 Phosphorylation Of Gle1a Mediates Stress Granule Disas...mentioning

confidence: 99%

Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19

Loh¹,

Reíter

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…NiV outbreaks have also been reported in India, with the largest one being in Siliguri, West Bengal in 2001 (around 66 cases and 45 deaths) and a smaller outbreak with five cases and a 100% fatality rate reported in 2007 in Nadia district, West Bengal [9]. These outbreaks occurred across the border from the Nipah belt in Bangladesh; however, recently, in 2018, a NiV outbreak occurred in the Kozhikode and Malappuram districts of Kerala, a region in South India which is geographically disconnected from the areas affected by previous outbreaks [10]. In 2019, a single NiV case was identified in Kerala's Ernakulum district.…”

Section: Henipaviruses: a Cause Of Grave Concernmentioning

confidence: 99%

Nipah and Hendra Viruses: Deadly Zoonotic Paramyxoviruses with the Potential to Cause the Next Pandemic

et al. 2022

View full text Add to dashboard Cite

Nipah and Hendra viruses are deadly zoonotic paramyxoviruses with a case fatality rate of upto 75%. The viruses belong to the genus henipavirus in the family Paramyxoviridae, a family of negative-sense single-stranded RNA viruses. The natural reservoirs of NiV and HeV are bats (flying foxes) in which the virus infection is asymptomatic. The intermediate hosts for NiV and HeV are swine and equine, respectively. In humans, NiV infections result in severe and often fatal respiratory and neurological manifestations. The Nipah virus was first identified in Malaysia and Singapore following an outbreak of encephalitis in pig farmers and subsequent outbreaks have been reported in Bangladesh and India almost every year. Due to its extreme pathogenicity, pandemic potential, and lack of established antiviral therapeutics and vaccines, research on henipaviruses is highly warranted so as to develop antivirals or vaccines that could aid in the prevention and control of future outbreaks.

show abstract

“…While neutralizing antibodies elicited by vaccines are thought to be highly specific and effective, purified antibodies from convalescent serum could be equally efficacious when used in passive immunization, and have been explored as antiviral strategies against henipaviruses. A cross-reactive human monoclonal antibody (m102.4) was developed and has been shown to have a neutralizing effect for both NiV and HeV, in vitro and in vivo [126]. NiV and HeV infection starts with the viral G protein attaching to the host cell receptor (ephrin-B2 or -B3), which then triggers conformational changes to enable the viral F protein to interact and fuse with the host cell membrane [31,48].…”

Section: Therapeutics and Vaccines-host And Immune Responsesmentioning

confidence: 99%

The Immunobiology of Nipah Virus

et al. 2022

View full text Add to dashboard Cite

Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that emerged in Malaysia in 1998. It is a human pathogen capable of causing severe respiratory infection and encephalitis. The natural reservoir of NiV, Pteropus fruit bats, remains a continuous virus source for future outbreaks, although infection in the bats is largely asymptomatic. NiV provokes serious disease in various mammalian species. In the recent human NiV outbreaks in Bangladesh and India, both bats-to-human and human-to-human transmissions have been observed. NiV has been demonstrated to interfere with the innate immune response via interferon type I signaling, promoting viral dissemination and preventing antiviral response. Studies of humoral immunity in infected NiV patients and animal models have shown that NiV-specific antibodies were produced upon infection and were protective. Studies on cellular immunity response to NiV infection in human and animal models also found that the adaptive immune response, specifically CD4+ and CD8+ T cells, was stimulated upon NiV infection. The experimental vaccines and therapeutic strategies developed have provided insights into the immunological requirements for the development of successful medical countermeasures against NiV. This review summarizes the current understanding of NiV pathogenesis and innate and adaptive immune responses induced upon infection.

show abstract

Produk Pekerti-Aa

Abstract: Produk pekerti AA ini menyajikan materi laporan mengenai Analisis Instruksional, Struktur Pembelajaran, Kontrak Kuliah, . Silabus Mata Kuliah, Rencana Program Pembelajaran (RPP), Media Pembelajaran, Bahan Ajar

Cited by 10 publications

References 0 publications

Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19

Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19

Nipah and Hendra Viruses: Deadly Zoonotic Paramyxoviruses with the Potential to Cause the Next Pandemic

The Immunobiology of Nipah Virus

Contact Info

Product

Resources

About