Products of lipid peroxidation and changes in sulfhydryl compounds in pancreatic tissue of rats with caerulein-induced acute pancreatitis

Dâbrowski, A; Gabryelewicz, A; Chwiecko, M.

doi:10.1016/0885-4505(91)90045-m

Cited by 7 publications

(3 citation statements)

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“…The depletion of antioxidant systems in pancreatitis has been investigated in the caerulein model [47,48]. Depletion of non-protein sulphydryls, roughly equivalent to GSH depletion, was followed by an increase in lipid peroxidation products and depletion of protein thiols [47].…”

Section: Glutathione Depletion Reactive Oxygen Species and Acute Pamentioning

confidence: 99%

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Xenobiotic Metabolism, Oxidant Stress and Chronic Pancreatitis

Wallig

1998

Digestion

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Chronic pancreatitis, although relatively rare in the Western World, is common in certain tropical zones where staple crops such as cassava are rich in cyanogenic glycosides. This paper reviews the evidence for a cyanide connection, with reference to experimental studies using another plant nitrile, crambene; and then examines the hypothesis that chronic pancreatitis represents a manifestation of uncoordinated detoxification reactions between pancreatic cytochrome P450 mono-oxygenases and phase II conjugating enzymes, resulting in the irreversible consumption of glutathione in the acinar cell. The conclusion is that the central role of disrupted pancreatic glutathione status, as a result of ‘xenobiotic stress’, in the evolution of chronic pancreatitis cannot be overestimated. This position contrasts with that in acute pancreatitis, in which glutathione depletion has a pivotal role too, but occurs as a result of ‘stress’ from reactive oxygen species.

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Section: Glutathione Depletion Reactive Oxygen Species and Acute Pamentioning

confidence: 99%

“…Depletion of non-protein sulphydryls, roughly equivalent to GSH depletion, was followed by an increase in lipid peroxidation products and depletion of protein thiols [47]. The inhibition of GGT by the inhibitor AT-125 has been observed to exacerbate the GSH depletion [41,48].…”

Section: Glutathione Depletion Reactive Oxygen Species and Acute Pamentioning

confidence: 99%

Xenobiotic Metabolism, Oxidant Stress and Chronic Pancreatitis

Wallig

1998

Digestion

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show abstract

“…En el epitelio pigmentario retiniano, la catepsina D (la principal proteasa lisosomal) se deslocaliza hacia el espacio extracelular, probablemente por la acumulación de productos de peroxidación lipídica (complejos lípido-proteína dañados oxidativemente)(Hoppe et al, 2004). Se sabe que en la PA inducida porDiscusión 149 ceruleína, ocurren procesos de peroxidación lipídica y unión covalente de 4hidroxialquenales a los grupos sulfhidrilo de las proteínas del tejido pancreático(Dabrowski et al, 1999, Dabrowski et al, 1991. Las proteínas LAMP contienen diferentes residuos conservados de cisteína que, en condiciones normales, forman los cuatro puentes disulfuro presentes en la parte intralisosomal(Fukuda, 1991).…”

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