One of the main tasks of animal husbandry is the proper rearing of replacement young animals on diets that meet feeding standards for all elements of a detailed nutrition system. However, the nutritional value of animal feeding does not always correspond to the required norms. Having a high antibacterial, immunostimulating, immunomodulating eff ect, extracts of various vegetative organs of plants are used to treat many diseases of contagious and non-contagious etiology, for the prevention of parasitic diseases, and the healing of wound surfaces. Containing biofl avonoids and other biologically active components, they increase feed intake by animals, its digestibility, and nutrient conversion, improve product quality, and reduce feed costs for its production. The purpose of the research was to establish the infl uence of the phyto and mineral complex and the enzyme Glucolux F in the diets of calves during the preweaning period on metabolic processes in their bodies and productivity when used separately and together. When rearing calves on the basic diet were consumed per unit of live weight gain 4,15 energy feed units and 506 g of digestible protein, with the addition of the phyto and mineral complex feed consumption decreased by 1,2–1,8 %, with the Glucolux F enzyme by 1,9–3,1 %, and when they were used together by 0,5–4,6 %. At the same time, in the 4th experimental group there was the highest total live weight gain by 25,29 kg, which exceeded the 1st control group by 4,8 %, the 2nd experimental group by 3,0 and the 3rd experimental group by 1,6 %. The level of profi tability of live weight production of calves was higher in the 2nd experimental group by 2,3 abs.%, in the 3rd experimental group by 3,8 abs.% and in the 4th experimental group by 5,3 abs.% than in the 1st control group. The use of a phyto and mineral complex of biogenic microelements 100 ml/animal/day and the enzyme Glucolux F at a dose of 0,50 kg/t of compound feed in the diet of calves during the preweaning period, both separately and together, made it possible to increase the productivity of animals and the level of profi tability of production. The best results were obtained when using them together.