Productive and perceptive language reorganization in temporal lobe epilepsy

Thivard, Lionel; Hombrouck, Jérémie; Montcel, Sophie Tézenas du; Delmaire, Christine; Cohen, Laurent; Samson, Séverine; Dupont, Sophie; Chiras, J.; Baulac, Michel; Lehericy, Stéphane

doi:10.1016/j.neuroimage.2004.10.001

Cited by 141 publications

(145 citation statements)

References 52 publications

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“…The reduced left hemisphere predominance suggests a tendency for bilateralization with supplementary involvement of the right hemisphere (Springer et al 1999;Adcock et al 2003). Other studies have previously shown change of the hemispheric specialization degree or pattern in patients (Pataraia et al 2004(Pataraia et al , 2005Brazdil et al 2005;Thivard et al 2005;Yuan et al 2006) with respect to healthy subjects. However, in these studies, the assessment of the left-right hemispheric difference was not statistically robust as they generally used lateralization indices calculation.…”

Section: Regions Of Interest During Rhyme Detectionmentioning

confidence: 77%

“…As suggested by other studies (Lehericy et al 2002;Ries et al 2004;Thivard et al 2005), the language reorganization should be explored at regional rather than at hemispheric level, because the reorganisation pattern depend on the region taken into account. Furthermore, the reorganisation of temporal regions occurs more frequently than the reorganisation of frontal regions.…”

Section: Cousin Et Almentioning

confidence: 99%

“…The age of seizures infl uences cerebral plasticity (HertzPannier et al 2002;Brazdil et al 2003;Liegeois et al 2004;Thivard et al 2005). Althought it is diffi cult to distinguish between neuropathological changes and normal language development (Yuan et al 2006), it is largely accepted that the age is the primary factor for predicting recovery with prognosis so far better in children under age of six.…”

Section: Age Of Seizures Onsetmentioning

confidence: 99%

“…Althought it is diffi cult to distinguish between neuropathological changes and normal language development (Yuan et al 2006), it is largely accepted that the age is the primary factor for predicting recovery with prognosis so far better in children under age of six. Thus, under the age of six, the language plasticity is refl ected by supplementary involvement of the homologue hemisphere and decrease of the degree of specialization (Muller et al 1999a;Brazdil et al 2003;Liegeois et al 2004;Demonet et al 2005;Pataraia et al 2005;Thivard et al 2005;Helmstaedter et al 2006;Voets et al 2006;Yuan et al 2006). Is is also refl ected by intra-hemispheric reorganization of cerebral networks (Lazar et al 1997;Bell et al 2002;Pataraia et al 2004), meaning that regions not originally involved in a specifi c language operation, become involved after reorganization.…”

Section: Age Of Seizures Onsetmentioning

confidence: 99%

“…As the left temporal lobe is involved in language (Billingsley et al 2001;Seghier et al 2004;Gitelman et al 2005), an atypical representation (bilateral hemispheric representation or right hemispheric predominance) of the subjacent cerebral regions, could occur (Adcock et al 2003;Demonet et al 2005). Overall, when the epileptogenic zone is located within the predominant hemisphere for language, two types of cerebral reorganization have been generally described: (a) intra-hemispheric, ie, the nonaffected cerebral regions from the hemisphere where the epileptogenic zone is located in, take over language functions, for instance, the language function of the temporal region could "shift" within the frontal region of the same hemisphere, when the epileptogenic zone is situated in the temporal lobe (Bell et al 2002;Brazdil et al 2003;Pataraia et al 2004Pataraia et al , 2005Kadis et al 2007) and (b) inter-hemispheric, ie, the homologues cerebral regions situated within the nonpredominant hemisphere for language become involved in language (Hertz-Pannier et al 2002;Pataraia et al 2004Pataraia et al , 2005Breier et al 2005; Cousin et al Thivard et al 2005;Helmstaedter et al 2006). The type of reorganization may depend on many factors such as the age of seizures onset (Hertz-Pannier et al 2002;Liegeois et al 2004;Berl et al 2005;Demonet et al 2005;Goldmann and Golby 2005;Thivard et al 2005), the considered language region, temporo-parietal or frontal (Kurthen et al 1992;Hertz-Pannier et al 2002;Liegeois et al 2004;Thivard et al 2005) or the associated hippocampal sclerosis (Knecht 2004;Janszky et al 2006;Weber et al 2006).…”

Section: Introductionmentioning

confidence: 99%

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Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results

Baciu¹

2008

NDT

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The present fMRI study explores the cerebral reorganisation of language in patients with temporal lobe epilepsy, according to the age of seizures onset (early or late) and the hippocampal sclerosis (associated or not). Seven right-handed control volunteers and seven preoperative adult epileptic patients performed a rhyme decision (language condition) and a visual detection (control condition) tasks in visually presented words and unreadable characters, respectively. All patients were left hemisphere dominant for language. Appropriate statistical analyses provided the following preliminary results: (1) patients compared with healthy subjects showed lower degree of hemispheric lateralization with supplementary involvement of the right hemisphere; (2) the degree of hemispheric specialization depends on the considered region; (3) patients with early seizures show signs of temporal and parietal reorganization more frequently than patients with late onset of seizures; (4) patients with early seizures show a tendency for intra-hemispheric frontal reorganisation; (5) associated hippocampal sclerosis facilitates the inter-hemispheric shift of temporal activation. Although our patients were left hemisphere predominant for language, the statistical analyses indicated that the degree of lateralization was signifi cantly lower than in healthy subjects. This result has been considered as the indication of atypical lateralization of language.

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Section: Regions Of Interest During Rhyme Detectionmentioning

confidence: 77%

Section: Cousin Et Almentioning

confidence: 99%

Section: Age Of Seizures Onsetmentioning

confidence: 99%

Section: Age Of Seizures Onsetmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results

Baciu¹

2008

NDT

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Naming fMRI predicts the effect of temporal lobe resection on language decline

Trimmel

Graan

Gonzálvez

et al. 2019

Ann Clin Transl Neurol

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Objective: To develop language functional MRI (fMRI) methods that accurately predict postsurgical naming decline in temporal lobe epilepsy (TLE). Methods: Forty-six patients with TLE (25 left) and 19 controls underwent two overt fMRI paradigms (auditory naming and picture naming, both with active baseline conditions) and one covert task (verbal fluency). Clinical naming performance was assessed preoperatively and 4 months following anterior temporal lobe resection. Preoperative fMRI activations were correlated with postoperative naming decline. Individual laterality indices (LI) were calculated for temporal (auditory and picture naming) and frontal regions (verbal fluency) and were considered as predictors of naming decline in multiple regression models, along with other clinical variables (age at onset of seizures, preoperative naming scores, hippocampal volume, age). Results: In left TLE patients, activation of the left posterior inferior temporal gyrus during auditory naming and activation of left fusiform gyrus during picture naming were related to greater postoperative naming decline. Activation LI were the best individual predictors of naming decline in a multivariate regression model. For picture naming, an LI of higher than 0.34 gave 100% sensitivity and 92% specificity (positive predictive value (PPV) 91.6%). For auditory naming, a temporal lobe LI higher than 0.18 identified all patients with a clinically significant naming decline with 100% sensitivity and 58% specificity (PPV: 58.3%). No effect was seen for verbal fluency. Interpretation: Auditory and picture naming fMRI are clinically applicable to predict postoperative naming decline after left temporal lobe resection in individual patients, with picture naming being more specific. 2186

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