Production, processing and small animal PET imaging of titanium-45

Vāvere, Amy L.; Laforest, Richard; Welch, Michael J.

doi:10.1016/j.nucmedbio.2004.10.003

Cited by 41 publications

(55 citation statements)

References 14 publications

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“…This research performed a direct labeling of apotransferrin with 45 Ti and studied the resultant biodistribution. The microPET images provided indications on the increased uptake of 45 Ti-transferrin in tumors, with retention up to 24 h, demonstrating that titanium radiopharmaceuticals could be explored as new tools for the in vivo imaging of tumors [31]. This data also supports the use of 45 Ti-labeled compounds in theranostics and personalized medicine, taking the ability to select patients for a specific type of treatment into account.…”

Section: Mean Beam Energy (Mev)supporting

confidence: 53%

“…Despite other considerations, it was reported that the cyclotron production and purification of 45 Ti is feasible. The work also demonstrated a clear spatial resolution observed down to a rod diameter of 1.25 mm using a Derenzo phantom, i.e., a resolution comparable with 18 F, only with a slight degradation due to the higher energy endpoint and consequent range widening of positrons emitted by 45 Ti (see Figure 2) [31]. Some years later, the same group reported the use of other 45 Ti-labeled compounds, namely 45 TiOCl2 and 45 TiO-phytate, as potential colloid agents for imaging the reticuloendothelial system.…”

Section: Mean Beam Energy (Mev)mentioning

confidence: 73%

“…After a gap of some years, Vavere et al [31] reported an evaluation study of 45 Ti as a radionuclide for PET imaging. Despite other considerations, it was reported that the cyclotron production and purification of 45 Ti is feasible.…”

Section: Mean Beam Energy (Mev)mentioning

confidence: 99%

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Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

et al. 2018

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Positron emitting radionuclides are used to label different compounds, allowing the study of the major biological systems using PET (positron emission tomography) imaging. Although there are several radionuclides suited for PET imaging, routine clinical applications are still based on a restrict group constituted by 18 F, 11 C, and, more recently, 68 Ga. However, with the enlarged availability of low-energy cyclotrons and technical improvements in radionuclide production, the use of unconventional radionuclides is progressively more common. Several examples of unconventional radionuclides for PET imaging are being suggested, and 45 Ti could be suggested as a model, due to its interesting properties such as its abundant positron emission (85%), reduced positron energy (β + endpoint energy = 1040 keV), physical half-life of 3.09 h, and interesting chemical properties. This review aims to introduce the role of cyclotrons in the production of unconventional radionuclides for PET imaging while using 45 Ti as an example to explore the potential biomedical applications of those radionuclides in PET imaging.

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Section: Mean Beam Energy (Mev)supporting

confidence: 53%

Section: Mean Beam Energy (Mev)mentioning

confidence: 73%

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Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

et al. 2018

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“…Vāvere et al [13] could show that the image quality using 45 Ti is comparable to that using fluorine-18.…”

Section: Introductionmentioning

confidence: 96%

Positron and γ-ray intensities in the decay of ⁴⁵Ti

Kuhn¹,

Schölten²,

Spahn³

et al. 2015

Radiochimica Acta

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Abstract:To evaluate the PET-imaging properties of the promising positron emitter 45 Ti, its + -and -ray intensities were measured. Use of the cation-exchange resin DOWEX 50W×8 (H + -form) enabled the isolation of radiochemically pure, no-carrier-added 45 Ti from "bulk" scandium after proton bombardment. Thin, no-carrier-added 45 Ti samples were prepared. The combination of -ray and X-ray spectrometry with -coincidence counting allowed for the first time the experimental determination of the positron intensity as (85.67 ± 2.23)% and the absolute intensity of the 720.22 keV -ray as (0.1171 ± 0.0057)%.

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“…Furthermore, 45 Ti is attractive as it can be made in high radionuclidic purity using naturally monoisotopic 45 Sc as a target material via the 45 Sc(p,n) 45 Ti reaction. While several publications have reported the production and extraction of 45 Ti [1][2][3], these methods rely on large ion exchange columns or solvent extraction techniques, both of which result in large final elution volumes.…”

Section: Introductionmentioning

confidence: 99%

[sup 45]Ti extraction using hydroxamate resin

Gagnon

Severin

Barnhart

et al. 2012

AIP Conference Proceedings

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Abstract.As an attractive radionuclide for positron emission tomography, this study explores the extraction and reactivity of 45 Ti produced via the 45 Sc(p,n) 45 Ti reaction on a GE PETtrace. Using a small hydroxamate column, we have demonstrated an overall recovery of >50% of 45 Ti in ~1 mL of 1M oxalic acid. Conditions for reacting with desferal were also explored, with effective specific activities up to 38 GBq/ mol obtained.

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Production, processing and small animal PET imaging of titanium-45

Cited by 41 publications

References 14 publications

Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

Positron and γ-ray intensities in the decay of ⁴⁵Ti

[sup 45]Ti extraction using hydroxamate resin

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Production, processing and small animal PET imaging of titanium-45

Cited by 41 publications

References 14 publications

Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

Positron and γ-ray intensities in the decay of 45Ti

[sup 45]Ti extraction using hydroxamate resin

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Product

Resources

About

Positron and γ-ray intensities in the decay of ⁴⁵Ti