Background Respiratory disease is one of the most important factors impacting pig production worldwide. However, the literature highlights the multitude of confounding factors complicating the clear attribution of growth impairment to respiratory disease, and the extrapolation of the effects of respiratory disease to a wider population has not been thoroughly researched. The objective of this study was to estimate the impact of respiratory disease on production performance in a subset of 56 Irish farrow-to-finish pig farms. Proxies for respiratory disease status such as serology for four major pathogens (influenza A virus, porcine reproductive and respiratory syndrome virus, Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae ), slaughter checks (pleurisy, pneumonia, lung abscesses, pericarditis and liver milk spots) and vaccination information were used as predictors for production performance. Results The models to estimate production performance from serology, slaughter checks, and vaccination were able to explain the variability of weaner and finisher mortality by 26 and 20%, respectively, and average daily feed intake (ADFI), average daily gain (ADG) and age at slaughter by 47, 40 and 41%, respectively. Feed conversion ratio and sow performance were not explained by the studied predictors. Conclusions The models fitted, especially those for ADFI, ADG and age at slaughter, emphasize the usefulness of sourcing information at different levels to understand the impact of farm health status on pig performance, and highlight the impact of respiratory disease on production performance.