Production paradigms for additive manufacturing systems: A simulation-based analysis

Avventuroso, Giuseppe; Foresti, Ruben; Silvestri, Marco; Frazzon, Enzo Morosini

doi:10.1109/ice.2017.8279987

Cited by 19 publications

(10 citation statements)

References 11 publications

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“…The selected material and its customisation address the selection of technology and the correct printing parameters for its manipulation. The process assuring the total quality improvement starts by identifying the type www.nature.com/scientificreports www.nature.com/scientificreports/ of object 27 and the quality evaluation of the results for the adopted production technology and concerns: material properties, geometric parameters, micro-porosity, the degradation of the gelled object, as well as the vitality of the cells and/or the toxicity of the material. Rapid freeze prototyping technology enables the possibility to develop high defined scaffolds and the proposed method improves the current state of the art 28,29 .…”

Section: Discussionmentioning

confidence: 99%

In-vivo vascular application via ultra-fast bioprinting for future 5D personalised nanomedicine

Foresti

Rossi

Pinelli

et al. 2020

Sci Rep

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The design of 3D complex structures enables new correlation studies between the engineering parameters and the biological activity. Moreover, additive manufacturing technology could revolutionise the personalised medical pre-operative management due to its possibility to interplay with computer tomography. Here we present a method based on rapid freeze prototyping (RFP) 3D printer, reconstruction cutting, nano dry formulation, fast freeze gelation, disinfection and partial processes for the 5D digital models functionalisation. We elaborated the high-resolution computer tomography scan derived from a complex human peripheral artery and we reconstructed the 3D model of the vessel in order to obtain and verify the additive manufacturing processes. Then, based on the drug-eluting balloon selected for the percutaneous intervention, we reconstructed the biocompatible eluting-freeform coating containing 40 nm fluorescent nanoparticles (NPs) by means of RFP printer and we tested the in-vivo feasibility. We introduced the NPs-loaded 5D device in a rat's vena cava. The coating dissolved in a few minutes releasing NPs which were rapidly absorbed in vascular smooth muscle cell (VSMC) and human umbilical vein endothelial cell (HUVEC) in-vitro. We developed 5D highresolution self-dissolving devices incorporating NPs with the perspective to apply this method to the personalised medicine.Chronic lower extremity peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis, and one of the main causes in loss of walking ability. Two treatments for lower extremity PAD are currently available: surgical (primarily bypass surgery) and endovascular treatment (EVT) mainly through balloon angioplasty. In fact, due to its clear advantages at least in the short-term, EVT represents -at present -the most common treatment for PAD 1 . Drug-Coated Balloons are made up of a semi-compliant or non-compliant balloon catheter covered with an anti-proliferative agent (typically paclitaxel), and an excipient (e.g. urea) to facilitate drug transfer into the vessel wall after balloon inflation 2 . The BASIL (Bypass Versus Angioplasty for Severe Ischemia of the Leg) trial is the only multicentre, randomised and controlled trial (RCT) which compared these two treatments 3 . One of the major limitations of this RCT is that current endovascular technologies have not been included 4 . Important advances developed in endovascular technologies address a great variety of anatomic challenges, while current and future efforts are directed towards improving long-term patency rates.The 3D printing techniques demonstrate the high potentiality of interactive processes applied to medicine and associated toxicity/vitality studies 5,6 . Materials selected for bio-printed scaffolds are predominantly based on both naturally derived polymers (including gelatine, collagen, alginate, chitosan and hyaluronic acid) or synthetic molecules (polyethylene glycol) 7-9 , allowing precise control 10 of chemical and physical properties 11 .

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Section: Discussionmentioning

confidence: 99%

In-vivo vascular application via ultra-fast bioprinting for future 5D personalised nanomedicine

Foresti

Rossi

Pinelli

et al. 2020

Sci Rep

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“…An industrial application Fig. 11 shows the tilter station of a bottling machine [17]. The tilting movement is performed by means of the cam illustrated in Fig.…”

Section: A Motion Eventsmentioning

confidence: 99%

Motion Law Assisted Design to Reduce the Vibrational Effect of Controlled Axes in Automated Machines

Silvestri¹

2019

IJRTE

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The vibrational effects created by machines moving parts is strictly related with the characteristics of the law of motion they implement, both in case of cam-follower devices and in case of servo system electronic cam controls. One of the most effective way to prevent these harmful phenomena is to limit the harmonic content of the law of motion by designing their curve as a combination of few, low frequencies, sinusoidal curves, but this often makes difficult to satisfy other functional requirements like precision points or constant speed intervals. In this work an original method to solve this problem is illustrated. It adds to the programming language CamOMiLe new functions to assist the functional design of mechanisms. The combination of the classical theory results with the flexibility of CamOMiLe building block approach makes possible to address a large number of practical applications and two examples of them are illustrated.

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“…1. This kind of machinery is largely used in food industry [3] and its optimization through simple and inexpensive solutions is of great interest for mass production lines of packaging [4], [5]. The main obstacle to the increase of productivity is given by the motion of the welding head, which is not uniform, with acceleration and deceleration to return to the starting point of the cycle after the phase of welding and cutting.…”

Section: Introductionmentioning

confidence: 99%

Dynamics Modeling and Optimization of a Wrapper Flow Pack Mechanism

Silvestri¹

2019

IJRTE

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Abstract: This paper is about a mechanical solution to vibration problem of a wrapper flow pack mechanism, which is used in packaging industry. The target mechanism is the welding head of the machine where the vibration is generated, due to eccentric masses rotating with a cut-on-the-fly motion law. Consequently, production rate is limited by the vibration at 200 pieces per minute. To reduce the vibration so that the production rate can exceed over 200 ppm, two ways of improvements are considered. The first one is optimizing the motion law. The other one consists in mechanical modifications which eliminates or balance out the inertia forces derived from the eccentric rotating mass. This research implements the second way of adding balance weights and discusses the properties of it. During analysis, the software ADAMS which provides kinematic simulation is used as the analytical tool to test and examine the solutions proposed.

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Production paradigms for additive manufacturing systems: A simulation-based analysis

Cited by 19 publications

References 11 publications

In-vivo vascular application via ultra-fast bioprinting for future 5D personalised nanomedicine

In-vivo vascular application via ultra-fast bioprinting for future 5D personalised nanomedicine

Motion Law Assisted Design to Reduce the Vibrational Effect of Controlled Axes in Automated Machines

Dynamics Modeling and Optimization of a Wrapper Flow Pack Mechanism

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