Production optimization and characterization of immunomodulatory peptides obtained from fermented goat placenta

Hou, Yinchen; Liu, Wangwang; Cheng, Yi; Zhou, Jiejing; Wu, Li; Yang, Guo‐Xun

doi:10.1590/1678-457x.6448

Cited by 11 publications

(4 citation statements)

References 26 publications

(32 reference statements)

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“…Apart from bacteria starter, yeast [ 6 , 21 , 45 , 46 ] and filamentous fungus [ 47 , 48 , 49 ] have also been used in producing bioactive peptides. Proteins can be co-cultured using a combination of different bacteria or even yeast and bacteria to accelerate the proteolytic process [ 50 ].…”

Section: Production and Processing Of Food Protein-derived Bioactimentioning

confidence: 99%

Bioactive Peptides

Daliri

Lee

2017

Foods

368

243

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The increased consumer awareness of the health promoting effects of functional foods and nutraceuticals is the driving force of the functional food and nutraceutical market. Bioactive peptides are known for their high tissue affinity, specificity and efficiency in promoting health. For this reason, the search for food-derived bioactive peptides has increased exponentially. Over the years, many potential bioactive peptides from food have been documented; yet, obstacles such as the need to establish optimal conditions for industrial scale production and the absence of well-designed clinical trials to provide robust evidence for proving health claims continue to exist. Other important factors such as the possibility of allergenicity, cytotoxicity and the stability of the peptides during gastrointestinal digestion would need to be addressed. This review discusses our current knowledge on the health effects of food-derived bioactive peptides, their processing methods and challenges in their development.

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Section: Production and Processing Of Food Protein-derived Bioactimentioning

confidence: 99%

Bioactive Peptides

Daliri

Lee

2017

Foods

368

243

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“…Antiallergenic properties are measured in vitro determining IgE content by the reverse enzyme allergosorbent, ELISA, or enzyme allergosorbent tests (Falagiani et al., ; Wigotzki, Steinhart, & Paschke, ), or in vivo by measuring indexes of spleen and thymus status, such as changes in weight, hemolysin content, changes in optical density as a result of macrophage activity, and release of histamine from mast cells (Pan et al., ). Cytotoxic activity and apoptosis have been assessed measuring cell viability and proliferation by staining, (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay, acid phosphatase assay, neutral red uptake assay, lactate dehydrogenase assay, incorporation of [ 3 H] thymine, NK assay, or JAM test (Bateman et al., ; Chalamaiah et al., ; Hagiwara, Shinoda, Fukuwatari, & Shimamura, ; Hou et al., ; Repetto, del Peso, & Zurita, ; Richardson et al., ; Rodríguez Saint‐Jean et al., ; Yang, Sinai, & Kain, ), apoptosis by the annexin V test and caspase assay (Green & Steinmetz, ; Hartmann, Wal, Bernard, & Pentzien, ), mitochondrial transmembrane potential (Hartmann et al., ; Richardson et al., ), or DNA synthesis and damage (Hsien, Ho, Lai, & Yen, ).…”

Section: Measuring the Effects Of Bioactive Peptidesmentioning

confidence: 99%

Meta‐Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability

Maestri

Pavlićević

Montorsi

et al. 2018

Comp Rev Food Sci Food Safe

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Amino acid (AA) sequences of 807 bioactive peptides from foods of animal origin were examined in order to correlate peptide structure with activity (antihypertensive, antioxidative, immunomodulatory, antimicrobial, hypolipidemic, antithrombotic, and opioid) and stability in vivo. Food sources, such as milk, meat, eggs, and marine products, show different frequencies of bioactive peptides exhibiting specific effects. There is a correlation of peptide structure and effect, depending on type and position of AA. Opioid peptides contain a high percentage of aromatic AA residues, while antimicrobial peptides show an excess of positively charged AAs. AA residue position is significant, with those in the first and penultimate positions having the biggest effects on peptide activity. Peptides that have activity in vivo contain a high percentage (67%) of proline residues, but the positions of proline in the sequence depend on the length of the peptide. We also discuss the influence of processing on activity of these peptides, as well as methods for predicting release from the source protein and activity of peptides.

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“…Food proteins from natural sources have been used to obtain a various range of bioactive peptides (Hou et al, 2014;Yoshikawa et al, 2000). Bioactive peptides usually contain short peptides (2-20 amino acid) derived from protein, but in some cases, they may consist of more than 20 amino acids (Yoshikawa et al, 2000;Kitts & Weiler, 2003).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells

Lee

Kim

2019

Food Sci. Technol

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The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fractions significantly inhibited the production of prostaglandin E 2 (PGE 2) and expression of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Furthermore, each of the WED fractions significantly decreased production of pro-inflammatory cytokine such as tumor necrosis factor-α (TNF-α) and interleukin-1β (OL-1β) (p<0.05). The fraction between 10 to 30 kDa of WED showed the highest inhibition of pro-inflammatory cytokine production, LPS-induced COX-2 expression and PEG 2 production. These results suggest that WED fractions may have the anti-inflammatory effect via the stimulus of COX-2 and TNF-α in LPS-stimulated inflammation in RAW 264.7 cells.

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Production optimization and characterization of immunomodulatory peptides obtained from fermented goat placenta

Cited by 11 publications

References 26 publications

Bioactive Peptides

Bioactive Peptides

Meta‐Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability

Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells

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