Production of β-cyclodextrin: Effect of pH, time and additives

Wadetwar, Rita N.; Upadhye, Kanchan; Bakhle, Suparna; Deshpande, Shilpa; Nagulwar, Vaishali

doi:10.4103/0250-474x.27835

Cited by 3 publications

(2 citation statements)

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“…The solubility of Lercinine was estimated with a simple, quick, and precise methods. a measured by a UV-visible spectrophotometer, was prepared in methanol, and 10 μg/ml was used as the absorption maximum [20].…”

Section: Methanolmentioning

confidence: 99%

Formulation & evaluation of cyclodextrin complexed tablets by enhancing the dissolution rate

Mandadapu¹,

Kolli²,

Kurra³

2022

J Inn App Pharma Sci

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In the present work, studies design, formulation development and evaluation of immediate release tablets of Lercanidipine inclusion complex with a view to improve its aqueous solubility, dissolution rate and oral bioavailability.The inclusion complexes of Lercanidipine were prepared with β-cyclodextrin by physical mixture, Kneading method and solvent evaporation method. The complexes were prepared in different molar ratios of drug and β-cyclodextrin namely 1:1M, 1:2M with β-cyclodextrin.The phase solubility diagram for the complex formation between Lercanidipine and β-cyclodextrin in water are AL type. Phase solubility diagram of Lercanidipine with β-cyclodextrin illustrate the solubility enhancement capacity of cyclodextrin. The aqueous solubility of Lercanidipine increased linearly (R2=0.989) as the function of β-cyclodextrin concentration. The stability constant “Kc” was found to be 164.557M-1.Invitro dissolution studies for pure drug and inclusion complexes and prepared tablets were carried out in 900 ml of 0.1N HCL using USP II paddle type dissolution apparatus.It is evident that the complex and tablets prepared were exhibited a faster dissolution when compared to pure drug dissolution data.A marked improvement in the dissolution rates observed with LK2 prepared by Kneading method. The higher dissolution rates observed with inclusion complexes and tablets prepared by Kneading may be due to better interaction of drug β- cyclodextrin. The prepared complexes were characterized by FT-IR Studies.The inclusion complex of Lercanidipinei.e.LK2 complex and F6 tablets containing LK2 complex were subjected to short-term stability studies by storing them at room temperature and at 400C and relative Humidity of 75%RH. The samples were analyzed at an interval of one week, three weeks and six weeks for their physical appearance, drug content values and dissolution profiles. No appreciable changes observed with the above parameters.

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Section: Methanolmentioning

confidence: 99%

Formulation & evaluation of cyclodextrin complexed tablets by enhancing the dissolution rate

Mandadapu¹,

Kolli²,

Kurra³

2022

J Inn App Pharma Sci

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“…Cyclodextrins (CDs) are cyclic maltooligosaccharides of 6, 7 or 8 glucose units, joined together by α-1,4 glucosidic linkages and are respectively called as α-, β-and γ-CDs. β-CDs are most commonly used carrier due to its suitable cavity diameter (7-8 A о ) for guest molecules (5). CDs act as a drug carrier to improve solubility and stability, enhancement of dissolution rate and bioavailability, reduction in volatility etc (6).…”

Section: Cyclodextrinsmentioning

confidence: 99%

Dissolution Enhancement of Drugs. Part II: Effect of Carriers

Saharan¹,

Kukka²,

Kataria³

et al. 2009

Int J Health Res

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an online international journal allowing free unlimited access to abstract and full-text of published articles. The journal is devoted to the promotion of health sciences and related disciplines (including medicine, pharmacy, nursing, biotechnology, cell and molecular biology, and related engineering fields). It seeks particularly (but not exclusively) to encourage multidisciplinary research and collaboration among scientists, the industry and the healthcare professionals. It will also provide an international forum for the communication and evaluation of data, methods and findings in health sciences and related disciplines. The journal welcomes original research papers, reviews and case reports on current topics of special interest and relevance. All manuscripts will be subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication) will be published without delay. The maximum length of manuscripts should normally be 10,000 words (20 single-spaced typewritten pages) for review, 6,000 words for research articles, 3,000 for technical notes, case reports, commentaries and short communications. Submission of Manuscript:The International Journal of Health Research uses a journal management software to allow authors track the changes to their submission. All manuscripts must be in MS Word and in English and should be submitted online at http://www.ijhr.org. Authors who do not want to submit online or cannot submit online should send their manuscript by e-mail attachment (in single file) to the editorial office below. Submission of a manuscript is an indication that the content has not been published or under consideration for publication elsewhere. Authors may submit the names of expert reviewers or those they do not want to review their papers. Enquiries

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Enzymatic conversions of starch

Tomasik

Horton

2012

Advances in Carbohydrate Chemistry and Biochemistry

117

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This article surveys methods for the enzymatic conversion of starch, involving hydrolases and nonhydrolyzing enzymes, as well as the role of microorganisms producing such enzymes. The sources of the most common enzymes are listed. These starch conversions are also presented in relation to their applications in the food, pharmaceutical, pulp, textile, and other branches of industry. Some sections are devoted to the fermentation of starch to ethanol and other products, and to the production of cyclodextrins, along with the properties of these products. Light is also shed on the enzymes involved in the digestion of starch in human and animal organisms. Enzymatic processes acting on starch are useful in structural studies of the substrates and in understanding the characteristics of digesting enzymes. One section presents the application of enzymes to these problems. The information that is included covers the period from the early 19th century up to 2009.

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Production of β-cyclodextrin: Effect of pH, time and additives

Cited by 3 publications

References 1 publication

Formulation & evaluation of cyclodextrin complexed tablets by enhancing the dissolution rate

Formulation & evaluation of cyclodextrin complexed tablets by enhancing the dissolution rate

Dissolution Enhancement of Drugs. Part II: Effect of Carriers

Enzymatic conversions of starch

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