Production of Xylaria nigripes-fermented grains by solid-state fermentation and an assessment of their resulting bioactivity

Divate, Rupesh D.; Wang, Chiun-Chuang; Chou, Su‐Tze; Chang, Chih-Wei; Wang, Peiming; Chung, Yun‐Chin

doi:10.1016/j.lwt.2017.03.017

Cited by 6 publications

(7 citation statements)

References 37 publications

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“…As the total phenolic compounds increase, the antioxidant potential of the fungi increases. This study was supported by previous studies which found that the levels of phenolic compounds resulted in their antioxidant capacity or that they correlated [35][36][37].…”

Section: Discussionsupporting

confidence: 87%

“…It is because the DPPH method has more limitations and is characterised by a lower sensitivity [34]. The antioxidant activity results in this study are better than those reported for X. nigripes, which is a traditional medicinal fungus and is a Xylaria species associated with termite nests [35]. The extracts of X. nigripes obtained from various solid-state fermentations with ethanol solvent had IC 50 values of DPPH radical scavenging activity ranged from 2.0 ± 0.1 to 2.7 ± 0.1 mg/mL.…”

Section: Discussioncontrasting

confidence: 54%

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Antioxidant Activity and Cytotoxicity against Cancer Cell Lines of the Extracts from Novel Xylaria Species Associated with Termite Nests and LC-MS Analysis

et al. 2021

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Xylaria species associated with termite nests or soil have been considered rare species in nature and the few which have been reported upon have been found to act as a rich source of bioactive metabolites. This study evaluated 10 ethyl acetate extracts of five new Xylaria species associated with termite nests or soil for their antioxidant activity, and cytotoxicity against different cancer and normal cell lines. DPPH and ABTS radical scavenging activities of the extracts demonstrated strong capacity with low IC50 values. The highest observed activities belonged to X. vinacea SWUF18-2.3 having IC50 values of 0.194 ± 0.031 mg/mL for DPPH assay and 0.020 ± 0.004 mg/mL for ABTS assay. Total phenolic content ranged from 0.826 ± 0.123 to 3.629 ± 0.381 g GAE/g crude extract which correlated with antioxidant activities. The high total phenolic content could contribute to the high antioxidant activities. Cytotoxicity was recorded against A549, HepG2, HeLa and PNT2 and resulted in broad spectrum to specific activity depending on the cell lines. The highest activities were observed with X. subintraflava SWUF16-11.1 which resulted in 11.15 ± 0.32 to 13.17 ± 2.37% cell viability at a concentration of 100 µg/mL. Moreover, LC-MS fingerprints indicated over 61 peaks from all isolates. There were 18 identified and 43 unidentified compounds compared to mass databases. The identified compounds were from various groups of diterpenoids, diterpenes, cytochalasin, flavones, flavonoids, polyphenols, steroids and derivatives, triterpenoids and tropones. These results indicate that Xylaria spp. has abundant secondary metabolites that could be further explored for their therapeutic properties.

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Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 54%

Antioxidant Activity and Cytotoxicity against Cancer Cell Lines of the Extracts from Novel Xylaria Species Associated with Termite Nests and LC-MS Analysis

et al. 2021

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“…Those changes resulted in enhanced anti-inflammatory activity of obtained extracts which was measured by the inhibition of 5-lipoxygenase and hyaluronidase [20]. Also polyphenols produced by Xylaria nigripes demonstrated enhanced anti-inflammatory properties which were verified by the inhibition of cyclooxygenase-2 [24]. Additionally, in both cases, obtained extracts demonstrated neuroprotective properties.…”

Section: Anti-inflammatory Agentsmentioning

confidence: 89%

“…There are also some fungi which could be natural sources of polyphenols: Taiwanofungus camphoratus [21], Inonotus obliquus [23], and Xylaria nigripes [24]. In all cases SSF increased their anti-inflammatory properties by increasing concentration of particular phenolic compounds which could also originate from substrates that were used for their cultivation and those were: spent substrate of Pleurotus eryngii, sunflower seed hulls, corn and rice grain, white birch and mulberry in the case of I. obliqus; wheat bran in the case of X. nigripes.…”

Section: Fungimentioning

confidence: 99%

“…There were various review papers regarding SSF but in the current chapter we focused only on selected substances which could be used in healthcare and demonstrate antimicrobial, anti-inflammatory properties or/and are immunosuppressants, anticoagulants and anticancer agents, e.g. enzymes, surfactants, terpenoids, [24] limonene-1,2-diol, α-terpineol, (−)-carvone, α-tocopherol, dihydrocarveol and valencene…”

Section: Introductionmentioning

confidence: 99%

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The Application of Solid State Fermentation for Obtaining Substances Useful in Healthcare

Wajda¹,

Januszek²

2021

Biotechnological Applications of Biomass

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In the current review we summarised the research involving solid state fermentation (SSF) for the production of compounds that could be used in healthcare (terpenoids, polyphenols, fibrinolytic enzymes, mycophenolic acid and others). We described several groups of obtained agents which hold various activity: antimicrobial, anti-inflammatory, immunosuppressive, anticoagulant and others (e.g. anticancer or anti-diabetic). It seems that especially terpenoids and polyphenols could be useful in that field, however, other substances such as enzymes and fatty acids play important role as well. We described main groups of microorganisms that are applied in SSF of those compounds, particularly Bacillus genus and fungi, and where possible provided information regarding genes involved in those processes. We also compared various approaches toward optimisation of SSF.

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Xylaria Sclerotia Formed Within Termite Nests: A Review of Their Biology and Human Uses

Hsieh,

2024

The Mycota

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Production of Xylaria nigripes-fermented grains by solid-state fermentation and an assessment of their resulting bioactivity

Cited by 6 publications

References 37 publications

Antioxidant Activity and Cytotoxicity against Cancer Cell Lines of the Extracts from Novel Xylaria Species Associated with Termite Nests and LC-MS Analysis

Antioxidant Activity and Cytotoxicity against Cancer Cell Lines of the Extracts from Novel Xylaria Species Associated with Termite Nests and LC-MS Analysis

The Application of Solid State Fermentation for Obtaining Substances Useful in Healthcare

Xylaria Sclerotia Formed Within Termite Nests: A Review of Their Biology and Human Uses

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