1988
DOI: 10.1084/jem.168.5.1539
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Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells.

Abstract: The production of TNF/cachectin by human B cell lines and tonsillar B cells was examined. Of the 15 B cell lines examined, 9 cell lines synthesize TNF mRNA constitutively. PMA stimulated most cell lines to accumulate increased amounts of TNF. SeD, 8866P, 32al, RPMI 1788, and four bone marrow-derived EBV-transformed cell lines accumulated high levels of TNF mRNA when stimulated by PMA. TNF production by these cell lines was examined. RPMI 1788 and WIH8 produced little TNF constitutively, but synthesized 5-7 ng/… Show more

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Cited by 162 publications
(50 citation statements)
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“…According to previous studies, EBV transformation of primary human B cells changes various cellular properties (23,24), such as the expression of the cell activation-associated Ag CD38 (25), and the expression of iNOS (26). Furthermore, B-LCLs have been described as expressing various cytokines with a high degree of heterogeneity (24,(27)(28)(29)(30)(31)(32). In our B-LCL, iNOS expression was detectable in highly activated CD38 ++ EBV-infected B cells, but not in CD38 + or CD38 2 B cells (Fig.…”
Section: Inos-expressing B Lineage Cells Produce Pro-and Antiinflammamentioning
confidence: 99%
“…According to previous studies, EBV transformation of primary human B cells changes various cellular properties (23,24), such as the expression of the cell activation-associated Ag CD38 (25), and the expression of iNOS (26). Furthermore, B-LCLs have been described as expressing various cytokines with a high degree of heterogeneity (24,(27)(28)(29)(30)(31)(32). In our B-LCL, iNOS expression was detectable in highly activated CD38 ++ EBV-infected B cells, but not in CD38 + or CD38 2 B cells (Fig.…”
Section: Inos-expressing B Lineage Cells Produce Pro-and Antiinflammamentioning
confidence: 99%
“…In fact, although the major source of this cytokine is macrophages (Beutler & Cerami, 1987;Aggarwel et al, 1985), the molecule can also be released by other cell types. These include monocytes stimulated by gamma interferon (Beutler & Cerami, 1987), T lymphocytes and T cell lines following stimulation with phorbol esters and anti-CD3 antibodies in different combinations (Granger & Williams, 1968;Cutri et al, 1987;Scheurich et al, 1987;Sung et al, 1988a;Turner et al, 1987), B lymphocytes (Williamson et al, 1983;Sung et al, 1988b), large granular lymphocytes (Ostensen et al, 1987;Peters et al, 1986) and mast cells (Young et al, 1987).…”
Section: General Properties Of Tnfmentioning
confidence: 99%
“…It is now known that TNF-a has diverse physiologic effects and is produced by various cell types and stimuli (18)(19)(20)(21)(22). It has been implicated as an endogenous inflammatory mediator induced by LPS (18,(22)(23)(24) or other bacterial products (I 7).…”
mentioning
confidence: 99%