Production of thermozymocidin (myriocin) by the pyrenomycete <i>Melanconis flavovirens</i>

Šašek, V.; Sailer, Miroslav; Vokoun, J.; Musílek, V.

doi:10.1002/jobm.3620290619

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…26). This α-amino fatty acid derived product is isolated from several genera of fungi, mostly by Myriococcum , 316 Melanconis 317 and Isaria . 318 It inhibits sphingosine biosynthesis by blocking the activity of serine palmitoyltransferase, which is a potent immunosuppressant with 10- to 100-fold more activity than that of immunosuppressant 94 .…”

Section: Discussionmentioning

confidence: 99%

The biosynthetic logic and enzymatic machinery of approved fungi-derived pharmaceuticals and agricultural biopesticides

Sang,

Feng,

Chi

et al. 2024

Nat. Prod. Rep.

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Section: Discussionmentioning

confidence: 99%

The biosynthetic logic and enzymatic machinery of approved fungi-derived pharmaceuticals and agricultural biopesticides

Sang,

Feng,

Chi

et al. 2024

Nat. Prod. Rep.

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Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.

et al. 1994

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Inhibition of ceramide synthesis by a fungal metabolite, myriocin, leads to a rapid and specific reduction in the rate of transport of glycosylphosphatidylinositol (GPI)‐anchored proteins to the Golgi apparatus without affecting transport of soluble or transmembrane proteins. Inhibition of ceramide biosynthesis also quickly blocks remodelling of GPI anchors to their ceramide‐containing, mild base‐resistant forms. These results suggest that the pool of ceramide is rapidly depleted from early points of the secretory pathway and that its presence at these locations enhances transport of GPI‐anchored proteins specifically. A mutant that is resistant to myriocin reverses its effect on GPI‐anchored protein transport without reversing its effects on ceramide synthesis and remodelling. Two hypotheses are proposed to explain the role of ceramide in the transport of GPI‐anchored proteins.

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Flavovirin — a new antifungal antibiotic produced by the pyrenomycete Melanconis flavovirens

Sailer

Šašek

Sejbal

et al. 1989

J. Basic Microbiol.

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The pyrenomycete Melanconis flavovirens was found to produce a mixture of two antifungal antibiotics. The first has been already described; the antibiotic is identical with thermozymocidin (myriocin). The second antibiotic is a new compound, whose isolation and identification is presented in this paper. The chemical structure of this substance (C21H37NO5) was determined to be 2-amino-2-hydroxymethyl-3,4-trans-epoxy-14-oxo-eicos-trans-6-enoic acid. After the producer it was named flavovirin and it possesses strong activity against yeasts and a moderate effectivity against filamentous fungi.

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Production of thermozymocidin (myriocin) by the pyrenomycete Melanconis flavovirens

Cited by 4 publications

References 10 publications

The biosynthetic logic and enzymatic machinery of approved fungi-derived pharmaceuticals and agricultural biopesticides

The biosynthetic logic and enzymatic machinery of approved fungi-derived pharmaceuticals and agricultural biopesticides

Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.

Flavovirin — a new antifungal antibiotic produced by the pyrenomycete Melanconis flavovirens

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