Production of the α-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species

Studies Targeting α-Glucosidase Inhibition, Antiangiogenic Effects, and Lipid Modification Regulation: Background, Evaluation, and Challenges in the Development of Food Ingredients for Therapeutic Purposes

“…Using HILIC-MS/MS, we obtained evidence of DNJ production in Bacillus subtilis DSM704. 15) In addition, we conducted a screening of 750 microorganisms, and identified Bacillus strains (Bacillus amyloliquefaciens AS385 and Bacillus subtilis B4) that produce DNJ in large quantities (Fig. 1D).…”

Biosynthesis of α-Glucosidase Inhibitors by a Newly Isolated Bacterium, Paenibacillus sp. TKU042 and Its Effect on Reducing Plasma Glucose in a Mouse Model

“…To enhance aGI production, the soybean-containing medium has been supplemented with various carbohydrates. For example, Streptomyces lavendulae GC-148 produced an aGI in medium containing 2% glucose and 1.5% soybean [8], and the Bacillus species required 4% soybean peptone supplemented with 5% carbon source (glucose, galactose, lactose, or sorbitol) [11]. In this study, Paenibacillus sp.…”

“…Soybean has been widely used in many studies as the sole source of C/N to synthesize aGIs [8,11,12,17,18]. To enhance aGI production, the soybean-containing medium has been supplemented with various carbohydrates.…”

“…So far, aGIs have been described as being produced by microorganisms, including bacteria [8,9,10,11,12,13,14,15,16] and fungi [5,17,18,19]. Among these aGIs-producing microbes, only strains of Streptomyces [8,9], bacillus [8,10,11,12,13,14], Stenotrophomonas maltrophilia [15], and Actinoplanes spp.…”

“…Among these aGIs-producing microbes, only strains of Streptomyces [8,9], bacillus [8,10,11,12,13,14], Stenotrophomonas maltrophilia [15], and Actinoplanes spp. SE-50 [16] have been studied extensively.…”