Production of Tetracycline by
            <i>Streptomyces aureofaciens</i>
            in Synthetic Media

Darken, Marjorie A.; Berenson, Herman; Shirk, Richard J.; Sjolander, Newell O.

doi:10.1128/am.8.1.46-51.1960

Cited by 39 publications

(6 citation statements)

References 15 publications

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“…Fig. (3) show the influence of the lengths of the reaction coils on the peak height. The best response was achieved at lengths of 60-cm, 60-cm, 10-cn and 0.0cm for the system.…”

Section: Physical Optimizationmentioning

confidence: 99%

“…Tetracycline is a major member of a group of antibiotics with a broad spectrum of activity, which is widely used in medicine and veterinary science to treat bacterial indications [2] . When tetracycline combined with fluid and electrolyte replacement in the treatment of cholera, effectively reduces the volume and duration of diarrhoea as well as the intravenous fluid requirement, tetracycline also rapidly eliminates the cholera vibrio from the stool of cholera patients [3,4]. The tetracyclines are a well-known and widely used as family of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

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Determination of tetracycline hydrochloride in some pharmaceutical products using flow injection spectrophotometric technique

Baban¹,

Ali²

2016

JZS

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A simple, rapid, and sensitive flow injection spectrophotometric system fordetermination of tetracycline hydrochloride (TCH) in pharmaceuticalproducts. The method is based on diazotization of 2-aminopyridine andsubsequent coupling with tetracycline hydrochloride in alkaline medium. Theformed azo-dye showed maximum absorbance at 388 nm and the calibrationcurve in the linear range of 25.0-150.0 µg/ml of tetracycline hydrochloridewith correlation coefficient 0.9988, while the detection limit was 10 µg/mland sample frequency 123 samples/hour. The accuracy and precision data fordetermination of TCH by flow injection analysis method for triplicate injectionat three concentration levels(25, 80 and 150 µg/ml) the relative standarddeviation (RSD %) are 1.04, 0.247 and 1.75%, and relative error percent (E rel )are -3.92, +1.06 and -1.9%. The proposed method was successfully applied tothe determination of tetracycline hydrochloride in pharmaceutical products.The results obtained were in good agreement with those obtained byreference method.

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“…Fig. (3) show the influence of the lengths of the reaction coils on the peak height. The best response was achieved at lengths of 60-cm, 60-cm, 10-cn and 0.0cm for the system.…”

Section: Physical Optimizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of tetracycline hydrochloride in some pharmaceutical products using flow injection spectrophotometric technique

Baban¹,

Ali²

2016

JZS

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“…For instance, about two-thirds of all antibiotics were isolated directly from or are derivatives of secondary metabolites produced by Streptomyces , the largest genus of Actinobacteria. Notable examples include daptomycin, a lipopeptide produced from Streptomyces roseosporus ; streptomycin, an aminoglycoside antibiotic from Streptomyces griseus ; and tetracycline antibiotics, produced by Streptomyces aurofaciens …”

Section: Introductionmentioning

confidence: 99%

“…Notable examples include daptomycin, a lipopeptide produced from Streptomyces roseosporus; 2 streptomycin, an aminoglycoside antibiotic from Streptomyces griseus; 3 and tetracycline antibiotics, produced by Streptomyces aurofaciens. 4 Besides Streptomyces, there are other genera that are reported less often but which also have proven the ability to produce numerous bioactive secondary metabolites. A few examples include the antibiotic erythromycin 5,6 and the insecticide spinosyn, 7 produced by Saccharopolyspora species; vancomycin 8 and epoxyquinomicins, 9 produced by Amycolatopsis species; cycloviracins 10 and kibdelomycin, 11 produced by Kibdelosporangium species; as well as arenimycins A 12 and B, 13 produced by Micromonosporaceae.…”

Section: ■ Introductionmentioning

confidence: 99%

Discovery and Characterization of Epemicins A and B, New 30-Membered Macrolides from Kutzneria sp. CA-103260

et al. 2021

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Actinobacteria have been a rich source of novel, structurally complex natural products for many decades. Although the largest genus is Streptomyces, from which the majority of antibiotics in current and past clinical use were originally isolated, other less common genera also have the potential to produce a wealth of novel secondary metabolites. One example is the Kutzneria genus, which currently contains only five reported species. One of these species is Kutzneria albida DSM 43870T, which has 46 predicted biosynthetic gene clusters and is known to produce the macrolide antibiotic aculeximycin. Here, we report the isolation and structural characterization of two novel 30-membered glycosylated macrolides, epemicins A and B, that are structurally related to aculeximycin, from a rare Kutzneria sp. The absolute configuration for all chiral centers in the two compounds is proposed based on extensive 1D and 2D NMR studies and bioinformatics analysis of the gene cluster. Through heterologous expression and genetic inactivation, we have confirmed the link between the biosynthetic gene cluster and the new molecules. These findings show the potential of rare Actinobacteria to produce new, structurally diverse metabolites. Furthermore, the gene inactivation represents the first published report to genetically manipulate a representative of the Kutzneria genus.

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“…Antibiotic resistance (AR) is prevalent in bacterial populations occurring in both natural ( 1 – 3 ) and anthropogenically altered ( 4 – 6 ) environments. Many antimicrobial compounds used therapeutically occur naturally ( 7 , 8 ), and subsequent mechanisms of resistance to them evolved long before their use as therapeutic agents to treat bacterial infections ( 9 ). It is expected that bacteria in the environment will carry antibiotic resistance genes ( 10 ); however, anthropogenic activity, including the overuse of antibiotic compounds in therapeutic and agricultural activities, has profound impacts on the evolution, geographic, and taxonomic distribution of antibiotic resistance ( 11 – 13 ).…”

Section: Introductionmentioning

confidence: 99%

Genomic Sequence Analysis of Methicillin- and Carbapenem-Resistant Bacteria Isolated from Raw Sewage

2021

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Production of Tetracycline by Streptomyces aureofaciens in Synthetic Media

Cited by 39 publications

References 15 publications

Determination of tetracycline hydrochloride in some pharmaceutical products using flow injection spectrophotometric technique

Determination of tetracycline hydrochloride in some pharmaceutical products using flow injection spectrophotometric technique

Discovery and Characterization of Epemicins A and B, New 30-Membered Macrolides from Kutzneria sp. CA-103260

Genomic Sequence Analysis of Methicillin- and Carbapenem-Resistant Bacteria Isolated from Raw Sewage

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