“…Currently, freeze‐drying (Pikal, 1994; Rey, 2016; Roy & Gupta, 2004) and spray drying (SD) (Ameri & Maa, 2006; Grasmeijer et al, 2019; S. H. Lee et al, 2011; Vehring, 2008) are two main solidification methods. Spray‐freeze drying as a recent solidification method has attracted attention since its first introduction in 1964 (Werly & Bauman, 1964), because it has advantages over classical SD and freeze‐drying. It can not only enhance the apparent solubility of poorly water‐soluble drugs, but also minimize the possibility of phase separation (Wanning et al, 2015).…”