Production of Reaginic Antibody, in Monkeys, Following Immunization with Dialyzable Constituants of Timothy Pollen Extracts

Girard, Jean‐Pierre; Hampai, A.

doi:10.1159/000230245

Cited by 5 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of primates for a model of immediate hypersensitivity in man has been reported for a long time, e.g., in the transfer of human reaginic sera to monkeys [5,6] and experimental asthma by Ascaris infection [7]. However, there are few reports about experimental pollinosis of primates [8],…”

Section: Introductionmentioning

confidence: 99%

Experimental Cedar Pollinosis in Rhesus Monkeys

Chiba¹,

Tamura²,

Koizumi³

et al. 1990

Int Arch Allergy Immunol

View full text Add to dashboard Cite

In order to develop an experimental model for human cedar pollinosis, 4 rhesus monkeys (Macaca mulatta) were subcutaneously immunized with crude cedar pollen antigen, which contained 1.0 μg or 10 μg protein with aluminium hydroxide gel, six times every month. All 4 animals showed immediate-type cutaneous reactivity. Serum IgE antibody responses against the pollen antigen, as quantitated by the Prausnitz-Küstner reaction, were seen in 3 of 4 monkeys. Radioallergosorbent test scores increased in 2 monkeys and remained at higher levels throughout the study. Histamine release from leukocytes was positive in all animals. In conjunctival provocation tests, they showed clinical signs such as eye-scratching after the antigen was dropped into their eyes. This reaction is similar to that observed in humans and suggests this animal model might be useful in studying human cedar pollinosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Experimental Cedar Pollinosis in Rhesus Monkeys

Chiba¹,

Tamura²,

Koizumi³

et al. 1990

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Some examples include mouse [1,2], rat [2,3], monkey [4], dog [5,9] and rab bit [10]. However, the spontaneous appearance of al lergic disease in animals is rare.…”

Section: Introductionmentioning

confidence: 99%

The Atopic Dog Model: Report of an Attempt to Establish a Colony

Schwartzman

Massicot

Sogn

et al. 1983

Int Arch Allergy Immunol

View full text Add to dashboard Cite

In an attempt to establish a colony of atopic dogs as a research resource, dogs with seasonal dermatitis – a reported manifestation of naturally occurring allergy in that species – were identified, acquired, and inbred. Progeny were studied during their first 2 years of life to determine if the trait could be genetically transmitted and to investigate the hypothesis that this spontaneously occurring dermatitis correlates with positive laboratory measurements for specific IgE to airborne allergens. (Serial immunoglobulin levels, including total IgE, end-point titration of histamine, and results of fecal examinations for identification of parasites were also investigated and are to be the subject of a separate publication.) Only a weak correlation between positive direct skin test results and the appearance of seasonal dermatitis was found in initial studies. Neither the results of testing by passive cutaneous anaphylaxis nor radioallergosorbent procedures correlated with positive clinical findings. Independently conducted clinical examinations and direct skin testing using selected antigens, as well as additional bronchial challenges of representative animals from the colony, also failed to furnish evidence of atopy in the dogs. Therefore, the goal of establishing an inbred line of atopic animals was not accomplished within the allotted 2-year period. Also, the data did not show a positive correlation between the seasonal dermatitis and measurements for specific IgE to airborne allergens.

show abstract