Production of reactive oxygen species by isolated mitochondria of the Antarctic bivalve Laternula elliptica (King and Broderip) under heat stress

Heise, Katja; Puntarulo, Susana; Pörtner, Hans‐Otto; Abele, Doris

doi:10.1016/s1532-0456(02)00212-0

Cited by 144 publications

(134 citation statements)

References 35 publications

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“…The resulting ROS exceed primary scavenging capacity of an organism and attack different cellular components, such as nucleic acids, cytoplasmic proteins, lipids, and membranes (Dröge, 2002;Valavanidis et al, 2006). ROS production in cells, especially in the mitochondria and peroxisome, has been found to be increased in exercised mammalian muscle, stressed bivalve gills, chicken muscles, lugworm and cultured cells as compared with non-stressed control tissue (Keller et al, 2004;Heise et al, 2003). Increase in oxidative process during high concentration of heavy metal or any other pollution related stress causes ROS accumulation, and cellular protection against such damage is achieved mainly by enzymes such as SOD, CAT, GPx or GRd (Lin et al, 2015;Das et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Change in redox state and heat shock protein expression in an Indian major carp <i>Cirrhinus cirrhosus</i> exposed to zinc and lead

et al. 2017

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-Fish are exposed to different heavy metals that may induce numerous physiological changes. In the present study, we examined the redox state in response to a severe stress resulting from two heavy metals (Zinc and Lead) contamination in carp Cirrhinus cirrhosus. Fish were exposed to 1/10th of LC50 of the respective metals [zinc chloride (2.72 mg/L) and lead acetate (2.53 mg/L)] for 30 days and allowed to recover for another 30 days without any metal exposure. Concentration of metals, different enzymatic and non-enzymatic antioxidant agents and expression levels of heat shock protein (HSP) 70 and 90 were measured in the liver and the kidney of fish. The lipid peroxide levels in fish tissues gradually increased with duration of treatment for both metals. After 15 days of treatment, glutathione (GSH) levels had increased, but decreased as the treatment continued for 30 days and returned to basal levels after a 30-day recovery period. Activities of all the anti-oxidant enzymes, except glutathione peroxidase, in stressed fish were significantly increased compared to those in the control at 15 days and continued till the 30th day of treatment, showing a tendency to return to basal levels after the recovery period. Expression levels of HSP70 and HSP90 gradually increased after zinc and lead treatment, respectively. The expression of HSP was higher in the liver. The results suggest that different heavy metals may have differential effects on the redox state and induction of oxidative stress in carp, in vivo.

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Section: Discussionmentioning

confidence: 99%

Change in redox state and heat shock protein expression in an Indian major carp <i>Cirrhinus cirrhosus</i> exposed to zinc and lead

et al. 2017

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“…In this sense, the plasticity of mitochondrial energy transduction efficiency strongly varies in a phylogenetic manner and in response to environmental factors, such as season, diet and temperature (Heise et al, 2003;Sokolova, 2004;Sommer and Portner, 2004;Brand, 2005;Emel'Yanova et al, 2007;Robert and Bronikowski, 2010). However, according to the above-mentioned theory of limited resources, evolutionary force should have optimized the ATP/O ratio toward better efficiency of the mitochondrial energy transduction system in order to maximize individual fitness.…”

Section: Introductionmentioning

confidence: 99%

Alteration of mitochondrial efficiency affects oxidative balance, development and growth in frog (Rana temporaria) tadpoles

Salin

Luquet

Rey

et al. 2012

Journal of Experimental Biology

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SUMMARYMitochondria are known to play a central role in life history processes, being the main source of reactive oxygen species (ROS), which promote oxidative constraint. Surprisingly, although the main role of the mitochondria is to produce ATP, the plasticity of mitochondrial ATP generation has received little attention in life history studies. Yet, mitochondrial energy transduction represents the physiological link between environmental resources and energy allocated to animal performance. Studying both facets of mitochondrial functioning (ATP and ROS production) would allow better understanding of the proximate mechanisms underlying life history. We have experimentally modulated the mitochondrial capacity to generate ROS and ATP during larval development of Rana temporaria tadpoles, via chronic exposure (34days) to a mitochondrial uncoupler (2,4-dinitrophenol, dNP). The aim was to better understand the impact of mitochondrial uncoupling on both responses in terms of oxidative balance, energy input (oxygen and feeding consumption) and energy output (growth and development of the tadpole). Exposure to 2,4-dNP reduced mitochondrial ROS generation, total antioxidant defences and oxidative damage in treated tadpoles compared with controls. Despite the beneficial effect of dNP on oxidative status, development and growth rates of treated tadpoles were lower than those in the control group. Treatment of tadpoles with 2,4-dNP promoted a mild mitochondrial uncoupling and enhanced metabolic rate. These tadpoles did not increase their food consumption, and thus failed to compensate for the energy loss elicited by the decrease in the efficiency of ATP production. These data suggest that the cost of ATP production, rather than the oxidative balance, is the parameter that constrains growth/development of tadpoles, highlighting the central role of energy transduction in larval performance. Supplementary material available online at

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“…Thus, the increase of copper toxicity at 20 xC relatively to 10 xC may be due to an increased ion turnover at the highest temperature. Also, the raise of temperature in general increases the production of reactive oxygen species (Abele et al, 1998(Abele et al, , 2002Heise et al, 2003) potentially increasing oxidative stress effects and damage. Therefore, the differential effect of temperature on the copper toxicity to E. meridionalis and A. desmarestii suggests that ion turnover and/or oxidative stress targets and defenses are affected by temperature in a different way in the two species.…”

Section: Discussion Bioassays With Single Substances and Temperature mentioning

confidence: 99%

Comparison of three shredders response to acute stress induced by eucalyptus leaf leachates and copper: single and combined exposure at two distinct temperatures

Gama

Guilhermino

Canhoto

2014

Ann. Limnol. - Int. J. Lim.

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-The objectives of this study were to compare the sensitivity of three freshwater macroinvertebrate shredder species (Atyaephyra desmarestii, Echinogammarus meridionalis and Schizopelex festiva) to acute stress induced by eucalyptus leaf extracts and copper, independently and in mixtures, and the ability of temperature to influence the chemicals' toxicity. Laboratory bioassays based on mortality with single substances and mixtures were carried out with the three species at 10 and 20 xC. After 96 h of exposure, S. festiva, A. desmarestii and E. meridionalis were found to have differences of sensitivity to copper, eucalyptus leaf extracts and their mixtures, with S. festiva being the least sensitive species at both 10 and 20 xC. The relative sensitivity of A. desmarestii and E. meridionalis to chemical exposure seems to be chemical and temperature dependent. Overall, these findings suggest that chemical stress may modulate the biodiversity of stream shredders communities due to differential sensitivity of individual species to environmental contaminants, and that temperature may influence the process. Thus, more knowledge on the combined effects of multi-stressors is needed, particularly on temperature and chemicals' interactions and on the molecular mechanisms underlying the responses observed at individual level.

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Production of reactive oxygen species by isolated mitochondria of the Antarctic bivalve Laternula elliptica (King and Broderip) under heat stress

Cited by 144 publications

References 35 publications

Change in redox state and heat shock protein expression in an Indian major carp <i>Cirrhinus cirrhosus</i> exposed to zinc and lead

Change in redox state and heat shock protein expression in an Indian major carp <i>Cirrhinus cirrhosus</i> exposed to zinc and lead

Alteration of mitochondrial efficiency affects oxidative balance, development and growth in frog (Rana temporaria) tadpoles

Comparison of three shredders response to acute stress induced by eucalyptus leaf leachates and copper: single and combined exposure at two distinct temperatures

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