Production of reactive oxygen species by withaferin A causes loss of type collagen expression and COX-2 expression through the PI3K/Akt, p38, and JNK pathways in rabbit articular chondrocytes

Overexpression of MicroRNA-25 by Withaferin A Induces Cyclooxygenase-2 Expression in Rabbit Articular Chondrocytes

“…Our group investigated the properties of WFA on inflammatory effects with treatment at low and high dose. Treatment with low doses (0.1, 0.3, 0.5 mM) inhibited IL-1b-induced COX-2 expression and PGE 2 synthesis but treatment with high doses (1, 3, 5 mM) induced expression of COX-2 in chondrocytes (23). Therefore, our results also induced COX-2 expression by treatment with high doses of WFA in chondrocytes.…”

“…In previous studies, we found that the WFA-induced increase in the expression of COX-2 was strongly related to the inflammation and cartilage degeneration in chondrocytes (23). In addition, we investigated the effects of WFA on inflammation in rabbit articular chondrocytes with specific focus on the regulatory role of miRNA.…”

Effect of Withaferin A on A549 Cellular Proliferation and Apoptosis in Non-small Cell Lung Cancer

“…Therefore, seeking more effective drugs for NSCLC is of great significance in its clinical treatment. Withaferin A is an active ingredient extracted from Withania omnifera (Yu et al, 2013), which possesses the functions of regulating immunity and anti-inflammation, etc.. In recent years, it has also been discovered that Withaferin A has anti-tumor activity and is effective in inhibiting multiple tumors, such as breast cancer, etc.…”

Eucommia ulmoides Oliv. bark aqueous extract inhibits osteoarthritis in a rat model of osteoarthritis

“…Both IL-1β and IL-6 are deemed to display catabolic properties that influence the pathophysiological processes of OA (Rutgers et al, 2010;Yu and Kim, 2013). Previous studies showed that the contents of IL-1β and IL-6 are higher in the serum of OA patients compared with those of the control group (Hussein et al, 2008;Lee et al, 2011), and closely associated with OA patients' pain as well.…”