Production of poly(β-l-malic acid) by Aureobasidium pullulans HA-4D under solid-state fermentation

Xia, Jun; Li, Rongqing; He, Aiyong; Xu, Jiaxing; Liu, Xiaoyan; Li, Xiangqian; Xu, Jiming

doi:10.1016/j.biortech.2017.07.148

Cited by 19 publications

(7 citation statements)

References 39 publications

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“…Powders of A. sinensis were the organic nitrogen and carbohydrate source in the fermentation medium. The solidstate fermentation (XG-2-G/XG-3-G) was composed of 4 g A. sinensis powders, 1 g wheat bran, 6 mL sterile distilled water, and 1 mL bacterium liquid culture (Xia et al, 2017). The liquid fermentation (XG-2-Y/XG-3-Y) was composed of 5 g A. sinensis powders, 95 mL sterile distilled water, and 5 mL bacterium liquid culture.…”

Section: Fermentationmentioning

confidence: 99%

Impact of Bacillus on Phthalides Accumulation in Angelica sinensis (Oliv.) by Stoichiometry and Microbial Diversity Analysis

et al. 2021

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Plant-microorganism interaction in the rhizosphere is thought to play an important role in the formation of soil fertility, transformation and absorption of nutrients, growth and development of medicinal plants, and accumulation of medicinal ingredients. Yet, the role that they play in the phthalides accumulation of Angelica sinensis (Oliv.) Diels remains unclear. In the present study, we report a correlative analysis between rhizosphere microorganisms and phthalides accumulation in A. sinensis from Gansu, China where was the major production areas. Meanwhile, Bacillus was explored the potential functions in the plant growth and phthalide accumulation. Results revealed that the common bacterial species detected in six samples comprised 1150 OTUs which were involved in 368 genera, and predominant taxa include Actinobacteria, Acidobacteria, and Proteobacteria. The average contents of the six phthalides were 4.0329 mg/g. The correlation analysis indicated that 20 high abundance strains showed positive or negative correlations with phthalides accumulation. Flavobacterium, Nitrospira, Gaiella, Bradyrhizobium, Mycobacterium, Bacillus, RB41, Blastococcus, Nocardioides, and Solirubrobacter may be the key strains that affect phthalides accumulation on the genus level. By the plant-bacterial co-culture and fermentation, Bacillus which were isolated from rhizosphere soils can promote the plant growth, biomass accumulation and increased the contents of the butylidenephthalide (36∼415%) while the ligustilide (12∼67%) was decreased. Altogether, there is an interaction between rhizosphere microorganisms and phthalides accumulation in A. sinensis, Bacillus could promote butylidenephthalide accumulation while inhibiting ligustilide accumulation.

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Section: Fermentationmentioning

confidence: 99%

Impact of Bacillus on Phthalides Accumulation in Angelica sinensis (Oliv.) by Stoichiometry and Microbial Diversity Analysis

et al. 2021

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“…The major limitation for commercial use of biopolymers is the high cost of production (Li et al, 2017;Li and Wilkins, 2021). For this reason, several studies have focused on the use of low-cost raw materials from agricultural residues (Sirohi et al, 2020) and fermentation methods that favor competitive production (Shivakumar, 2012;Sallau et al, 2018;Sukruansuwan and Napathorn, 2018;Dalsasso et al, 2019), such as fed batch fermentation processes, which increase the productivity of PHB (Xia et al, 2017;Wilkins, 2020, 2021;Nygaard et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Fed-Batch Fermentation for Production of Polyhydroxybutyrate With a Banana Pulp Juice Substrate From an Agro Industrial By-Product

Arias-Roblero

Mora-Villalobos

Velazquez-Carrillo

2021

Front. Sustain. Food Syst.

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Pollution resulting from the persistence of plastics in the environment has driven the development of substitutes for these materials through fermentation processes using agro-industrial wastes. Polyhydroxybutyrate (PHB) is a rapidly biodegradable material with chemical and mechanical properties comparable to those of some petroleum-derived plastics. PHB accumulates intracellularly as an energy reserve in a wide variety of microorganisms exposed to nutritionally imbalanced media. The objective of this study was to evaluate the use of a banana waste product as a carbon source for PHB production. PHB was extracted by acid methanolysis and detected by gas chromatography-mass spectrometry. Eleven bacterial strains with potential for PHB production were evaluated by in vitro fermentation in a culture broth containing fructose as the carbon source and limited nitrogen. A 22 central composite rotational design was applied to optimize the concentrations of banana juice and ammonium chloride needed to maximize the PHB-producing biomass concentration. The process was then carried out in a 3 L fed-batch fermentation system that included an initial stage of biomass growth. Banana juice was used as the carbon source and fructose pulses were added to maintain the test sugar concentrations of 30, 40, and 50 g/L. The control strain, Cupriavidus necator (ATCC 17699), produced 2.816 g/L of PHB, while productivity of the most promising isolate, C. necator (CR-12), was 0.495 g/L. Maximum biomass production was obtained using 5% banana juice and 2 g/L ammonium chloride. PHB production was not detected in fed-batch fermentations supplemented with 30 or 40 g/L of fructose, while the mean PHB production in fermentations with 50 g/L of fructose was 1.3 g/L.

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“…In accordance, PMA and several PMA-based polymers have been reported in the form of hydrogels [14], tissue engineering scaffolds [15], and drug carriers [16] for biomedical applications. Although PMA is available from natural sources like bacteria, PMA polymers are mostly synthesized via the polycondensation method [17,18,19]. The polycondensation of PMA, based on the dehydration reaction between hydroxyl and carboxyl groups of l -malic acid, is a relatively simple chemistry.…”

Section: Introductionmentioning

confidence: 99%

Polycondensation of a Perylene Bisimide Derivative and L-Malic Acid as Water-Soluble Conjugates for Fluorescent Labeling of Live Mammalian Cells

Chen

Guo

et al. 2018

Polymers

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Based on simple mixing and polymerization of a hydroxyl-containing derivative of perylene bisimide (PBI) and l-malic acid, here, we demonstrate a new type of dye-polymer conjugate, PBI-poly(α,β-malic acid) (PBI–PMA). Benefiting from the excellent water-solubility of weak polyanionic PMA structure and the high fluorescence of PBI, the PBI-PMA conjugates readily dissolve in water, displaying strong pH-dependent fluorescence with the highest intensity at pH 6. Due to the excellent biocompatibility of PMA, those conjugates showed low cytotoxicity on L929 cells. Using L929 and HeLa cells, we also confirmed that the PBI-PMA-labeled cells display intense fluorescence. Overall, the PBI-PMA conjugate demonstrates high potential as a cell labeling agent with its synthesis ease, good solubility in aqueous medium, low cytotoxicity, and high fluorescence.

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Production of poly(β-l-malic acid) by Aureobasidium pullulans HA-4D under solid-state fermentation

Cited by 19 publications

References 39 publications

Impact of Bacillus on Phthalides Accumulation in Angelica sinensis (Oliv.) by Stoichiometry and Microbial Diversity Analysis

Impact of Bacillus on Phthalides Accumulation in Angelica sinensis (Oliv.) by Stoichiometry and Microbial Diversity Analysis

Evaluation of Fed-Batch Fermentation for Production of Polyhydroxybutyrate With a Banana Pulp Juice Substrate From an Agro Industrial By-Product

Polycondensation of a Perylene Bisimide Derivative and L-Malic Acid as Water-Soluble Conjugates for Fluorescent Labeling of Live Mammalian Cells

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