Production of novel vitamin D₃ loaded lipid nanocapsules for milk fortification

Abstract

Lipid nanoparticles are carriers to improve stability, solubility, and efficacy of bioactive compounds. In this paper, novel vitamin D 3 loaded lipid nanocapsules (LNC) were produced by phase inversion method. The produced nanocapsules were characterised by particle size, polydispersity index, zeta potential, encapsulation efficiency, and encapsulation load. LNC showed sizes in the range of 31.43 to 36.66 nm. Optimum LNC formulation was selected for further analysis (such as morphological study, analysis of chemical structure, release study, and sensory evaluation). Transmission electron microscopy revealed that particles had approximately spherical shape. The Fourier transform infrared spectra indicated that no adverse reactions occurred between vitamin D 3 and lipid nanocapsules. About 9.6% of vitamin released in gastric simulated solution (pH: 1.2), which indicated that LNC can protect vitamin against acidic conditions. Sensory evaluation revealed the potential application of produced vitamin D 3 loaded LNC for development of fortified milk.

Spanish olive leaf extract‐loaded nanostructured lipid carriers: Production and physicochemical characterization by Zetasizer, FT‐IR, DTA/TGA, FE‐SEM and XRD

“…This could be probably due to more solubility of the encapsulation material in the liquid part of the lipid. Results in this study were consistent with results of other researchers (Kiani, Fathi, & Ghasemi, ; Soleimanian et al, ; Yuan, Wang, Ye, Tao, & Zhang, ).…”

“…Results in this study were consistent with results of other researchers (Kiani, Fathi, & Ghasemi, 2016;Soleimanian et al, 2018;Yuan, Wang, Ye, Tao, & Zhang, 2015).…”

Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol

“…Absorbance bands from C=O stretching at 1635 and 1440 cm −1 , C-O group at 1054 cm −1 and CH 2 group at 895 cm −1 are assigned. Other bands are related to several C-H bendings in the cholecalciferol structure [28] .…”

β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

“…The liquid reservoirs of oil inside the solid core lead to a high tendency of the drug to remain entrapped for a longer time inside the network lattice [45]. Another reason could be the rigid solid external shell of NLCs which may be resistant to digestion and act as a barrier for the diffusion of the encapsulated drug [46]. Both NLC formulations showed significant improvement in their drug release profiles compared with the plain drug suspension, due to dissolution enhancement [47].…”