Production of no-carrier-added 11C-carbon disulfide and 11C-hydrogen cyanide by microwave discharge

Chemie der Positronenemissionstomographie: Aktuelle Fortschritte bei 11C‐, 18F‐, 13N‐ und 15O‐Markierungsreaktionen

“…Mehrere 11 C‐markierte Tracer, unter anderem [ 11 C]Vabicaserin und [ 11 C]WAY‐163909, wurden effizient durch die Pictet‐Spengler‐Reaktion unter Verwendung von [ 11 C]HCHO hergestellt . [ 11 C]CS 2 wurde zuerst mit geringer RCY aus [ 11 C]CO 2 und H 2 S erzeugt . 2012 entwickelten dann Miller et al.…”

A Systematic Investigation of [11C]-HCN Production

“…A microwave discharge conversion of ''CO2, H2, N2 mixtures to [i^C]-HCN with yields of ca. 40%, has been described by Niisawa et al [16]; this system also produces [ Since the recovery losses in the direct in target formation of [^'C]-CH4 can be reduced to less than 25%, the direct method has advantages over the ^C]-CO2 reduction pathway, by allowing the omission of a catalytic oven and two controlled gas feeding systems for hydrogen and for ammonia. This simplifies the whole production system considerably.…”

[11C]Carbon Disulfide: A Versatile Reagent for PET Radiolabelling

“…= 46 8C) and is considered to be more reactive owing to the weaker C=S double bond. Considering the now widespread use of small and reactive 11 C molecules, such as CO, CO 2 , HCN, COCl 2 , CH 3 OTf and CH 3 I, in the PET field it is surprising that there has only been one previous report of 11 CS 2 , obtained in low radiochemical yields, [9] even though it has enormous potential to form a wide range of organic molecules that may hold promise for potential applications in PET imaging. Herein, we report a new method for the rapid and high yielding synthesis of 11 CS 2 and demonstrate its reactivity for the first time as an effective route to 11 C-labelled organosulfur compounds.…”