Production of nitrogen dioxide during nitric oxide therapy using the Servo Ventilator 300 during volume‐controlled ventilation

Lindberg, Lars; Rydgren, G

doi:10.1034/j.1399-6576.1999.430308.x

Cited by 6 publications

(1 citation statement)

References 17 publications

(23 reference statements)

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“…1 Factors influencing the generation of NO 2 include F IO 2 , dose of INO, and dwell time for INO and oxygen. 12 NO 2 accumulation is more likely to form when using high F IO 2 in combination with high INO concentrations. It is unclear whether the complicated physical gas flow pathways of neonatal noninvasive support or the upper airway fosters an environment wherein toxic levels of NO 2 can accumulate and be inhaled into the lungs.…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide Delivery by Neonatal Noninvasive Respiratory Support Devices

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Nitric Oxide Delivery by Neonatal Noninvasive Respiratory Support Devices

et al. 2014

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NO Signaling in the Cardiovascular System and Exercise

Fernandes

Gomes-Gatto

Pereira

et al. 2017

Advances in Experimental Medicine and Biology

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Nitric oxide (NO) is a small molecule implicated in multiple signal transduction pathways thus contributing to the regulation of many cellular functions. The identification of NO synthase (NOS) isoforms and the subsequent characterization of the mechanisms of cell activation of the enzymes permitted the partial understanding of both the physiological and pathological processes. NO bioavailability plays an important role in the pathophysiology of cardiovascular disease and its reduction in endothelial cells is strictly associated to endothelial dysfunction which, in turn, correlates with cardiovascular mortality. Indeed, endothelial NO synthase (eNOS) has a key role in limiting cardiac dysfunction and remodeling in heart diseases, in part by decreasing myocyte hypertrophy. Conversely, exercise training is recommended to prevent and treat cardiovascular diseases-associated disorders at least by enhanced NO synthase activity and expression, and increased production of antioxidants, which prevents premature breakdown of NO. Exercise training may cause an improvement in endothelial function for both experimental animals and humans; Studies in both healthy subjects and patients with impaired NO-related vasorelaxation remarked exercise training ability to improve vascular structure and function and endothelial homeostasis. This chapter will briefly consider the importance of NO signaling in the maintenance of cardiovascular physiology, and discuss recent insights into the effect of exercise training on the signaling pathways that modulate NO synthesis and degradation in health and cardiovascular disease. In addition, we will highlight the molecular mechanisms via which microRNAs (miRs) target NO signaling in the cardiovascular system, and NO as a candidate molecule for development of new therapies.

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