Production of Nanoemulsions from Palm-Based Tocotrienol Rich Fraction by Microfluidization

Goh, Pik Seah; Ng, Mei Han; Choo, Yuen May; Amru, N. B.; Chuah, Cheng Hock

doi:10.3390/molecules201119666

Cited by 38 publications

(13 citation statements)

References 29 publications

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“…Surfactants were selected based on hydrophilic lipophilic balance of the two phases, while method of preparation was chosen among high energy processes that are able to produce stable nanoemulsions. High pressure homogenization ( Alayoubi et al, 2013 ), microfluidization ( Goh et al, 2015 ; Hasan et al, 2018 ), and PIT emulsification ( Pham et al, 2016 ) were studied, each having distinctive advantages. For example, narrow size distribution was observed in nanoemulsions prepared using microfluidization with increasing pressure and number of cycles ( Goh et al, 2015 ).…”

Section: Application Of Nanoformulations For Tocotrienolsmentioning

confidence: 99%

“…High pressure homogenization ( Alayoubi et al, 2013 ), microfluidization ( Goh et al, 2015 ; Hasan et al, 2018 ), and PIT emulsification ( Pham et al, 2016 ) were studied, each having distinctive advantages. For example, narrow size distribution was observed in nanoemulsions prepared using microfluidization with increasing pressure and number of cycles ( Goh et al, 2015 ). Hybrid of more than 1 method (e.g., PIT and homogenization) was shown to produce nanoemulsion that remained stable after 2 months’ storage ( Pham et al, 2016 ).…”

Section: Application Of Nanoformulations For Tocotrienolsmentioning

confidence: 99%

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Challenges and Opportunities of Nanotechnology as Delivery Platform for Tocotrienols in Cancer Therapy

Maniam

Zulkefeli

et al. 2018

Front. Pharmacol.

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Plant-derived phytonutrients have emerged as health enhancers. Tocotrienols from the vitamin E family gained high attention in recent years due to their multi-targeted biological properties, including lipid-lowering, neuroprotection, anti-inflammatory, antioxidant, and anticancer effects. Despite well-defined mechanism of action as an anti-cancer agent, their clinical use is hampered by poor pharmacokinetic profile and low oral bioavailability. Delivery systems based on nanotechnology were proven to be advantageous in elevating the delivery of tocotrienols to tumor sites for enhanced efficacy. To date, preclinical development of nanocarriers for tocotrienols include niosomes, lipid nanoemulsions, nanostructured lipid carriers (NLCs) and polymeric nanoparticles. Active targeting was explored via the use of transferrin as targeting ligand in niosomes. In vitro, nanocarriers were shown to enhance the anti-proliferative efficacy and cellular uptake of tocotrienols in cancer cells. In vivo, improved bioavailability of tocotrienols were reported with NLCs while marked tumor regression was observed with transferrin-targeted niosomes. In this review, the advantages and limitations of each nanocarriers were critically analyzed. Furthermore, a number of key challenges were identified including scale-up production, biological barriers, and toxicity profiles. To overcome these challenges, three research opportunities were highlighted based on rapid advancements in the field of nanomedicine. This review aims to provide a wholesome perspective for tocotrienol nanoformulations in cancer therapy directed toward effective clinical translation.

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Section: Application Of Nanoformulations For Tocotrienolsmentioning

confidence: 99%

Section: Application Of Nanoformulations For Tocotrienolsmentioning

confidence: 99%

Challenges and Opportunities of Nanotechnology as Delivery Platform for Tocotrienols in Cancer Therapy

Maniam

Zulkefeli

et al. 2018

Front. Pharmacol.

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“…Plant bioactive compound-based nanodelivery systems development using microfluidization is an emerging technique to enhance the stability and bioavailability of the incorporated plant bioactive compounds. 26,33 Development of stable nanodelivery systems using plant bioactive compounds has been a research area of emerging delivery systems in the medical field, thereby facilitating oral delivery without much loss in activity. [33][34][35] Microfluidization mechanism is very essential to understand the development of stable nanodelivery systems, thereby enhancing the production of those systems with broader applications through the interdisciplinary approach of nutraceuticals and medicine.…”

Section: Microfluidizationmentioning

confidence: 99%

“…26,33 Development of stable nanodelivery systems using plant bioactive compounds has been a research area of emerging delivery systems in the medical field, thereby facilitating oral delivery without much loss in activity. [33][34][35] Microfluidization mechanism is very essential to understand the development of stable nanodelivery systems, thereby enhancing the production of those systems with broader applications through the interdisciplinary approach of nutraceuticals and medicine. 36,37 The microfluidization process is a type of high energy process which works on the dynamics of the specially designed microchannels.…”

Section: Microfluidizationmentioning

confidence: 99%

Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments

Ganesan

Karthivashan

Park

et al. 2018

IJN

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Plant bioactive compounds are known for their extensive health benefits and therefore have been used for generations in traditional and modern medicine to improve the health of humans. Processing and storage instabilities of the plant bioactive compounds, however, limit their bioavailability and bioaccessibility and thus lead researchers in search of novel encapsulation systems with enhanced stability, bioavailability, and bioaccessibility of encapsulated plant bioactive compounds. Recently many varieties of encapsulation methods have been used; among them, microfluidization has emerged as a novel method used for the development of delivery systems including solid lipid nanocarriers, nanoemulsions, liposomes, and so on with enhanced stability and bioavailability of encapsulated plant bioactive compounds. Therefore, the nanodelivery systems developed using microfluidization techniques have received much attention from the medical industry for their ability to facilitate controlled delivery with enhanced health benefits in the treatment of various chronic diseases. Many researchers have focused on plant bioactive compound-based delivery systems using microfluidization to enhance the bioavailability and bioaccessibility of encapsulated bioactive compounds in the treatment of various chronic diseases. This review focuses on various nanodelivery systems developed using microfluidization techniques and applications in various chronic disease treatments.

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“…Considering the importance of this molecule, in this study, we analysed the preparation and characterization of squalene oil-inwater emulsions stabilized by different non-ionic emulsifiers [5, 11, 14 -16]. As non-ionic emulsifiers we used polyoxyethylene (20) sorbitan monooleate (Tween 60) and sorbitan monooleate (Span 80) due to their low toxicity, biocompatibility and applicability in food, cosmetics, and pharmaceutical [11,14,17].…”

Section: Abstract: Emulsion Physical Stability Squalene Viscositymentioning

confidence: 99%

Rheological Properties and Stability of Squalene Emulsion Prepared with Non-Ionic Emulsifier

Anghelache¹,

Kim²,

Cuciureanu³

et al. 2017

Rev. Chim.

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Squalene is natural occurring polyprenyl compound with a linear triterpene chemical structure commonly found in animal and vegetal sources such as skin lipids from human body, liver of certain species of fish, especially sharks, crude vegetable oils (e.g olive, amaranth, palm oil etc.). Recently there has been an increasing interest in studying polymers that can be used as promising emulsions for drug delivery and vaccine applications. Recent studies proved that squalene has several beneficial and unique properties such as natural antioxidant, ensure skin hydration, biocompatibility. This can be used as such or for preparing stable and non-toxic emulsions. Herein we present the preparation and characterization of squalene oil-inwater emulsions stabilized by different non-ionic emulsifiers. Emulsion stability is a primary concern, therefore physical stability of squalene emulsions was also investigated. The major aim of the study was to find the optimal preparation conditions and assessing emulsion stability correlated with their viscosity and composition. In order to establish the connection between their physical stability and viscosity were performed rheological studies.

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Production of Nanoemulsions from Palm-Based Tocotrienol Rich Fraction by Microfluidization

Cited by 38 publications

References 29 publications

Challenges and Opportunities of Nanotechnology as Delivery Platform for Tocotrienols in Cancer Therapy

Challenges and Opportunities of Nanotechnology as Delivery Platform for Tocotrienols in Cancer Therapy

Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments

Rheological Properties and Stability of Squalene Emulsion Prepared with Non-Ionic Emulsifier

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