Production of monodisperse epigallocatechin gallate (EGCG) microparticles by spray drying for high antioxidant activity retention

Fu, Nan; Zhou, Zihao; Jones, Tyson Byrne; Tan, Timothy Thatt Yang; Wu, Winston Duo; Lin, Sean Xuqi; Chen, Xiao; Chan, Peggy

doi:10.1016/j.ijpharm.2011.04.056

Cited by 71 publications

(30 citation statements)

References 46 publications

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“…Using the drying temperatures ranging between 70 °C and 130 °C showed a little effect on antioxidant activity of EGCG since NMR spectrum studies indicated that EGCG did not undergo chemical structural change during encapsulation process. These results confi rmed that low-temperature drying method is favorable for the maintenance of optimized chemopreventive activity of EGCG [ 120 ].…”

Section: Microparticlessupporting

confidence: 60%

Nano-encapsulation of a Natural Polyphenol, Green Tea Catechins: Way to Preserve Its Antioxidative Potential

Dang

Gupta

Bansal

et al. 2014

Free Radicals in Human Health and Disease

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Emanating from extensive research carried out all over the globe, green tea has been acknowledged for plethora of pharmacological activities like anti-infl ammatory, antimicrobial, antitumor, antiaging, and many more. This wide array of health effects have been attributed to green tea catechins (GTCs). These GTCs correspond to the class of antioxidants which scavenge the precarious free radicals in the body and, thus, prevent the progression of various diseases. However, poor bioavailability, short halflife, stability issues, and short shelf life hamper its use as a therapeutic agent. To address these limitations, various encapsulation techniques have been explored by the scientists. The encapsulation techniques employed for green tea and its catechins range from microparticles, microcapsules, nanoparticles, and lipid nanocapsules to self assembly approaches like liposomes, micelles, and microemulsions. Encapsulation not only helps in enhancing the aqueous solubility and stability of the GTCs but also provides for controlled and sustained release thus protecting their biological/ pharmacological activity in systemic circulation. At the same time, sustained release is likely to enhance bioavailability and thus can reduce the likelihood of repeated use. The aim of this chapter is to discuss the role of green tea as an antioxidant and various nano-encapsulation strategies to enhance the effi cacy of related products. It also provides an insight into some of the commercial and patented green tea-based products.

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Section: Microparticlessupporting

confidence: 60%

Nano-encapsulation of a Natural Polyphenol, Green Tea Catechins: Way to Preserve Its Antioxidative Potential

Dang

Gupta

Bansal

et al. 2014

Free Radicals in Human Health and Disease

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show abstract

“…Fu et al (2011) determined that the drying temperature (in the range of 70-130°C) of EGCG nanoparticles produced by spray drying has little effect on the particle morphology, indicating that the used lower temperature in the present study is justified. The extensively dented surface of oligofructose (Fig.…”

Section: Sem Microscopy and Ftirmentioning

confidence: 79%

“…1d) encapsulated microparticles has also been observed in previous studies, such as in gum arabic-maltodextrin microparticles encapsulating EGCG (Peres et al 2011), nopal mucilage (Opuntia ficus indica) microparticles encapsulating gallic acid (Medina-Torres et al 2013) and ß-carotene using modified tapioca starch and maltodextrin as encapsulating agents (Loksuwan 2007). In case of using inulin, starch or hydrocolloid gums (acacia, guar, LBG, xanthan), corrugated surface of the particles can be especially observed, which may be attributed to uneven drying and shrinkage, as previously observed by Fu et al (2011). According to the same authors, the shrinkage of particles occurs due to the slow diffusion rate of encapsulated compounds (in our case green tea polyphenols and caffeine) inside the particle.…”

Section: Sem Microscopy and Ftirmentioning

confidence: 90%

Efficiency Assessment of Natural Biopolymers as Encapsulants of Green Tea (Camellia sinensis L.) Bioactive Compounds by Spray Drying

Belščak‐Cvitanović

Lević

Kalušević

et al. 2015

Food Bioprocess Technol

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In this study a bottom-up approach of designing functional ingredients from green tea extract is proposed by a systematic investigation of 12 different natural biopolymers and their efficiency as carrier materials of green tea bioactive compounds by spray drying at low temperature (130°C). Screening of carriers revealed that inulin and whey proteins provide the highest product yields (67.04 and 65.18 %, respectively) and, accompanied with pectin, also the highest total polyphenols (67.5-82.2 %) and flavan-3-ols (93.7-75.9 %) loading capacity. Up to 162 mg/g of (−)−epigallocatechin gallate (EGCG) was achieved, while low-caffeine contents (<5 mg/g) indicated the potential of obtaining lowcaffeine functional ingredients. Employing alginate, carageenan and gums (acacia gum and xanthan) enabled the best colour preservation and highest chlorophyll content. Reconstituted green tea microencapsulates comprising modified starch, inulin or carageenan exhibited the lowest bitterness and astringency and the highest green tea flavour intensity as the most favourable sensory properties. An artificial neural network (ANN) designed based on the experimentally obtained results revealed hydrocolloid gums as the best encapsulants for achieving good physical properties, high EGCG contents and prolonged dissolution/release profiles while pectin, inulin and modified starch as the optimal ones in terms of the product yields, loading capacities and sensory properties. This indicates that a formulation comprising a combination of all of those biopolymers would provide potentially functional ingredients with encapsulated green tea phytochemicals, retained colour and improved sensory properties.

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“…The MFJSD equipped with MFAN has been shown to be very versatile in the generation of powders of up to 20 g/h (Fig. 5), with the applications to date including, but not limited to, functional foods (Fu et al, 2011;Fang, Rogers, Selomulya, & Chen, 2012), photoluminescent composites (Wu et al, 2011a), ultra high temperature ceramics (Zhong et al, 2012), magnetic materials Amelia, Wu, Chen, & Selomulya, 2012), microencapsulates (Liu, Selomulya, & Chen, 2013a;Liu et al, 2013b;Liu, Wu, Selomulya, & Chen, 2011a, 2011b, 2013cWu, Liu, Selomulya, & Chen, 2011c), and mesoporous microparticles (Waldron et al, 2014a,b;Wu et al, 2013). The next section will provide a brief overview of uniform microparticles generated via the microfluidic jet spray drying technique, and their potential applications for encapsulation and controlled release.…”

Section: Microfluidic Aerosol Nozzle (Mfan)mentioning

confidence: 99%

On the spray drying of uniform functional microparticles

2015

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Production of monodisperse epigallocatechin gallate (EGCG) microparticles by spray drying for high antioxidant activity retention

Cited by 71 publications

References 46 publications

Nano-encapsulation of a Natural Polyphenol, Green Tea Catechins: Way to Preserve Its Antioxidative Potential

Nano-encapsulation of a Natural Polyphenol, Green Tea Catechins: Way to Preserve Its Antioxidative Potential

Efficiency Assessment of Natural Biopolymers as Encapsulants of Green Tea (Camellia sinensis L.) Bioactive Compounds by Spray Drying

On the spray drying of uniform functional microparticles

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