Production of monoclonal antibodies against human erythropoietin and their use in the purification of human urinary erythropoietin

A case of erythrocytosis caused by a hepatocellular carcinoma (HCC) that produced erythropoietin (Epo) is described. A 64-year-old man, with a huge HCC tumor in the right lobe of the liver, showed a high concentration of hemoglobin and increased levels of serum Epo, alpha-fetoprotein (AFP), and protein induced by vitamin K absence II (PIVKA-II). Right lobectomy of the liver was performed. Histological findings of the specimen showed a moderately differentiated HCC. The existence of Epo was confirmed immunohistochemically only in the tumor tissue and not in the normal liver tissue. Erythrocytosis disappeared and the serum levels of Epo, AFP, and PIVKA-II returned to the normal range after the operation. Within 2 months after the operation, recurrent tumors appeared in the remnant liver, and the patient died 13 months after the operation.

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Erythrocytosis caused by an erythropoietin-producing hepatocellular carcinoma

Matsuyama

Horii

Higaki

et al. 2000

J. Surg. Oncol.

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Chromatographic purification of recombinant human erythropoietin

2019

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Production and characterization of monoclonal antibodies against rat platelet GPIIb/IIIa

Miyazaki

Tamura

Sudo

et al. 1990

Thrombosis Research

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Production of monoclonal antibodies against human erythropoietin and their use in the purification of human urinary erythropoietin

Cited by 10 publications

References 12 publications

Erythrocytosis caused by an erythropoietin-producing hepatocellular carcinoma

Erythrocytosis caused by an erythropoietin-producing hepatocellular carcinoma

Chromatographic purification of recombinant human erythropoietin

Production and characterization of monoclonal antibodies against rat platelet GPIIb/IIIa

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