Production of medical radioisotopes with linear accelerators

Starovoitova, Valeriia N.; Tchelidze, L.; Wells, Douglas P.

doi:10.1016/j.apradiso.2013.11.122

Cited by 117 publications

(44 citation statements)

References 19 publications

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“…Accelerators are more desirable than nuclear reactors in light of the relative low volume of radioactive waste, the considerably lower ecological impacts, and overall lower operational costs. Electron linear accelerators can produce large quantities of beneficial medical radioisotopes, including 67 Cu and 47 Sc [2,3].…”

Section: Introductionmentioning

confidence: 99%

Accelerator-based photoproduction of promising beta-emitters 67Cu and 47Sc

Starovoitova

Cole

Grimm

2015

J Radioanal Nucl Chem

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In this paper we discuss our experimental work in photoproducing two medically-useful radioisotopes ( 68 Zn(c,p) 67 Cu and 48 Ca(c,n) 47 Ca ? 47 Sc) using an electron linear accelerator. We further address the issues of production and separation of medical isotopes arising from photoneutron (c,n) and photoproton (c,p) reactions. While (c,n) reactions typically result in greater yields, separating product nuclides from the target is challenging since the chemical properties of both nuclides are identical. Although the yields of (c,p) reactions are typically lower than for (c,n), these proton-rich isotopes have the advantage that target and product nuclides belong to different chemical species allowing for more straightforward chemical separation. We conclude the paper by touching upon the dire necessity of experimentally revisiting a broad swath of photonuclear reactions in the 10-to 50-MeV regime. The very paucity of empirical cross-sectional data makes it altogether impossible to realistically predict accelerator-based photoproduction of many promising radiopharmaceuticals.

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Section: Introductionmentioning

confidence: 99%

Accelerator-based photoproduction of promising beta-emitters 67Cu and 47Sc

Starovoitova

Cole

Grimm

2015

J Radioanal Nucl Chem

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“…As regards the 70 Zn(d,na) 67 Cu and 64 Ni(a,p) 67 Cu reactions, so far only cross sections have been measured [48,49] and the expected respective yield is low. In recent years there has been an increasing interest in the utilization of electron linear accelerators for medical radionuclide production and the reaction 68 Zn(c,p) 67 Cu has been investigated in some detail [50]. The yield of 67 Cu for a nat Zn target amounting to 1 MBq/(g kW h) is, however, rather low.…”

Section: Cumentioning

confidence: 99%

Nuclear data for medical radionuclides

Qaim

2015

J Radioanal Nucl Chem

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Radionuclides are used in medicine both for diagnosis and therapy. The radioactive decay data play a key role in the choice of a radionuclide for a certain application. The nuclear reaction data, on the other hand, allow to optimise the production route of a chosen radionuclide. The status of nuclear data of the commonly used diagnostic and therapeutic radionuclides is reviewed and the recent efforts to standardise those data are described. The expected specific activity of the cyclotron produced 99m Tc is briefly discussed. The present efforts are devoted to development of non-standard positron emitters (e.g. 64 Cu, 86 Y, etc.) and low-range highly-ionising therapeutic radionuclides (e.g. 67 Cu, 225 Ac, etc.). The need of intermediate-energy multiple-particle accelerating cyclotrons is pointed out.

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“…24,25] but it shows some discrepancy with the value integrated from the excitation function. In the case of the (γ ,p) reaction, only the integral yield has been measured [26]. Among the two charged-particle induced reactions, cross section data of the low energy 70 Zn(p,α) 67 Cu reaction appear to be reliable but the yield is low and the target material is very expensive.…”

Section: Novel Therapeutic Radionuclidesmentioning

confidence: 99%

“…The produc-tion yield for the 68 Zn(γ ,p) 67 Cu reaction is taken from Ref. [26] and that for the 67 Zn(n,p) 67 Cu reaction from Ref. [25], in both cases using a nat Zn target.…”

Section: Novel Therapeutic Radionuclidesmentioning

confidence: 99%

Nuclear data for medical applications: An overview of present status and future needs

Syed

2017

EPJ Web Conf.

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Abstract.A brief overview of nuclear data required for medical applications is given. The major emphasis is on radionuclides for internal applications, both for diagnosis and therapy. The status of the presently available data is discussed and some of the emerging needs are outlined. Most of the needs are associated with the development of non-standard positron emitters and novel therapeutic radionuclides. Some new developments in application of radionuclides, e.g. theranostic approach, multimode imaging, radionanoparticles, etc. are described and the related nuclear data needs are discussed. The possible use of newer irradiation technologies for medical radionuclide production, e.g. intermediate energy charged-particle accelerators, high-power electron accelerators for photon production, and spallation neutron sources, will place heavy demands on nuclear data.

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Production of medical radioisotopes with linear accelerators

Cited by 117 publications

References 19 publications

Accelerator-based photoproduction of promising beta-emitters 67Cu and 47Sc

Accelerator-based photoproduction of promising beta-emitters 67Cu and 47Sc

Nuclear data for medical radionuclides

Nuclear data for medical applications: An overview of present status and future needs

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