Production of medical isotopes from a thorium target irradiated by light charged particles up to 70 MeV

Duchemin, Charlotte; Guertin, Arnaud; Haddad, Férid; Michel, Nathalie; Métivier, Vincent

doi:10.1088/0031-9155/60/3/931

Cited by 29 publications

(25 citation statements)

References 33 publications

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“…ondary radioisotope production The interaction of 70 Zn at 15 MeV/nucleon with the proton target produces about 1.6 neutrons per reaction, as calculated with the code TALYS (Koning (2012); Duchemin (2015)). Along with the heavy reaction products, these neutrons are also kinematically focused in the forward direction and can be exploited for further radioisotope production by simply letting them interact with a secondary target, e.g., a 68 Zn or nat Zn target for additional production of 67 Cu.…”

Section: Use Of the Neutrons From The Primary Reaction For Sec-mentioning

confidence: 99%

A novel approach to medical radioisotope production using inverse kinematics: A successful production test of the theranostic radionuclide 67Cu

Souliotis

Rodrigues

Wang

et al. 2019

Applied Radiation and Isotopes

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A novel method for the production of important medical radioisotopes has been developed. The approach is based on performing the nuclear reaction in inverse kinematics, namely sending a heavy-ion beam of appropriate energy on a light target (e.g. H, d, He) and collecting the isotope of interest. In this work, as a proof-of-concept, we studied the production of the theranostic radionuclide 67 Cu (T 1/2 =62 h) via the reaction of a 70 Zn beam at 15 MeV/nucleon with a hydrogen gas target. The 67 Cu radionuclide, alongside other coproduced isotopes, was collected after the gas target on an Al catcher foil and their radioactivity was measured by offline γ-ray analysis. After 36 h from the end of the irradiation, apart from the product of interest 67 Cu, the main radioimpurity coming from the 70 Zn+p reaction was 69m Zn (T 1/2 =13.8 h) that can be reduced by further radio-cooling. Moreover, along with the radionuclide of interest produced in inverse kinematics, the production of additional radioisotopes is possible by making use of the forward-focused neutrons from the reaction and letting them interact with a secondary target. A preliminary successful test of this concept was realized in the present study. The main requirement to obtain activities appropriate for preclinical studies is the development of high-intensity heavy-ion primary beams.

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Section: Use Of the Neutrons From The Primary Reaction For Sec-mentioning

confidence: 99%

A novel approach to medical radioisotope production using inverse kinematics: A successful production test of the theranostic radionuclide 67Cu

Souliotis

Rodrigues

Wang

et al. 2019

Applied Radiation and Isotopes

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“…The production cross section data are obtained using the stacked-foil method [2,7], which consists of the irradiation of a set of thin foils, grouped as patterns. Each pattern contains a target to produce the isotopes of interest.…”

Section: Experimental Set-upmentioning

confidence: 99%

“…In this frame, production cross sections and thick target yields were measured for alpha emitters, such as the U-230/Th-226, Th-227/Ra-223 and Ac-225/ Bi-213 generators [2]; for photon, Tc-99m [2], and positon, Sc-44g [3], emitters for diagnosis; for electron emitters Re-186g [4], Tb-155 [5] and Sn-117m [6] for therapeutic applications. From the irradiated materials, new experimental production cross section data of interest for medical applications and monitor reactions have been extracted which allow to expand our knowledge on these excitation functions, to confirm the existing trends and to give additional values on a wider energy range.…”

Section: Introductionmentioning

confidence: 99%

How nuclear data collected for medical radionuclides production could constrain nuclear codes

et al. 2017

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Abstract. The aim of this article is to give the status of nuclear data collected in the framework of the production of innovative radionuclides for therapy and diagnosis applications in collaboration with the GIP ARRONAX, which possesses a multi-particle high energy cyclotron, and to show constrains that can be put on nuclear codes. In order to assess the cross section of a given production route, experiments have been carried out using the stacked-foil technique and gamma-spectroscopy for a set of radionuclides of medical interest: photon (Tc-99m) and positon (Sc-44g) emitters for diagnosis, electron (Re-186g, Tb-155, Sn-117m) and alpha particle (Th-226, Ra-233, Bi-213) emitters for therapeutic applications. A systematic comparison has been performed between the results from the TALYS code (version 1.6) and the large set of data collected using different projectiles (proton, deuteron and alpha particle) from few MeV up to 70 MeV and covering a wide range of target masses. A better overall agreement with our experimental data has been obtained with a combination of models already included in the TALYS code differing from the default one.

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“…The cross section data are obtained using the stacked-foils method [5,6], which consists of the irradiation of a set of thin foils, grouped as patterns. Each pattern contains a target to produce the isotopes of interest.…”

Section: Experimental Set-upmentioning

confidence: 99%

“…This accelerator has been used for our study on the Th-232(p,x) and Th-232(d,x) reactions. The main motivation was to study the production cross section of Pa-230 that decays to Th-226 [5] via U-230. After the irradiations, the activity values were determined by gamma spectrometry, and the associated spectra give information on the production of several fission products inside the thorium-232 target.…”

Section: Introductionmentioning

confidence: 99%

Thorium-232 fission induced by light charged particles up to 70 MeV

et al. 2017

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Abstract. Studies have been devoted to the production of alpha emitters for medical application in collaboration with the GIP ARRONAX that possesses a high energy and high intensity multi-particle cyclotron. The productions of Ra-223, Ac-225 and U-230 have been investigated from the Th-232(p,x) and Th-232(d,x) reactions using the stacked-foils method and gamma spectrometry measurements. These reactions have led to the production of several fission products, including some with a medical interest like Mo-99, Cd-115g and I-131. This article presents cross section data of fission products obtained from these undedicated experiments. These data have been also compared with the TALYS code results.

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Production of medical isotopes from a thorium target irradiated by light charged particles up to 70 MeV

Cited by 29 publications

References 33 publications

A novel approach to medical radioisotope production using inverse kinematics: A successful production test of the theranostic radionuclide 67Cu

A novel approach to medical radioisotope production using inverse kinematics: A successful production test of the theranostic radionuclide 67Cu

How nuclear data collected for medical radionuclides production could constrain nuclear codes

Thorium-232 fission induced by light charged particles up to 70 MeV

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