Production of Macrophage Inhibitory Factor by Patients With Leprosy

Katz, Stephen I.; DeBetz, Barbara H.; Zaias, Nardo

doi:10.1001/archderm.1971.04000160008002

Cited by 19 publications

(2 citation statements)

References 11 publications

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“…Suppressor cells that cause depressed delayed-dermal responses have been described in experimental leprosy (39) and histoplasmosis (40). Interestingly, comparison of groups of patients with tuberculoid or lepromatous leprosy revealed that the peripheral blood lymphocytes of the latter have a reduced capacity to produce MIF (41) or maerophage aggregation factor (42) in response to lepromin. One may postulate from such studies that Ts cells are blocking lymphokine-mediated granuloma formation, thereby causing the dissemination of organisms seen in lepromatous leprosy.…”

Section: Discussionmentioning

confidence: 99%

Regulation of granulomatous inflammation in murine schistosomiasis. In vitro characterization of T lymphocyte subsets involved in the production and suppression of migration inhibition factor.

Chensue

Boros

David³

1980

The Journal of Experimental Medicine

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Host granulomatous inflammation in murine schistosomiasis mansoni is a T cell-mediated immune response, which, at the chronic stage of the disease, undergoes T suppressor lymphocyte-dependent modulation. In the present study this phenomenon was further analyzed in vitro. Spleen cells of mice undergoing modulation (20 wk of infection) when mixed with spleen cells of animals exhibiting vigorous granulomatous responses (8 wk of infection) abrogated in vitro migration inhibition factor (MIF) production by the latter. Characterization of the delayed-type hypersensitivity T lymphocytes involved in lymphokine production showed that they belonged to the Lyt-1+ subset and did not express I region-encoded antigens. In contrast, T lymphocytes involved in the suppression of MIF activity belonged to the Lyt-2+ subpopulation of cells, which expressed I-J- and I-C-subregion determinants. These results suggest that the modulation of the granulomatous hypersensitivity response in mice is the result of T-T cell interaction with subsequent regulation of inflammatory lymphokine production.

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Section: Discussionmentioning

confidence: 99%

Regulation of granulomatous inflammation in murine schistosomiasis. In vitro characterization of T lymphocyte subsets involved in the production and suppression of migration inhibition factor.

Chensue

Boros

David³

1980

The Journal of Experimental Medicine

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“…Bullock et al (8) reported that increased DNA synthesis in lymphocytes stimulated by mycobacterial antigens was not observed in LL patients, although the DNA synthesis was much increased in some of the TT patients; also, while it was hardly observed among normal persons, there was an excep-tional increase among persons who had lived in regions infested with leprosy. Katz et al (9) reported that the production of a macrophage inhibitory factor in lymphocytes stimulated by lepromin was less in LL patients than in TT patients.…”

Section: Mitsuda Reactionmentioning

confidence: 99%

Lymphocyte Transformation Using Mitsuda Antigen (Lepromin)

Yamada

Fujimoto

1975

The Journal of Dermatology

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A lymphocyte transformation test was performed adding Mitsuda antigen (lepromin) to the lymphocyte culture from the peripheral blood of 4 leprosy patients (2 borderline lepromatous and 2 lepromatous ones) and 6 control persons (1 Kimura disease patient, 1 kerion celsi patient, 2 latent syphilis patients and 2 normal controls—doctors). All 4 leprosy patients showed negative results, while 1 to 3% blast cells were observed in 5 of the control cases; the one case with Kimura disease showed a negative result. Only 12 to 21% blast cells stimulated by PHA were observed in the lepromatous patients.

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Immunologic Responses in Patients With Lepromatous Leprosy

Rea¹

1976

Arch Dermatol

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Production of Macrophage Inhibitory Factor by Patients With Leprosy

Cited by 19 publications

References 11 publications

Regulation of granulomatous inflammation in murine schistosomiasis. In vitro characterization of T lymphocyte subsets involved in the production and suppression of migration inhibition factor.

Regulation of granulomatous inflammation in murine schistosomiasis. In vitro characterization of T lymphocyte subsets involved in the production and suppression of migration inhibition factor.

Lymphocyte Transformation Using Mitsuda Antigen (Lepromin)

Immunologic Responses in Patients With Lepromatous Leprosy

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