Production of L-tryptophan by microbial processes

Nyeste, L.; Pécs, Miklós; Sevella, B.; Holló, J.

doi:10.1007/bfb0001863

Cited by 5 publications

(4 citation statements)

References 39 publications

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“…92,93 The CaS receptor and GPR139 can also be activated by L-tryptophan, which can be produced by microbes. [94][95][96] The inhibitory neurotransmitter gamma-aminobutyric acid (GABA) is an agonist of the metabotropic GPCR GABA B (GPR51) and can be produced by bacterial species. 97,98 The activation of GABA B on human leukocytes has been shown to interfere with chemotaxis induced by chemokine receptors and reduce production of TNFα by macrophages.…”

Section: G Protein -Coupled Recep Tor Smentioning

confidence: 99%

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Immunomodulation by foods and microbes: Unravelling the molecular tango

Forde

Shaha

et al. 2022

Allergy

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Metabolic health and immune function are intimately connected via diet and the microbiota. Nearly 90% of all immune cells in the body are associated with the gastrointestinal tract and these immune cells are continuously exposed to a wide range of microbes and microbial‐derived compounds, with important systemic ramifications. Microbial dysbiosis has consistently been observed in patients with atopic dermatitis, food allergy and asthma and the molecular mechanisms linking changes in microbial populations with disease risk and disease endotypes are being intensively investigated. The discovery of novel bacterial metabolites that impact immune function is at the forefront of host‐microbe research. Co‐evolution of microbial communities within their hosts has resulted in intertwined metabolic pathways that affect physiological and pathological processes. However, recent dietary and lifestyle changes are thought to negatively influence interactions between microbes and their host. This review provides an overview of some of the critical metabolite‐receptor interactions that have been recently described, which may underpin the immunomodulatory effects of the microbiota, and are of relevance for allergy, asthma and infectious diseases.

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Section: G Protein -Coupled Recep Tor Smentioning

confidence: 99%

“…The calcium‐sensing (CaS) receptor has been shown to be stimulated by spermine, spermidine and putrescine and these bacterial‐derived metabolites can influence airway inflammation in murine models 92,93 . The CaS receptor and GPR139 can also be activated by L‐tryptophan, which can be produced by microbes 94–96 …”

Section: G Protein‐coupled Receptorsmentioning

confidence: 99%

Immunomodulation by foods and microbes: Unravelling the molecular tango

Forde

Shaha

et al. 2022

Allergy

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“…There are five enzymes that are involved in the biosynthesis of tryptophan and there are five genes in the tryptophan operon in E.coli encoding polypeptide chains, which organize themselves to make these five enzymes. [11].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Tryptophan Synthase Beta Chainbetween Pyrococcus furiosus (Archaea) and Salmonella typhimurium (Proteobacteria)

Bisht¹,

Behera²,

Panda³

2011

IJBBB

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Abstract-The present investigation deals with comparative study of beta chain of the enzyme tryptophan synthase from Salmonella typhimurium and Pyrococcus furiosus. The study yielded few significant results that the sequence of beta 2 subunit (PF1706) from Pfu is closely related to the beta chain of Salmonella typhimurium in comparison to the beta 1. The phylogenetics of these two strains indicates that the beta 2 subunit plays a vital role in tryptophan synthesis in Pyrococcus furiosus. In the present investigation Salmonella typhimurium was used as a reference organism for comparative genomics of tryptophan synthase beta chain amongst a group of organisms 13 archaea and 41 proteobacteria respectively. The study reveals that most of the sequences of archaea are distantly related and was observed that there are certain sequences like pfu PF1706 which are closer to Stm that is a proteobacteria.

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“…Relatively little is known about the outer membraneofSeratia marcescens (2,10,21,23), a gram-negative bacterium, which, in contrast to E. coli, releases enzymatically active proteins into the growth medium: the propertie and kinetics of a nuclease (13,20), protease (24), and lipase (25) are under investigation. Furthermore, Serratia bacteria are relatively istant to many antibiotics (4,25).…”

mentioning

confidence: 99%