Production of itaconic acid by Pseudozyma antarctica NRRL Y-7808 under nitrogen-limited growth conditions

Levinson, William E.; Kurtzman, Cletus P.; Kuo, Tsung Min

doi:10.1016/j.enzmictec.2006.01.005

Cited by 87 publications

(56 citation statements)

References 7 publications

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“…A Candida mutant strain produced up to 42 g IA L −1 from glucose after 5 days [27] and a Rodotorula species produced 15 g IA L −1 from glucose after 7 days [41]. Levinson et al [50] reported production of IA from glucose by a new yeast strain Pseudozyma antartica NRRL 7808 with a maximum yield of 37.5% (~30 g IA from 80 g glucose L −1 ) under nitrogen-limited growth conditions. Pseudozyma species are basidiomycetes and are believed to be closely related to Utstilago [9].…”

Section: Production Of Itaconic Acid By Other Fungal and Yeast Strainsmentioning

confidence: 99%

Emerging biotechnologies for production of itaconic acid and its applications as a platform chemical

Saha¹

2017

Journal of Industrial Microbiology and Biotechnology

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Recently, itaconic acid (IA), an unsaturated C5-dicarboxylic acid, has attracted much attention as a biobased building block chemical. It is produced industrially (>80 g L) from glucose by fermentation with Aspergillus terreus. The titer is low compared with citric acid production (>200 g L). This review summarizes the latest progress on enhancing the yield and productivity of IA production. IA biosynthesis involves the decarboxylation of the TCA cycle intermediate cis-aconitate through the action of cis-aconitate decarboxylase (CAD) enzyme encoded by the CadA gene in A. terreus. A number of recombinant microorganisms have been developed in an effort to overproduce it. IA is used as a monomer for production of superabsorbent polymer, resins, plastics, paints, and synthetic fibers. Its applications as a platform chemical are highlighted. It has a strong potential to replace petroleum-based methylacrylic acid in industry which will create a huge market for IA.

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Section: Production Of Itaconic Acid By Other Fungal and Yeast Strainsmentioning

confidence: 99%

Emerging biotechnologies for production of itaconic acid and its applications as a platform chemical

Saha¹

2017

Journal of Industrial Microbiology and Biotechnology

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“…doi:10.1016/j.carbpol.2010.12.054 systems and biotechnological applications (Gombotz & Wee, 1998;Shi et al, 2005;Simpson et al, 2006). IA is one of the monomers which is obtained from renewable resources by microorganism fermentation with Aspergillus terrus and Pseudozyma antarctica using carbohydrate materials as molasses and hydrolyzed starch at low cost (Levinson, Kurtzman, & Kuo, 2006;Mahdavian, Abdollahi, Mokhtabad, Bijanzadeh, & Ziaee, 2006). It is very hydrophilic and is expected to show high biocompatibility because it is derived from natural sources.…”

Section: Introductionmentioning

confidence: 99%

pH responsive itaconic acid grafted alginate microspheres for the controlled release of nifedipine

Işıklan

İnal

Kurşun

et al. 2011

Carbohydrate Polymers

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“…Shortly thereafter, it was discovered that A. terreus also produced itaconic acid in higher quantities (Meena et al, 2010) by Ustilago maydis (Chandragiri and Sastry, 2011a), various Aspergillus species and Pseudozyma antartica (Levinson et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Production of Itaconic Acid from Jatropha curcas Seed Cake by Aspergillus terreus

et al. 2013

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Submerged substrate fermentation of Jatropha seed cake, a by-product of oil extraction from Jatropha curcas seed was carried out using Aspergillus terreus for the production of itaconic acid. The Jatropha seed cake was initially converted into fermentable sugars by dilute acid hydrolysis using 50% sulphuric acid. The rate of hydrolysis was 1.04 gL -1 . The fermentation process was carried out at room temperature, agitation of 400 rpm and three physico-chemical parameters (pH, inoculum size and substrate concentration) were varied. Itaconic acid and glucose assays were carried out by spectrophotometry and Dinitrosalicylic acid methods respectively daily. Maximum yield of itaconic acid was 48.70 gL -1 at 5 ml of inoculum size, 50% substrate concentration and pH 1.5. The residual glucose concentration increased for the first two days of fermentation after which it began to decrease as the itaconic acid concentration increased. The least concentration of itaconic acid observed was 6.00 gL -1 , obtained after 24 hours of fermentation with 4 ml inoculum size, 50% substrate concentration and at pH 1.5. The findings of this work indicate that Jatropha curcas seed cake is a suitable substrate for itaconic acid production.

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Production of itaconic acid by Pseudozyma antarctica NRRL Y-7808 under nitrogen-limited growth conditions

Cited by 87 publications

References 7 publications

Emerging biotechnologies for production of itaconic acid and its applications as a platform chemical

Emerging biotechnologies for production of itaconic acid and its applications as a platform chemical

pH responsive itaconic acid grafted alginate microspheres for the controlled release of nifedipine

Production of Itaconic Acid from Jatropha curcas Seed Cake by Aspergillus terreus

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