Production of Iron-enriched Yeast and it’s application in the treatment of iron-deficiency anemia

Abstract

Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition.Wild type strains of Saccharomyces cerevisiae have higher tolerance to inorganic iron and higher iron conversion and accumulation capacity.The aim of this study was to investigate the effect of yeast iron as a potential organic iron supplement on mice with iron deficiency anemia.60 male KM mice were randomly divided into normal control group and iron deficiency diet model group to establish IDA model. After the model was established, IDA mice were randomly divided into 5 groups: normal control group, IDA group, organic iron (Fe-Gly) group, inorganic iron (FeSO4) group and yeast iron (Fe-F8) group.Mice in the experimental group were given different kinds of iron by intragastric administration once a day for 4w.The results showed that Fe-F8 had an effective recovery function, and the body weight and hematological parameters of IDA mice returned to normal levels. The activities of malondialdehyde, superoxide dismutase, glutathione peroxidase and total antioxidant capacity in serum were increased.In addition, Fe-F8 was more effective in alleviating IDA and improving organ indices with fewer side effects compared to ferrous glycinate and ferrous sulfate groups. This study suggests that the iron-rich strain F8 may play an important role in improving IDA mice and may be developed as a new iron supplement.