Production of interferons and change of the lymphocyte subpopulation phenotype in peripheral blood at cervical papillomavirus infection

Лазаренко, Л. М.; Spivak, N. Ya.; Lakatosh, V.P.; Kryvokhatska, L; Mikhailenko, O. M.; Rudenko, A. V.; Tkáčiková, Ľudmila; Mikula, I.

doi:10.1007/bf02818683

Cited by 2 publications

(16 citation statements)

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“…Today, it is known that in the development of HPV-induced cervical dysplastic lesions, the key impact has a specific cellular immune reactivity to HPV, especially the Th1-type response of T helper cells, that develops by balancing various opposition groups of cytokine, in particular, pro- and anti-inflammatory cytokines [9,14,35,36]. This is confirmed by the fact that patients with immunodeficiency states with suppressed cellular immunity, such as AIDS, are extremely susceptible to HPV-induced cancers [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…This is confirmed by the fact that patients with immunodeficiency states with suppressed cellular immunity, such as AIDS, are extremely susceptible to HPV-induced cancers [8,9]. …”

Section: Discussionmentioning

confidence: 99%

“…The interaction of oncoproteins E6 and E7 of high oncogenic risk with intracellular factors is a key stage for induction of malignant transformation. These factors play an important role in the regulation of growth, differentiation and apoptosis, which may lead to instability of the genome and malignant transformation [6-9]. …”

Section: Overviewmentioning

confidence: 99%

“…This in turn affects the balance of cytokines Th1 and Th2 type and thus determines the main path of development of the immune response - either by Th1 or by Th2 type [9,18,19]. The carcinogenesis in HPV infection also involves Th3-type cytokine, including anti-inflammatory transforming growth factor-β (TGF-β) [20,21].…”

Section: Overviewmentioning

confidence: 99%

“…The role of pro-inflammatory cytokines is ambiguous, which can affect both the formation of the body’s immune defence in the HPV [9,22-24] and enhance the growth of transformed cells, as shown in vitro [18]. We have previously found that in cervical cancer patients with HPV with severe cervical intraepithelial neoplasia (CIN), the production of IFN-γ and IFN-α was suppressed and the production of pro-inflammatory cytokines and TGF-β increased [15].…”

Section: Overviewmentioning

confidence: 99%

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Development of biomarker panel to predict, prevent and create treatments tailored to the persons with human papillomavirus-induced cervical precancerous lesions

et al. 2014

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IntroductionHuman papillomavirus (HPV) induce many cancer conditions and cause cervical cancer, second in frequency of malignant disease in women.The aim was to develop biomarker panel for HPV-induced cervical precancerous diseases in patients infected with herpes simplex virus (HSV).Material and methodsThe study involved 71 women with cervical precancerous diseases (mean age 26 ± 5 years) revealed by colposcopic, cytomorphological, and ultrasound signs which were assessed according to the following: first group, 44 patients infected with HPV; second group, 27 HPV-negative patients; and third group, 30 healthy patients (controls). In cervical specimen, we identified HPV DNA of different oncogenic risk types by polymerase chain reaction (PCR). Enzyme-linked immunosorbent assay (ELISA) kits (JSC SPC ‘DiaprofMed’) were used for detecting antibodies to HSV1 and/or HSV2 and for determining the avidity index. The production of pro-inflammatory cytokines, interferon-γ (IFN-γ), IFN-α, TNF-α, and interleukin-1β (IL-1β), and anti-inflammatory cytokines, IL-4, IL-10, and transforming growth factor-β1 (TGF-β1), were studied by ELISA.ResultsIn HPV-induced cervix precancerous diseases, we identified low-avidity IgG antibodies to HSV serum of 20 patients; in the serum of 17 patients, we identified average-avidity antibodies, and high-avidity antibodies were found in 2 patients only. In 14 HPV-negative patients, we found low-avidity IgG antibodies to HSV; in 10 patients, medium avidity. Patients with low-avidity IgG antibodies to herpes virus showed high and medium oncogenic risk HPV types and a decrease of IFN-γ compared to patients with medium-avidity IgG antibodies. Production of IFN-γ was suppressed also in HPV-negative patients with cervical precancers, but we found low- and medium-avidity IgG antibodies to herpes virus. In patients with low-avidity antibodies, we observed increased level of IL-10. Level of IFN-α, IL-1β, IL-2, and IL-4 did not change in patients of all groups, but TGF-β1 increased.ConclusionsIn HPV-positive patients, those with low-avidity IgG antibodies to HSV had immunosuppression, confirmed by increased TGF-β1 and violation of IFN-γ production. Therefore, in pro- and anti-inflammatory cytokines and IgG antibodies to HSV, their avidity is an important diagnostic biomarker of HPV-induced precancerous cervical diseases. Low-avidity IgG antibodies may be an indication for treatment with immunomodulators and antiviral drugs.

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Section: Discussionmentioning

confidence: 99%

“…This is confirmed by the fact that patients with immunodeficiency states with suppressed cellular immunity, such as AIDS, are extremely susceptible to HPV-induced cancers [8,9]. …”

Section: Discussionmentioning

confidence: 99%

Section: Overviewmentioning

confidence: 99%

Section: Overviewmentioning

confidence: 99%

Section: Overviewmentioning

confidence: 99%

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Development of biomarker panel to predict, prevent and create treatments tailored to the persons with human papillomavirus-induced cervical precancerous lesions

et al. 2014

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Peripheral blood lymphocytes influence human papillomavirus infection and clearance: a retrospective cohort study

Feng

Chen

et al. 2023

Virol J

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Background There is a close correlation between HPV infection and systemic immune status. The purpose of this study was to determine which lymphocytes in peripheral blood influence human papillomavirus (HPV) infection and to identify whether peripheral blood lymphocyte (PBL) subsets could be used as biomarkers to predict HPV clearance in the short term. Methods This study involved 716 women undergoing colposcopy from 2019 to 2021. Logistic and Cox regression were used to analyze the association of PBLs with HPV infection and clearance. Using Cox regression, bidirectional stepwise regression and the Akaike information criterion (AIC), lymphocyte prediction models were developed, with the C-index assessing performance. ROC analysis determined optimal cutoff values, and their accuracy for HPV clearance risk stratification was evaluated via Kaplan‒Meier and time-dependent ROC. Bootstrap resampling validated the model and cutoff values. Results Lower CD4 + T cells were associated with a higher risk of HPV, high-risk HPV, HPV18 and HPV52 infections, with corresponding ORs (95% CI) of 1.58 (1.16–2.15), 1.71 (1.23–2.36), 2.37 (1.12–5.02), and 3.67 (1.78–7.54), respectively. PBL subsets mainly affect the natural clearance of HPV, but their impact on postoperative HPV outcomes is not significant (P > 0.05). Lower T-cell and CD8 + T-cell counts, as well as a higher NK cell count, are unfavorable factors for natural HPV clearance (P < 0.05). The optimal cutoff values determined by the PBL prognostic model (T-cell percentage: 67.39%, NK cell percentage: 22.65%, CD8 + T-cell model risk score: 0.95) can effectively divide the population into high-risk and low-risk groups, accurately predicting the natural clearance of HPV. After internal validation with bootstrap resampling, the above conclusions still hold. Conclusions CD4 + T cells were important determinants of HPV infection. T cells, NK cells, and CD8 + T cells can serve as potential biomarkers for predicting natural HPV clearance, which can aid in patient risk stratification, individualized treatment, and follow-up management.

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Production of interferons and change of the lymphocyte subpopulation phenotype in peripheral blood at cervical papillomavirus infection

Cited by 2 publications

References 12 publications

Development of biomarker panel to predict, prevent and create treatments tailored to the persons with human papillomavirus-induced cervical precancerous lesions

Development of biomarker panel to predict, prevent and create treatments tailored to the persons with human papillomavirus-induced cervical precancerous lesions

Peripheral blood lymphocytes influence human papillomavirus infection and clearance: a retrospective cohort study

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