Production of innovative radionuclides for medical applications at the CERN-MEDICIS facility

Bernerd, Cyril; J.D., Johnson,; Aubert, Emilie; Au, M.; Barozier, Vincent; Bernardes, A. P.; Bertreix, Philippe; Bruchertseifer, Frank; Catherall, R.; Chevallay, E.; Chrysalidis, K.; Christodoulou, Prokopis; Cocolios, T. E.; Crepieux, B.; Deschamps, Marcelo; Dorsival, A.; Duchemin, Charlotte; Fedosseev, V. N.; Fernier, P.; Heines, Michael; Heinke, Reinhard; Khalid, Umair; Khan, Mumtaz; Khan, Qamar Alam; Lambert, Laura; Mamis, Edgars; Marsh, B. A.; Marzari, S.; Menaa, N.; Munos, M.; Pozzi, Fabio; Prvakova, S.; Ramos, J.P.; Riccardi, F; Rinchet, Jean-Yves; Rossel, R. E.; Stora, T.; Thiboud, J.; Vollaire, J.; Bergh, V. Van Den; Wojtaczka, W.

doi:10.1016/j.nimb.2023.05.008

Cited by 2 publications

(3 citation statements)

References 34 publications

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“…The most common thick-target materials used at ISOLDE for radioactive ion beam production are uranium carbide (UC

) or metallic natural tantalum (

Ta) foils [ 32 , 33 ], which are also used at MEDICIS for radiolanthanide production and mass separation [ 34 ]. Various forms of

Ti and

V target materials capable of producing Sc isotope beams have been used at ISOLDE in the past 40 years [ 32 ] and are summarized in Table 2 .…”

Section: Thick Targets and Mass Separatormentioning

confidence: 99%

“…Before the bending magnet, a copper Faraday cup is inserted into the beam path to measure the total beam current entering the dipole magnet. The beam instrumentation box after the magnet houses a wire scanner to assess the beam shape and position, another Faraday cup to measure the separated beam current, and a recently upgraded double-slit system, which allows for isolating single or two-ion different-mass ion beams simultaneously, with a mass difference of 1–3 amu [ 34 ]. Last on the beamline is the sample collection chamber, where the sample holder with up to three collection foils (15 × 20 mm) is placed in the radioactive ion beam path to implant the isotope(s) of interest.…”

Section: Thick Targets and Mass Separatormentioning

confidence: 99%

“…Obtained TTYs for MEDICIS targets are relatively higher due to target thickness; however, the MEDICIS target materials are irradiated with a 2

A proton beam whereas cyclotrons can reach up to 100–350

A intensities, eventually placing both irradiation modes in the same yield range. One should note that to estimate achievable activity per production run, the possibility of increasing the cyclotron target thickness as well as the mass separation efficiency (0.1–50%, depending on the chemical element) should be taken into account [ 34 , 54 ].…”

Section: Scandium Radionuclide Production Yieldsmentioning

confidence: 99%

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Target Development towards First Production of High-Molar- Activity 44gSc and 47Sc by Mass Separation at CERN-MEDICIS

Mamis,

Duchemin,

Berlin

et al. 2024

Pharmaceuticals

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The radionuclides 43Sc, 44g/mSc, and 47Sc can be produced cost-effectively in sufficient yield for medical research and applications by irradiating natTi and natV target materials with protons. Maximizing the production yield of the therapeutic 47Sc in the highest cross section energy range of 24–70 MeV results in the co-production of long-lived, high-γ-ray-energy 46Sc and 48Sc contaminants if one does not use enriched target materials. Mass separation can be used to obtain high molar activity and isotopically pure Sc radionuclides from natural target materials; however, suitable operational conditions to obtain relevant activity released from irradiated natTi and natV have not yet been established at CERN-MEDICIS and ISOLDE. The objective of this work was to develop target units for the production, release, and purification of Sc radionuclides by mass separation as well as to investigate target materials for the mass separation that are compatible with high-yield Sc radionuclide production in the 9–70 MeV proton energy range. In this study, the in-target production yield obtained at MEDICIS with 1.4 GeV protons is compared with the production yield that can be reached with commercially available cyclotrons. The thick-target materials were irradiated at MEDICIS and comprised of metallic natTi, natV metallic foils, and natTiC pellets. The produced radionuclides were subsequently released, ionized, and extracted from various target and ion source units and mass separated. Mono-atomic Sc laser and molecule ionization with forced-electron-beam-induced arc-discharge ion sources were investigated. Sc radionuclide production in thick natTi and natV targets at MEDICIS is equivalent to low- to medium-energy cyclotron-irradiated targets at medically relevant yields, furthermore benefiting from the mass separation possibility. A two-step laser resonance ionization scheme was used to obtain mono-atomic Sc ion beams. Sc radionuclide release from irradiated target units most effectively could be promoted by volatile scandium fluoride formation. Thus, isotopically pure 44g/mSc, 46Sc, and 47Sc were obtained as mono-atomic and molecular ScF 2+ ion beams and collected for the first time at CERN-MEDICIS. Among all the investigated target materials, natTiC is the most suitable target material for Sc mass separation as molecular halide beams, due to high possible operating temperatures and sustained release.

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“…The most common thick-target materials used at ISOLDE for radioactive ion beam production are uranium carbide (UC

) or metallic natural tantalum (

Ta) foils [ 32 , 33 ], which are also used at MEDICIS for radiolanthanide production and mass separation [ 34 ]. Various forms of

Ti and

V target materials capable of producing Sc isotope beams have been used at ISOLDE in the past 40 years [ 32 ] and are summarized in Table 2 .…”

Section: Thick Targets and Mass Separatormentioning

confidence: 99%

Section: Thick Targets and Mass Separatormentioning

confidence: 99%

“…Obtained TTYs for MEDICIS targets are relatively higher due to target thickness; however, the MEDICIS target materials are irradiated with a 2

A proton beam whereas cyclotrons can reach up to 100–350

Section: Scandium Radionuclide Production Yieldsmentioning

confidence: 99%

See 1 more Smart Citation

Target Development towards First Production of High-Molar- Activity 44gSc and 47Sc by Mass Separation at CERN-MEDICIS

Mamis,

Duchemin,

Berlin

et al. 2024

Pharmaceuticals

Self Cite

View full text Add to dashboard Cite

show abstract

Scandium thermal release from activated natTi and natV target materials i

Mamis,

Kalnina,

Duchemin

et al. 2024

Nuclear Instruments and Methods in Physics Research Section B:

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Production of innovative radionuclides for medical applications at the CERN-MEDICIS facility

Cited by 2 publications

References 34 publications

Target Development towards First Production of High-Molar- Activity 44gSc and 47Sc by Mass Separation at CERN-MEDICIS

Target Development towards First Production of High-Molar- Activity 44gSc and 47Sc by Mass Separation at CERN-MEDICIS

Scandium thermal release from activated natTi and natV target materials i

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