Production of IL-10, TNF and IL-12 by Peripheral Blood Mononuclear Cells in Mexican Workers Exposed to a Mixture of Benzene–Toluene–Xylene

Haro-García, Luis; Juárez-Pérez, Cuauhtémoc Arturo; Aguilar-Madrid, Guadalupe; Vélez-Zamora, Nadia Mayola; Muñoz‒Navarro, Sergio; Chacón‐Salinas, Rommel; González-Bonilla, César; Iturbe-Haro, Claudia Rosa; Estrada-Garcı́a, Iris; Borja-Aburto, Víctor Hugo

doi:10.1016/j.arcmed.2012.01.008

Cited by 16 publications

(9 citation statements)

References 39 publications

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“…Toluene occupational exposure has also been claimed as a deregulator of TNF-α production in white blood cells (Haro-García et al, 2012). Present results (Table 3) suggest that the obesity-dependent increase of TNF-α production in exposed people raises the risk for a chronic inflammatory state, making it a vicious circle.…”

Section: Body Mass Index and Promoter Methylation Correlationmentioning

confidence: 68%

“…Human toluene exposure has been related with peripheral and central neurotoxicity (Shih et al, 2011;Gupta et al, 2011), nephrotoxicity (González-Yebra et al, 2006;Voss et al, 2005), respiratory system disease (Al-Batanony et al, 2012;Yoon et al, 2010), immune system alterations (Haro-García et al, 2012;Bulog et al, 2011) and effects on reproductive system (Hannigan and Bowen, 2010;Bukowski, 2001). Some of these studies found adverse toluene effects not only in lowlevel occupational exposure but also in individuals living at home where indoor, chronic toluene exposure has been observed.…”

Section: Introductionmentioning

confidence: 93%

“…Molecular basis of adverse health effects from toluene exposure in humans are not fully elucidated. Human and cell-culture studies have implicated oxidative stress, inflammation and induction of apoptosis in toluene induced toxicity (Haro-García et al, 2012;Sarma et al, 2011;Mögel et al, 2011;Kim et al, 2011). Toluene has also shown genotoxic effects (Moro et al, 2012;Cassini et al, 2011;Rekhadevi et al, 2010;González-Yebra et al, 2009) and an increased risk of developing hematologic malignancies (Breccia et al, 2012;Cocco et al, 2010;Costantini et al, 2008;Jung et al, 2007).…”

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: Relationship with oxidative stress and smoking habit

Jiménez-Garza

Baccarelli²,

Byun³

et al. 2015

Toxicology and Applied Pharmacology

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Section: Body Mass Index and Promoter Methylation Correlationmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: Relationship with oxidative stress and smoking habit

Jiménez-Garza

Baccarelli²,

Byun³

et al. 2015

Toxicology and Applied Pharmacology

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“…Neither benzene urinary metabolites nor cumulative benzene exposure was associated with any cytokine level [28]. Later, a Mexican study [29] evaluated the relationship between occupational exposure to benzene-toluene-xylene mixture (BTX) and IL-10, TNF, and IL-12 production by peripheral blood mononuclear cells. The study involved 54 workers divided into two exposure groups: high and low BTX accumulated potential dose.…”

Section: Introductionmentioning

confidence: 99%

“…The study involved 54 workers divided into two exposure groups: high and low BTX accumulated potential dose. Workers highly exposed to BTX showed a significant fall in TNF production; although without statistical significance, a reduction for IL-10 and IL-12 was also observed [29]. A recent Italian study [30] evaluated IL-10 serum levels in 51 oil refinery employees exposed to benzene and in 16 nonexposed office workers who resided in the same area.…”

Section: Introductionmentioning

confidence: 99%

Cytokine Network Involvement in Subjects Exposed to Benzene

Minciullo

Navarra

Calapai

et al. 2014

Journal of Immunology Research

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Benzene represents an ubiquitous pollutant both in the workplace and in the general environment. Health risk and stress posed by benzene have long been a concern because of the carcinogenic effects of the compound which was classified as a Group 1 carcinogen to humans and animals. There is a close correlation between leukemia, especially acute myeloid leukemia, and benzene exposure. In addition, exposure to benzene can cause harmful effects on immunological, neurological, and reproductive systems. Benzene can directly damage hematopoietic progenitor cells, which in turn could lead to apoptosis or may decrease responsiveness to cytokines and cellular adhesion molecules. Alternatively, benzene toxicity to stromal cells or mature blood cells could disrupt the regulation of hematopoiesis, including hematopoietic commitment, maturation, or mobilization, through the network of cytokines, chemokines, and adhesion molecules. Today there is mounting evidence that benzene may alter the gene expression, production, or processing of several cytokines in vitro and in vivo. The purpose of this review was to systematically analyze the published cases of cytokine effects on human benzene exposure, particularly hematotoxicity, and atopy, and on lungs.

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Immunotoxicology in Industrial Hygiene and Occupational Exposures

2023

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Immunotoxicology is the study of drugs and chemicals that produce adverse effects on the immune system. Adverse immune effects include suppression, leading to compromised ability to fight infections, or enhancement, which could be involved in hypersensitivity (allergy) or autoimmunity. It has been appreciated for hundreds of years that diseases are associated with various occupations, such as respiratory diseases in those working with grains, coal, metals, or animals. We now understand that many of these occupational diseases are the result of an unregulated immune response to a specific agent. Similarly, occupational exposures to various chemicals can produce dermatitis, again due in part to unregulated immune responses in the skin. Additionally, occupational chemical exposures have been demonstrated to induce immune suppression. This chapter provides an overview of the immune system, a synopsis of standard assays to evaluate immunotoxic potential of occupational chemicals, and descriptions of effects of several occupational immunotoxicants with a focus on human exposures and doses. Consideration is given to current data gaps and potential use of novel technologies to more precisely define effects and mechanisms of occupational immunotoxicants.

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Production of IL-10, TNF and IL-12 by Peripheral Blood Mononuclear Cells in Mexican Workers Exposed to a Mixture of Benzene–Toluene–Xylene

Cited by 16 publications

References 39 publications

CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: Relationship with oxidative stress and smoking habit

CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: Relationship with oxidative stress and smoking habit

Cytokine Network Involvement in Subjects Exposed to Benzene

Immunotoxicology in Industrial Hygiene and Occupational Exposures

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