Production of Lactobacillus plantarum ghosts by conditional expression of a prophage-encoded holin
Pinpunya Riangrungroj,
Wonnop Visessanguan,
Ubolsree Leartsakulpanich
Abstract:Bacterial ghosts (BGs) are non-viable empty bacterial cell envelopes with intact cellular morphology and native surface structure. BGs made from pathogenic bacteria are used for biomedical and pharmaceutical applications. However, incomplete pathogenic cell inactivation during BG preparation raises safety concerns that could limit the intended use. Therefore, safer bacterial cell types are needed for BG production. Here, we produced BGs from the food-grade Gram-positive bacterium Lactobacillus plantarum TBRC 2… Show more
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