Production of <i>cis</i>
-11-eicosenoic acid by <i>Mortierella</i>
 fungi

Kikukawa, Hiroshi; Sakuradani, Eiji; Nishibaba, Y.; Okuda, Takuo; Ando, Akinori; Shima, Jun; Shimizu, Sakayu; Ogawa, Jun

doi:10.1111/jam.12725

Cited by 14 publications

(4 citation statements)

References 20 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aforementioned acid serves as a primary constituent for the production of medical supplies and is also employed as a moisturizing agent in cosmetic formulations. (Kikukawa et al, 2015). The presence of Eicosenoic acid in the leaves of the altar plant, cultivated in the regions of Aqra and Mosul, was confirmed through the analysis of chromatograms.…”

Section: Separation and Identification Of A Number Of Fatty Acids By ...mentioning

confidence: 86%

Detection of Fatty Acids Separated from Melissa Officinalis Leaves Using GLC Technology and Studying their Effect on the Vitality of Staphylococcus Aureus

Mahmoud,

Mikhlif,

Hasan

2023

JLL

View full text Add to dashboard Cite

The plant found in Mosul exhibited distinct characteristics in terms of its composition of Undecanoic acid and Linoleic acid. Notably, the highest concentration of fatty acids was observed in the leaves of the plant cultivated in the Aqrah district, measuring 9.908 mg/g. The findings of the present study demonstrate that fatty acids exhibit antioxidant properties against the free radical DPPH. Moreover, it was observed that the efficacy of these fatty acids in neutralizing the free radical increases proportionally with the concentration of the active compounds. At a concentration of 500 μg/ml, the fatty acids (Mosul) exhibited the highest level of inhibition, with a rate of 86.4%. This inhibition rate was found to be superior to that of fatty acids (Aqrah) at the same concentration, which showed an inhibition rate of 79.25%. Furthermore, the observed inhibition rate of fatty acids (Mosul) was statistically significant and comparable to the standard sample of ascorbic acid at the same concentration, which exhibited an inhibition rate of 85.6%. Following these results, the concentration of fatty acids (Mosul) is 400 micrograms per milliliter, exhibiting an inhibition rate of 81.2%. In comparison, fatty acids (Aqrah) achieved an inhibition rate of 72.3% at the same concentration. Other concentrations displayed varying degrees of inhibition capacity towards DPPH free radicals. The study provided confirmation of the inhibitory effects of fatty acids on the viability of Staphylococcus aureus strains isolated from infected individuals at Tikrit Teaching Hospital.

show abstract

Section: Separation and Identification Of A Number Of Fatty Acids By ...mentioning

confidence: 86%

Detection of Fatty Acids Separated from Melissa Officinalis Leaves Using GLC Technology and Studying their Effect on the Vitality of Staphylococcus Aureus

Mahmoud,

Mikhlif,

Hasan

2023

JLL

View full text Add to dashboard Cite

show abstract

“…Along with usual fatty acids (e.g., palmitic acid, linoleic acid, stearic acid, and arachidonic acid), several unusual fatty acids (e.g., gondoic acid, behenic acid) were detected. In this respect, gondoic acid ( cis -11-eicosenoic acid) is a very rare monounsaturated fatty acid reported from plants and only occasionally from fungi [ 47 ]. The mycelium of the strain under examination also contains arabitol, a polyol commonly produced by microorganisms, which is an integral part of their normal growth process.…”

Section: Discussionmentioning

confidence: 99%

Screening of Secondary Metabolites Produced by Nigrospora sphaerica Associated with the Invasive Weed Cenchrus ciliaris Reveals Two New Structurally Related Compounds

Salvatore,

Russo,

Meyer

et al. 2024

Molecules

View full text Add to dashboard Cite

In the search for new alternative biocontrol strategies, phytopathogenic fungi could represent a new frontier for weed management. In this respect, as part of our ongoing work aiming at using fungal pathogens as an alternative to common herbicides, the foliar pathogen Nigrospora sphaerica has been evaluated to control buffelgrass (Cenchrus ciliaris). In particular, in this work, the isolation and structural elucidation of two new biosynthetically related metabolites, named nigrosphaeritriol (3-(hydroxymethyl)-2-methylpentane-1,4-diol) and nigrosphaerilactol (3-(1-hydroxyethyl)-4-methyltetrahydrofuran-2-ol), from the phytotoxic culture filtrate extract were described, along with the identification of several known metabolites. Moreover, the absolute stereochemistry of (3R,4S,5S)-nigrosphaerilactone, previously reported as (3S,4R,5R)-4-hydroxymethyl-3,5-dimethyldihydro-2-furanone, was determined for the first time by X-ray diffraction analysis. Considering their structural relationship, the determination of the absolute stereochemistry of nigrosphaerilactone allowed us to hypothesize the absolute stereochemistry of nigrosphaeritriol and nigrosphaerilactol.

show abstract

“…[ 79,171 ] Currently, DES research centers mainly on metabolic engineering of target organisms to produce natural fatty acids at increased yield or purity. [ 172–175 ] However, the sequence‐structure–function relationship leading to the diverse functionality and substrate range of the DES family is still elusive and (semi‐) rational enzyme engineering is therefore currently out of reach. Additionally, limited understanding of the essential function of unsaturated fatty acids, their general position at the end of the biochemical fatty acid pathway and the low expression levels of DES make the design of directed evolution experiments to engineer specific DES properties challenging.…”

Section: Summary and Biotechnological Implicationsmentioning

confidence: 99%

Integral Membrane Fatty Acid Desaturases: A Review of Biochemical, Structural, and Biotechnological Advances

Nachtschatt

Okada

Speight

2020

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

Sustainably produced platform chemicals are increasingly sought after. Fatty acids containing olefinic and hydroxy groups are particularly interesting as platform chemicals for regio-and stereo-selective downstream reactions. Integral membrane fatty acid desaturases can selectively introduce double bonds or catalyze unusual reactions such as acetylenation, conjugation, hydroxylation, and epoxidation. Here, a systematic overview of recent achievements and key literature of integral membrane desaturases is provided in the context of biotechnological potential of the enzyme family. Practical Application: Integral membrane fatty acid desaturases may be the most promising tool to increase the scope of fatty acids as platform chemicals. Plant oil production is well researched and an established sustainable pathway toward high-yield chemicals. In addition, effort is increasing toward creating microbial high-yield oil producers. The current bottleneck is the limited fatty acid species that can be produced at high yields. It is envisioned that future enzyme engineering work will enable the targeted design of desaturases to produce modified fatty acids that follow industry needs. This review provides a systematic overview of the natural diversity and complexity of integral membrane fatty acid desaturases to help researchers expand existing fatty acid production beyond currently utilized fatty acid species.

show abstract

Production of cis -11-eicosenoic acid by Mortierella fungi

Abstract: EA is beneficial as a raw material for medical supplies and a moisturizing component of cosmetic creams. This is the first report of microbial production of EA.

Cited by 14 publications

References 20 publications

Detection of Fatty Acids Separated from Melissa Officinalis Leaves Using GLC Technology and Studying their Effect on the Vitality of Staphylococcus Aureus

Detection of Fatty Acids Separated from Melissa Officinalis Leaves Using GLC Technology and Studying their Effect on the Vitality of Staphylococcus Aureus

Screening of Secondary Metabolites Produced by Nigrospora sphaerica Associated with the Invasive Weed Cenchrus ciliaris Reveals Two New Structurally Related Compounds

Integral Membrane Fatty Acid Desaturases: A Review of Biochemical, Structural, and Biotechnological Advances

Contact Info

Product

Resources

About