Production of Hepatitis B Surface Antigen in Recombinant Plant Systems: An Update

Kumar, Gaurav; Ganapathi, T. R.; Bapat, V. A.

doi:10.1021/bp0602754

Cited by 33 publications

(19 citation statements)

References 33 publications

(42 reference statements)

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“…Recombinant subunit vaccines have proven to be safe and effective in many clinical and post-clinical studies, such as human vaccines against hepatitis B virus, human papillomavirus and hepatitis E virus [16][17][18]. In the case of rotavirus, VP2/6/7 or VP2/6/4/7 triple-layered virus-like particles (VLPs) [19,20], VP2/6 doublelayered VLPs [21] and VP6 subunit protein [22,23] eukaryotic cells have proven to be effective against rotavirus induced diarrhea or virus shedding in small animal models.…”

Section: Introductionmentioning

confidence: 99%

Characterization and protective efficacy in an animal model of a novel truncated rotavirus VP8 subunit parenteral vaccine candidate

Xue

Che

et al. 2015

Vaccine

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Section: Introductionmentioning

confidence: 99%

Characterization and protective efficacy in an animal model of a novel truncated rotavirus VP8 subunit parenteral vaccine candidate

Xue

Che

et al. 2015

Vaccine

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“…Plant delivery of oral vaccines has attracted much attention because this strategy offers several advantages over vaccine delivery by injection [65][66][67]. Oral vaccines also offer the hope of more convenient immunization strategies and a more practical means of implementing universal vaccination programs worldwide.…”

Section: Vaccine Deliverymentioning

confidence: 99%

Transgenic Vegetable Breeding for Nutritional Quality and Health Benefits

Dias¹,

Ortíz

2012

FNS

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Vegetables are essential for well-balanced diets. About 3 billion people in the world are malnourished due to imbalanced diets. Vegetables can contribute to the prevention of malnutrition disorders. Genetic engineering enables vegetable breeders to incorporate desired transgenes into elite cultivars, thereby improving their value considerably. It further offers unique opportunities for improving nutritional quality and bringing other health benefits. Many vegetable crops have been genetically modified to improve traits such as higher nutritional status or better flavour, and to reduce bitterness or anti-nutritional factors. Transgenic vegetables can be also used for vaccine delivery. Consumers could benefit further from eating more nutritious transgenic vegetables, e.g. an increase of crop carotenoids by metabolic sink manipulation through genetic engineering appears feasible in some vegetables. Genetically engineering carrots containing increase Ca levels may boost Ca uptake, thereby reducing the incidence of Ca deficiencies such as osteoporosis. Fortified transgenic lettuce with zinc will overcome the deficiency of this micronutrient that severely impairs organ function. Folates deficiency, which is regarded as a global health problem, can also be overcome with transgenic tomatoes with folate levels that provide a complete adult daily requirement. Transgenic lettuce with improved tocopherol and resveratrol composition may prevent coronary disease and arteriosclerosis and can contribute to cancer chemopreventative activity. Food safety and health benefits can also be enhanced through transgenic approaches, e.g. rural African resource-poor consumers will benefit eating cyanide-free cultivars of cassava. Biotechnology-derived vegetable crops will succeed if clear advantages and safety are demonstrated to both growers and consumers.

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“…As noted above, many other approaches have been applied to naïve and nonresponder populations. Some of the more cuttingedge ideas include nanoparticle-based systems and even the development of an oral hepatitis B vaccine using recombinant plant systems [8,9].…”

Section: Commentsmentioning

confidence: 99%

Hepatitis B vaccine nonresponders: A role for revaccination with the combination hepatitis A/B vaccine?

Bobak¹

2009

Curr Infect Dis Rep

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Excellent response rate to a double dose of the combined hepatitis A and B vaccine in previous nonresponders to hepatitis B vaccine. J Infect Dis 2008, 198:299-304. Rating: • Of importance.Introduction: Infection with hepatitis B virus (HBV) is widespread. Chronic HBV infection is a particular problem because it is associated with a signifi cant risk of developing cirrhosis or hepatocellular cancer [1,2]. Immunization with one of the commercially available hepatitis B vaccines is effective in preventing acquisition of HBV infection and 95% or more of individuals receiving the three-dose vaccine regimen develop an acceptable level of antibody to hepatitis B surface antigen (anti-HbsAg) [3][4][5]. For most populations, this level of response is believed to be adequate. However, in certain higher risk groups (eg, health care workers) an attempt to revaccinate nonresponders is generally warranted. Despite a variety of alterations in vaccine type, adjuvant addition, dosing regimen, and mechanism of administration, no clear-cut method to effectively immunize nonresponders has emerged.

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Production of Hepatitis B Surface Antigen in Recombinant Plant Systems: An Update

Cited by 33 publications

References 33 publications

Characterization and protective efficacy in an animal model of a novel truncated rotavirus VP8 subunit parenteral vaccine candidate

Characterization and protective efficacy in an animal model of a novel truncated rotavirus VP8 subunit parenteral vaccine candidate

Transgenic Vegetable Breeding for Nutritional Quality and Health Benefits

Hepatitis B vaccine nonresponders: A role for revaccination with the combination hepatitis A/B vaccine?

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