Production of Granulocyte Colony-Stimulating Factor and Parathyroid Hormone-Related Protein in Squamous Cell Carcinoma of the Renal Pelvis Accompanied With Inferior Vena Cava Thrombus

Abstract

A 54-year-old man with general fatigue and lumbago was admitted for further examination of hypercalcemia and leukocytosis. CT showed a huge renal tumor and extension of the tumor thrombus to the inferior vena cava (IVC). Moreover, the serum granulocyte colony-stimulating factor (G-CSF) and the C-terminal of parathyroid hormone-related protein (PTHrP) were elevated. Under the diagnosis of advanced renal tumor, we performed nephro-ureterectomy and throbectomy. Pathological examination revealed squamous cell carcinoma of the renal pelvis. To our knowledge, this is the first case in Japan that of the simultaneous production of G-CSF and PTHrP in squamous cell carcinoma of the renal pelvis accompanied with IVC thrombus.

Renal pelvis squamous cell carcinoma with inferior vena cava infiltration: Case report and review of the literature

“…The spread to the surrounding vasculature is not uncommon as the patients tend to present late, with the spread including that of the hilar vessels and the IVC. In the last 20 years, only 11 9–17 cases of vascular involvement of the RSCC tumor have been reported, of which 8 9,10,14–17 cases involved both renal vein and inferior vena cava, and 3 11–13 cases only the renal vein. However, the management of the vascular involvement of the tumor was not discussed in-depth in these cases.…”