Production of functional human nerve growth factor from the submandibular glands of mice using a CRISPR/Cas9 genome editing system

The Effect Of Molecular Genetic Mechanisms On Drug Addiction And Related New Generation CRISPR Gene Engineering Applications

“…Mouse NGF has long been used for neuronal and non-neuronal disorders. With the help of the CRISPR/Cas9 system, transgenic mice were generated that express human NGF (hNGF) especially in their submandibular glands (Gu et al, 2020). CRISPR/Cas-based genome editing tools may provide an important solution in the future for understanding and defining neuronal circuits and set light to mysteries of complex neurological disorders (Heidenreich and Zhang, 2016).…”