Production of factors involved into fibrosis regulation by various types of human macrophages

Максимова, Анастасия Алексеевна; Shevela, Е. Ya.; Сахно, Л. В.; Останин, А. А.; Черных, Е. Р.

doi:10.15789/1563-0625-pof-1954

Cited by 3 publications

(6 citation statements)

References 35 publications

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“…Выступающие в деструктивной фазе воспаления как сигнальные и защитные клетки, макрофаги, которые могут приводить к необратимой дегенерации соединительной ткани, меняют на последующих этапах свой «воспалительный» фенотип на «репаративный» [6,10]. При их активном участии происходит резорбция поврежденной ткани, модулируется фиброгенез [6].…”

Section: Molecular Cellular Reactions Of the Respiratory Tract To Col...unclassified

“…При их активном участии происходит резорбция поврежденной ткани, модулируется фиброгенез [6]. Ключевую роль данных клеток в регуляции фиброгенеза связывают со стадией фибротического процесса и функциональным фенотипом макрофагов [6,10].…”

Section: Molecular Cellular Reactions Of the Respiratory Tract To Col...unclassified

“…Считается, что продукция факторов фибро-и коллагеногенеза, приводящая к ремоделированию бронхов у больных БА, в значительной степени обусловлена Тh2 иммунным ответом, индукцией экспрессии активатора секреции Th2 цитокинов транскрипционного фактора GATA-3 [11], «противовоспалительным», альтернативным классическому М2 путем активации и М2 поляризацией макрофагов, контролируемых интерлейкинами (IL)-4, IL-5, IL-9 и IL-13 [3,5,12]. Между тем, репаративными свойствами обладают и макрофаги М1 фенотипа, способные секретировать VEGF (vascular endothelium growth factor), стимулирующий ангиогенез и образование грануляционной ткани, плейотропные цитокины (IL-6, IL-2, TNF-α), про-и антифиброгенные факторы, включающие MMPs и TIMPs [2,10]. ММР-9 расценивается как наиболее значимая профиброгенная металлопротеиназа, способствующая высвобождению связанных с внеклеточным матриксом ангиогенных факторов, таких как VEGF [7,10].…”

Section: Molecular Cellular Reactions Of the Respiratory Tract To Col...unclassified

“…Между тем, репаративными свойствами обладают и макрофаги М1 фенотипа, способные секретировать VEGF (vascular endothelium growth factor), стимулирующий ангиогенез и образование грануляционной ткани, плейотропные цитокины (IL-6, IL-2, TNF-α), про-и антифиброгенные факторы, включающие MMPs и TIMPs [2,10]. ММР-9 расценивается как наиболее значимая профиброгенная металлопротеиназа, способствующая высвобождению связанных с внеклеточным матриксом ангиогенных факторов, таких как VEGF [7,10].…”

Section: Molecular Cellular Reactions Of the Respiratory Tract To Col...unclassified

“…Координация макрофагами поздней стадии воспаления базируется на продукции ростовых факторов (VEGF, TGF-β (Transforming Growth Factor), IGF-1 (Insulin-like Growth Factor), PDGF (Platelet-derived Growth Factor)), стимуляции ангиогенеза, пролиферации фибробластов, резидентных прогениторных клеток фибробластического ряда и миофибробластов, дифференцировке клеток-предшественников в миофибробласты, синтезе компонентов внеклеточного матрикса, преимущественно коллагена [8,10]. TNF-α выступает потенциальным индуктором или маркером [8,10].…”

Section: таблица 2 содержание Tnf-α ммр-9 и Timp-1 в конденсате выдых...unclassified

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Molecular cellular reactions of the respiratory tract to cold stimulus in non-allergic bronchial asthma

Pirogov,

Prikhodko,

Pirogova

et al. 2024

Bûlletenʹ fiziologii i patologii dyhaniâ

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Introduction. Macrophages, matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor-alpha (TNF-α) make a significant contribution to the pathophysiological mechanisms of development and course of bronchial asthma.Aim. To evaluate the role of macrophages and MMP-9 regulated by TNF-α signaling in the formation of airway response of non-allergic bronchial asthma patients to cold air hyperventilation.Materials and methods. Spirometric indices of forced expiratory flow, cellular composition of sputum, MMP-9 and TNF-α content in exhaled breath condensate (EBC) were measured in 66 patients with asthma before and after bronchoprovocation test with isocapnic hyperventilation with cold (-20°C) air (IHCA) were evaluated.Results. Two groups of patients with presence (group 1) or absence (group 2) of cold airway hyperresponsiveness were formed. High macrophage and neutrophil counts and a significant decrease in the number of epithelial cells in sputum were recorded after the IHCA. Concentrations of TNF-α and MMP-9 in EBC after IHCA decreased to a greater extent in patients of group 2. The content of epitheliocytes in sputum was correlated with FEF50 (r=-0.49, p=0.03), FEF75 (r=-0.45, p=0.047) and MEF25-75 (r=-0.47, p=0.038), and their content after IHCA test with ΔMEF25-75 (Rs=0.31; p=0.018). We found a correlation between baseline MMP-9 content in EBC and ΔMEF25-75 (Rs=-0.59; p=0.042), as well as between MMP-9 level after IHCA and severity of bronchospasm (ΔMEF25-75) in response to IHCA test (Rs=-0.67; p=0.023).Conclusion. In patients with cold airway hyperresponsiveness, uncontrolled course of asthma and more significant bronchial patency disorders are associated with productive-proliferative inflammation involving macrophages, MMP-9 and TNF-α, which contributes to bronchial remodeling.

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Section: Molecular Cellular Reactions Of the Respiratory Tract To Col...unclassified

Section: таблица 2 содержание Tnf-α ммр-9 и Timp-1 в конденсате выдых...unclassified

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Molecular cellular reactions of the respiratory tract to cold stimulus in non-allergic bronchial asthma

Pirogov,

Prikhodko,

Pirogova

et al. 2024

Bûlletenʹ fiziologii i patologii dyhaniâ

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Influence of Secretome of Different Functional Phenotypes of Macrophages on Proliferation, Differentiation, and Collagen-Producing Activity of Dermal Fibroblasts In Vitro

et al. 2021

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Management of patients with the atrophic variant of vulvar lichen sclerosus

et al. 2022

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Aim.The objective is to optimize the diagnosis and management of the atrophic variant of the vulvar lichen sclerosus (LS). Materials and methods. We examined 58 female patients from 20 to 70 years old with the atrophic variant of the vulvar LS. The control group included 30 deemed healthy females 2070 years old. The atrophic variant of LS was diagnosed based on symptoms (dryness and discomfort in the vulva, superficial vulvodynia and dyspareunia, mild itching) and signs (marked atrophy of the external genitalia tissue up to aplasia of the labia minora and clitoris, vaginal stenosis, minimal hypopigmentation, absence of sclerosis). In addition, the following cytokines were measured in the peripheral blood of patients: interleukin (IL)-20, 23, 10, tumor necrosis factor-, and interferon-. The measurements were performed before and after immunotherapy with sodium deoxyribonucleate. Results. In all patients, there was a rapid shrinkage of the labia minora and clitoris, thinning and easy traumatization of the dermis and epidermis, contributing to secondary infection and synechiae formation up to complete vaginal occlusion. An increase in IL-23 (19.01 [18.0; 38.5] vs. 16.6 [12.98; 20.71] in the control group), 2.7-fold (p0.03) decrease in tumor necrosis factor-, interferon- and IL-20 are common for the atrophic variant of LS. The immunomodulatory and clinical efficacy of sodium deoxyribonucleate was demonstrated. Severe vulvodynia before treatment was noted in 29 (50%) patients and no patient (0%) after therapy; 44 (75.8%) patients reported complete reversal of superficial vulvodynia after treatment, and there were no patients without vulvodynia before treatment (0%). Mild itching before treatment was noted by 20 (40%) patients and 2 (3.4%) patients after treatment. Considering the cytokine levels, topical glucocorticoids in atrophic LS are inappropriate and can lead to atrophy and immunosuppression aggravation, contributing to the secondary infection. Conclusion. The observed differences in cytokine levels in patients with atrophic vulvar LS confirm the relevance of LS clinical classification by variants, support their use for LS diagnosis and immunotherapy efficacy control, and also suggest a differentiated approach to the treatment of different LS variants considering the effect of the drugs used on cytokine status.

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Production of factors involved into fibrosis regulation by various types of human macrophages

Cited by 3 publications

References 35 publications

Molecular cellular reactions of the respiratory tract to cold stimulus in non-allergic bronchial asthma

Molecular cellular reactions of the respiratory tract to cold stimulus in non-allergic bronchial asthma

Influence of Secretome of Different Functional Phenotypes of Macrophages on Proliferation, Differentiation, and Collagen-Producing Activity of Dermal Fibroblasts In Vitro

Management of patients with the atrophic variant of vulvar lichen sclerosus

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