Production of Equine Rabies Immune Globulin of High Purity, Potency, and Safety

Khomvilai, Sumana; Daviratanasilpa, Svastijaya; Pornmuttakun, Duangporn; Sakolpap, Lalida; Akesowan, Surasak; Pakmanee, Naruemol; Hemmala, Wachiraporn; Limsuwun, Kornvika; Tantavichien, Thanpet; Khawplod, Pakamatz

doi:10.1016/b978-0-12-801919-1.00024-5

Cited by 4 publications

(4 citation statements)

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“…We hereby reported the first two adult twins in Thailand who were simultaneously diagnosed with serum sickness after having received ERIG for the first time in their life - in spite of utilizing the ERIG brand with the low-protein content, i.e., 1 mg/mL [11]. To date, many conditions - including age, dose, and heterologous protein - were claimed as risk factors for serum sickness syndrome [12, 13]; nonetheless, being a twin sharing the same genotype has yet been postulated as a risk factor.…”

Section: Discussionmentioning

confidence: 99%

Serum Sickness after Equine Rabies Immunoglobulin in Identical Male Twins: Two Case Reports

Tawanwongsri

Wattanakrai

2019

Case Rep Dermatol

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We, hereby, report two cases of serum sickness in adult male identical twins who had received equine rabies immunoglobulin as a postexposure rabies treatment after cat scratches. The younger brother developed low-grade fever, polyarthritis, and multiple erythematous maculopapular eruptions, whereas low-grade fever and urticaria-like eruptions were detected in the elder brother. Both patients received a 7-day course of low-dose prednisolone and achieved good responses without recurrent attacks.

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Section: Discussionmentioning

confidence: 99%

Serum Sickness after Equine Rabies Immunoglobulin in Identical Male Twins: Two Case Reports

Tawanwongsri

Wattanakrai

2019

Case Rep Dermatol

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“…Compared with the popular equine-derived antivenom reported previously 17 , 18 , 19 , 20 , these studies showed that the RBSAV had relatively low toxicity and no adverse effects. Antivenom is the mainstay of treatment for snakebite envenoming, and adverse reactions to the available snake antivenom are common in many parts of the world where snakebites are prevalent.…”

Section: Discussionmentioning

confidence: 75%

“…There are very few published documents about the manufacturing process of this RBSAV. The World Health Organization (WHO) and other researchers have reported various methods for developing snake antivenoms through horse immunization, but no consensus has yet been reached 17 , 18 , 19 , 20 . Only very limited information is available describing the immunization of mammals with spider venom, and relevant information on RBS venom was found only in a single report by Wiener et al from 1961 7 .…”

Section: Discussionmentioning

confidence: 99%

Freeze-dried equine-derived redback spider antivenom: a local irritation study by intramuscular injection in rabbits and a repeated-dose toxicity study in rats

et al. 2018

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The redback spider (Latrodectus hasseltii) is nonindigenous to Japan but has now spread throughout the country. Bites to humans are rare but can be fatal. We prepared freeze-dried redback spider antivenom for therapeutic use against bites in Japan by immunization of horse plasma. This study included two nonclinical tests of the antivenom: a local irritation study involving a single intramuscular administration to rabbits (with injections of physiological saline and an existing freeze-dried diphtheria antitoxin as control and comparison substances, respectively) and a 2-week repeated intermittent intravenous-dose toxicity study in rats. The irritation study showed the antivenom’s irritancy to be comparable with that of the saline and the existing antitoxin preparations under the test conditions. In a repeated-dose toxicity study, no toxicity change was found in male or female rats, and the no-observed-adverse-effect level (NOAEL) was judged to be a dose volume of 20 mL/kg (1082 units/kg antivenom activity) in both male and female rats. In addition, there was no toxicological difference between proteinaceous diphtheria antitoxin and redback spider antivenom prepared to have the same protein content and the same additive composition. Based on these findings, we will further advance our research towards clinical application of the redback spider antivenom. This research was supported by the Research Program on Emerging and Re-emerging Infectious Disease of the Japan Agency for Medical Research and Development.

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“… 15 – 17 During the 1970s, the introduction of tissue culture vaccines created a gold standard for human rabies post-exposure prophylaxis, as we describe in the data repository. 18 For many years, the five-dose, Thai Red Cross intradermal regimen was the preferred option for high-throughput clinics in low- and middle-income countries where rabies is endemic, 19 , 20 whereas the intramuscular Essen regimen was prescribed in developed countries with few patients. Intradermal administration of rabies vaccine allowed smaller doses to be given without compromising efficacy or safety.…”

Section: Introductionmentioning

confidence: 99%