Production of Cordyceps militaris metabolites in infected wax moth Galleria mellonella L. larvae

Tyurin, M. V.; Orlova, T. I.; Tomilova, Oksana G.; Saveleva, E. I.; Kryukov, V. Yu.; Berestetskiy, Alexander

doi:10.15298/euroasentj.17.5.11

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…At the same time, it was non-toxic when applied topically [ 78 ]. Cordycepin was detected in artificially infected G. mellonella larvae to be an inhibitor of their immune response (e.g., the expression of protective genes) contributing to the disease development [ 79 , 80 ].…”

Section: Low-molecular-weight Non-volatile Compoundsmentioning

confidence: 99%

The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management

Berestetskiy

2021

Microorganisms

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Biorational insecticides (for instance, avermectins, spinosins, azadirachtin, and afidopyropen) of natural origin are increasingly being used in agriculture. The review considers the chemical ecology approach for the search for new compounds with insecticidal properties (entomotoxic, antifeedant, and hormonal) produced by fungi of various ecological groups (entomopathogens, soil saprotrophs, endophytes, phytopathogens, and mushrooms). The literature survey revealed that insecticidal metabolites of entomopathogenic fungi have not been sufficiently studied, and most of the well-characterized compounds show moderate insecticidal activity. The greatest number of substances with insecticidal properties was found to be produced by soil fungi, mainly from the genera Aspergillus and Penicillium. Metabolites with insecticidal and antifeedant properties were also found in endophytic and phytopathogenic fungi. It was noted that insect pests of stored products are mostly low sensitive to mycotoxins. Mushrooms were found to be promising producers of antifeedant compounds as well as insecticidal proteins. The expansion of the number of substances with insecticidal properties detected in prospective fungal species is possible by mining fungal genomes for secondary metabolite gene clusters and secreted proteins with their subsequent activation by various methods. The efficacy of these studies can be increased with high-throughput techniques of extraction of fungal metabolites and their analysis by various methods of chromatography and mass spectrometry.

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Section: Low-molecular-weight Non-volatile Compoundsmentioning

confidence: 99%

The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management

Berestetskiy

2021

Microorganisms

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Promising approaches to the search for fungal metabolites for management of arthropod pests

Берестецкий¹,

Lednev²,

Ху

2021

1727-1320

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Biorational insecticides of natural origin, such as avermectins, spinosins, azadirachtin and afidopyropen, are increasingly used in agriculture. The present paper reviews modern ecological, genomic, and biotechnological approaches to the search for new compounds with insecticidal properties (entomotoxic, antifeedant, and hormonal) produced by fungi of various ecological groups (entomopathogens, soil saprotrophs, endophytes, phytopathogens, and mushrooms). The literature survey showed that insecticidal metabolites of entomopathogenic fungi had not been sufficiently studied, and the majority of well-characterized compounds had showed moderate insecticidal activity. The greatest number of substances with insecticidal properties was found to be produced by soil fungi, mainly from the genera Aspergillus and Penicillium. Metabolites with insecticidal and antifeedant properties were also found in endophytic and phytopathogenic fungi. Low sensitivity of insect pests of stored products (in particular, of grain) to mycotoxins was recorded. Mushrooms were found to be promising producers of antifeedant compounds as well as insecticidal proteins. It is possible to increase the number of substances with insecticidal properties detected in fungi not only by extension of the screening range but also by exploitation of diverse bioassay sytems and model insect species. Mining genomes for secondary metabolite gene clusters and secreted proteins with their subsequent activation by various methods allows for better understanding of the biosynthetic potential of the prospective strains. Efficacy of these studies can be increased with high-throughput techniques of fungal metabolites extraction and further analysis using chromatography and mass spectrometry. Insecticidal proteins detected in fungi can be used in the technologies for development of transgenic plant varieties resistant to pests, or hypervirulent bioinsecticides.

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Production of Cordyceps militaris metabolites in infected wax moth Galleria mellonella L. larvae

Cited by 2 publications

References 13 publications

The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management

The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management

Promising approaches to the search for fungal metabolites for management of arthropod pests

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