Production of Colony-Stimulating Factor by Human Macrophages

Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia

“…6 Hematopoietic cells as well as stromal cells have been reported to express a wide range of substances which may play complex regulatory roles in hematopoiesis. [7][8][9] We have reported previously that the number of macrophage lineage cells significantly increased in the bone marrow of MDS patients as compared with that of the control or de novo AML bone marrow. 10 Furthermore, bone marrow macrophages express tumor necrosis factor (TNF)␣ and interferon (IFN)-␥ which have an accelerating effect on apoptosis.…”

Overexpression of tumor necrosis factor (TNF)-α and interferon (IFN)-γ by bone marrow cells from patients with myelodysplastic syndromes

“…18 Hematopoietic cells as well as stromal cells have been reported to express a wide range of substances which may play complex regulatory roles in hematopoiesis. [19][20][21] We have reported previously that the number of macrophage-lineage cells significantly increased in the bone marrow of MDS patients as compared with that of the control or de novo AML bone marrow. 22 Therefore not only the proliferation of MDS clone cells but also the abnormal function of stromal cells of the bone marrow may be involved in mechanisms causing cytopenias in MDS through disturbed regulation of the expression and production of growth factors and cytokines.…”

In vitro Colony Forming Cells and Colony Stimulating Factor in Chronic Granulocytic Leukaemia

“…It has been estimated that the normal individual has about 10 CFC per 106 nucleated cells in the peripheral blood (Chervenick and Boggs, 1971) (Moore et al, 1973b Golde, Finley and Cline, 1972;Chervenick and LoBuglio, 1972 The finding that the peripheral blood of untreated patients with CGL does not provide CSF could be explained in a number of ways. In the first place it is possible that CSF is produced but consumed locally by CFC and cluster forming cells present in the feeder layer.…”