Production of Citric, Itaconic, Fumaric, and Malic Acids in Filamentous Fungal Fermentations

Zhang, Kun; Zhang, Baohua; Yang, Shang‐Tian

doi:10.1002/9781118642047.ch20

Cited by 22 publications

(15 citation statements)

References 115 publications

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“…Compared to these recent studies, we achieved high fumaric acid production with a product titer of 50.2 g/L and yield of 0.72 g/g in shake-flask fermentation with 90 g/L of glucose in the fermentation medium. Both the product titer and yield could be further improved with a higher glucose concentration since a high C/N ratio of 120-250 (w/w) is favorable for fumaric acid production [1]. SMH also gave superior results compared to urea as the nitrogen source for the fermentation carried out in 5-L STR, although the fermentation performance in STR was not as good as that in shake-flasks and would require further optimization.…”

Section: Comparison To Other Studiesmentioning

confidence: 96%

“…Fumaric acid, an organic acid with a trans-double bond and two carboxylic acid groups, is an important specialty chemical with wide industrial applications, including uses as food acidulants and in the synthesis of polymeric resins [1,2]. Fumaric acid can be readily transformed into other C4 chemicals including malic acid, succinic acid and aspartic acid [3], and has been identified by the U.S. Department of Energy as one of the "top 12" buildingblock chemicals that can be produced from renewable biomass [4].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, fumaric acid is mainly produced via petroleum-based chemical synthesis. However, limited petroleum resources, rising oil prices, and concerns of environmental pollution caused by chemical synthesis have prompted renewed interests in fumaric acid production from sugars by fermentation using filamentous fungi, Rhizopus oryzae and Rhizopus arrhizus [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of soybean meal hydrolysate as the nitrogen source on seed culture morphology and fumaric acid production by Rhizopus oryzae

Zhang¹,

Chen²,

Yang³

2015

Process Biochemistry

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Section: Comparison To Other Studiesmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of soybean meal hydrolysate as the nitrogen source on seed culture morphology and fumaric acid production by Rhizopus oryzae

Zhang¹,

Chen²,

Yang³

2015

Process Biochemistry

Self Cite

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“…Its main applications include food, beverages, pharmaceuticals, detergents, buffering and chelating agents. 159 It is used as a multifunctional monomer to react with different aliphatic diols to give biodegradable polyester elastomers. Tran et al reviewed various other citric acid based elastomers, including crosslinked urethane-doped polyesters (CUPEs), poly (alkylene maleate citrates) (PAMCs), poly (xylitol-cocitrate) (PXC) and poly(poly(ethylene glycol) maleate citrate) (PPEGMC).…”

Section: Other Lignocellulosic Biomass Derivable Polymersmentioning

confidence: 99%

Lignocellulosic biomass: a sustainable platform for the production of bio-based chemicals and polymers

2015

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The demand for petroleum dependent chemicals and materials has been increasing despite the dwindling of their fossil resources. As the dead-end of petroleum based industry has started to appear, today's modern society has to implement alternative energy and valuable chemical resources immediately. Owing to the importance of lignocellulosic biomass for being the most abundant and bio-renewable biomass on earth, this critical review provides insights into the potential of lignocellulosic biomass as an alternative platform to fossil resources. In this context, over 200 value-added compounds, which can be derived from lignocellulosic biomass by using various treatment methods, are presented with their references. Lignocellulosic biomass based polymers and their commercial importance are also reported mainly in the frame of these compounds. The review article aims to draw the map of lignocellulosic biomass derived chemicals and their synthetic polymers, and to reveal the scope of this map in today's modern chemical and polymer industry.

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“…The global fumaric acid market demand was estimated as 225.2 kt in 2012 and it is expected to be over 300 kt in 2020 [2]. The production of fumaric acid is based on the isomerization of maleic acid derived originally from n-butene [3]. The petrochemical method has the advantage of high production yields, compared with the biotechnological production through…”

Section: Introductionmentioning

confidence: 99%

Biotechnological Production of Fumaric Acid: The Effect of Morphology of Rhizopus arrhizus NRRL 2582

et al. 2017

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Fumaric acid is a platform chemical with many applications in bio-based chemical and polymer production. Fungal cell morphology is an important factor that affects fumaric acid production via fermentation. In the present study, pellet and dispersed mycelia morphology of Rhizopus arrhizus NRRL 2582 was analysed using image analysis software and the impact on fumaric acid production was evaluated. Batch experiments were carried out in shake flasks using glucose as carbon source. The highest fumaric acid yield of 0.84 g/g total sugars was achieved in the case of dispersed mycelia with a final fumaric acid concentration of 19.7 g/L. The fumaric acid production was also evaluated using a nutrient rich feedstock obtained from soybean cake, as substitute of the commercial nitrogen sources. Solid state fermentation was performed in order to produce proteolytic enzymes, which were utilised for soybean cake hydrolysis. Batch fermentations were conducted using 50 g/L glucose and soybean cake hydrolysate achieving up to 33 g/L fumaric acid concentration. To the best of our knowledge the influence of R. arrhizus morphology on fumaric acid production has not been reported previously. The results indicated that dispersed clumps were more effective in fumaric acid production than pellets and renewable resources could be alternatively valorised for the biotechnological production of platform chemicals.

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Production of Citric, Itaconic, Fumaric, and Malic Acids in Filamentous Fungal Fermentations

Cited by 22 publications

References 115 publications

Effects of soybean meal hydrolysate as the nitrogen source on seed culture morphology and fumaric acid production by Rhizopus oryzae

Effects of soybean meal hydrolysate as the nitrogen source on seed culture morphology and fumaric acid production by Rhizopus oryzae

Lignocellulosic biomass: a sustainable platform for the production of bio-based chemicals and polymers

Biotechnological Production of Fumaric Acid: The Effect of Morphology of Rhizopus arrhizus NRRL 2582

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