Production of carotenoids by microalgae: achievements and challenges

Varela, João; Pereira, Hugo; Vilà, Marta; Léon, Rosa

doi:10.1007/s11120-015-0149-2

Cited by 186 publications

(90 citation statements)

References 150 publications

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“…As the most diverse and widespread pigments in the chloroplast, carotenoids, including carotene and lutein, are indispensable in light harvesting and energy transfer during photosynthesis and in the protection of the photosynthetic apparatus against photooxidative damage (Varela et al, 2015). Dunaliella have an ability to accumulate carotenoids, especially β-carotene located within the chloroplast, under unfavourable conditions (salinity or nutritional deficiency).…”

Section: Discussionmentioning

confidence: 99%

Transcriptome sequencing and annotation of the halophytic microalga Dunaliella salina

Midoun

Miller

2017

J. Zhejiang Univ. Sci. B

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Abstract:The unicellular green alga Dunaliella salina is well adapted to salt stress and contains compounds (including β-carotene and vitamins) with potential commercial value. A large transcriptome database of D. salina during the adjustment, exponential and stationary growth phases was generated using a high throughput sequencing platform. We characterized the metabolic processes in D. salina with a focus on valuable metabolites, with the aim of manipulating D. salina to achieve greater economic value in large-scale production through a bioengineering strategy. Gene expression profiles under salt stress verified using quantitative polymerase chain reaction (qPCR) implied that salt can regulate the expression of key genes. This study generated a substantial fraction of D. salina transcriptional sequences for the entire growth cycle, providing a basis for the discovery of novel genes. This first full-scale transcriptome study of D. salina establishes a foundation for further comparative genomic studies.

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Section: Discussionmentioning

confidence: 99%

Transcriptome sequencing and annotation of the halophytic microalga Dunaliella salina

Midoun

Miller

2017

J. Zhejiang Univ. Sci. B

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“…Carotenoids are lipophilic compounds appearing in different colors such as yellow, orange, and red. They are the most prevalent and frequent pigments found in nature [186,187] with more than 700 of them identified to this day [38,56]. Most carotenoids have a mutual C40 isoprene unit backbone structure, called terpenoid, and are categorized into two groups: carotenes and xanthophylls.…”

Section: Carotenoidsmentioning

confidence: 99%

Marine Bacteria versus Microalgae: Who Is the Best for Biotechnological Production of Bioactive Compounds with Antioxidant Properties and Other Biological Applications?

Hamidi

Kozani

et al. 2019

Marine Drugs

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Natural bioactive compounds with antioxidant activity play remarkable roles in the prevention of reactive oxygen species (ROS) formation. ROS, which are formed by different pathways, have various pathological influences such as DNA damage, carcinogenesis, and cellular degeneration. Incremental demands have prompted the search for newer and alternative resources of natural bioactive compounds with antioxidant properties. The marine environment encompasses almost three-quarters of our planet and is home to many eukaryotic and prokaryotic microorganisms. Because of extreme physical and chemical conditions, the marine environment is a rich source of chemical and biological diversity, and marine microorganisms have high potential as a source of commercially interesting compounds with various pharmaceutical, nutraceutical, and cosmeceutical applications. Bacteria and microalgae are the most important producers of valuable molecules including antioxidant enzymes (such as superoxide dismutase and catalase) and antioxidant substances (such as carotenoids, exopolysaccharides, and bioactive peptides) with various valuable biological properties and applications. Here, we review the current knowledge of these bioactive compounds while highlighting their antioxidant properties, production yield, health-related benefits, and potential applications in various biological and industrial fields.

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“…Since lipids are produced in the thylakoid membrane, this may be a physical phenomenon with a trade-off between the volume of lipid droplets produced, the number of reaction centers, and the volume of chloroplasts. Interestingly, neutral lipid globules in stressed microalgae sequester beta carotene and are thought to act as a sunscreen layer [57]. Since lipid bodies are pervasive in many species of microalgae, a high lipid concentration may be an adaptation to light stress.…”

Section: Pigments Neutral Lipids and Cell Sizementioning

confidence: 99%

The influence of bio-optical properties of Emiliania huxleyi and Tetraselmis sp. on biomass and lipid production when exposed to different light spectra and intensities of an adjustable LED array and standard light sources

et al. 2019

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The effects of bio-optical characteristics on lipid and biomass production rates for Emiliania huxleyi and Tetraselmis sp. were studied under different irradiances and spectra. Biomass and lipid production increased from irradiances of 50-800 μE m −2 s −1 but differed for each spectrum. The highest biomass and neutral lipid production rates for E. huxleyi occurred under a red-blue LED array, which mimicked the absorption spectra of the cell's chlorophyll a and accessory pigments, especially fucoxanthins. Biomass and neutral lipid production for Tetraselmis sp. were enhanced under broader spectra of cool white and grow lights. Neutral lipids per cell volume were similar for the two species and inversely proportional to chlorophyll a concentrations. High biomass and neutral lipid production rates were associated with high total quantum absorption and low quantum absorption per cell. Generally, quantum efficiencies were highest for high light treatments with high total quantum absorption and high production rates. Using reconstructed quantum absorption by pigments, the bio-optical model showed that photoprotective pigments were dependent on light intensity and spectra. Quantum efficiencies increased when excluding the contribution of photoprotective pigments to total quantum absorption since they did not directly contribute to photosynthesis, but did promote higher production rates.

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Production of carotenoids by microalgae: achievements and challenges

Cited by 186 publications

References 150 publications

Transcriptome sequencing and annotation of the halophytic microalga Dunaliella salina

Transcriptome sequencing and annotation of the halophytic microalga Dunaliella salina

Marine Bacteria versus Microalgae: Who Is the Best for Biotechnological Production of Bioactive Compounds with Antioxidant Properties and Other Biological Applications?

The influence of bio-optical properties of Emiliania huxleyi and Tetraselmis sp. on biomass and lipid production when exposed to different light spectra and intensities of an adjustable LED array and standard light sources

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