2002
DOI: 10.1128/jcm.40.4.1546-1548.2002
|View full text |Cite
|
Sign up to set email alerts
|

Production of BRO β-Lactamases and Resistance to Complement in European Moraxella catarrhalis Isolates

Abstract: Of the 419 Moraxella catarrhalis isolates collected during the 1997-1999 European SENTRY surveillance study, 385 (92%) were ␤-lactamase positive. Twenty-two (5.7%) produced BRO-2 ␤-lactamase. Twenty-one new mutations were found in the putative promoter region of the bro genes. Nineteen percent of all isolates tested were complement sensitive. Resistance to ␤-lactams is not linked to the phylogenetic lineages associated with susceptibility to complement.Moraxella catarrhalis was long considered a harmless comme… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
17
0
1

Year Published

2005
2005
2017
2017

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 36 publications
(19 citation statements)
references
References 29 publications
0
17
0
1
Order By: Relevance
“…The fact that some strains of M. catarrhalis can resist serum killing was first described some 20 years ago by Winn and Morse (reviewed in references 10 and 50), and several recent studies indicate that the vast majority of M. catarrhalis isolates are resistant to serum killing (13,34,45). The identity of the gene product(s) responsible for this phenotype has been the subject of much research interest over the past decade, and it was first suggested by Verduin et al (54) that a proteinaceous substance on the surface of M. catarrhalis was responsible for complement resistance.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The fact that some strains of M. catarrhalis can resist serum killing was first described some 20 years ago by Winn and Morse (reviewed in references 10 and 50), and several recent studies indicate that the vast majority of M. catarrhalis isolates are resistant to serum killing (13,34,45). The identity of the gene product(s) responsible for this phenotype has been the subject of much research interest over the past decade, and it was first suggested by Verduin et al (54) that a proteinaceous substance on the surface of M. catarrhalis was responsible for complement resistance.…”
Section: Discussionmentioning
confidence: 99%
“…First observed about 20 years ago (reviewed in references 10 and 50), the occurrence of the serum-resistant phenotype has been documented in many subsequent studies of M. catarrhalis isolates (10,13,25,34,45,50,59). The hypothesis that serum resistance might be a virulence factor for M. catarrhalis stemmed from observations that the incidence of complement-resistant M. catarrhalis strains was higher in samples isolated from ill patients (i.e., adults with lower respiratory tract infections) than in samples from healthy adults or children (20,25).…”
mentioning
confidence: 99%
“…M. catarrhalis is known to be resistant to penicillin and first-generation cephalosporins, owing to its ability to produce BRO ␤-lactamase; however, it typically remains susceptible to other antibiotics, including fluoroquinolones (2)(3)(4). Fluoroquinolones act primarily by inhibiting DNA gyrase and topoisomerase IV.…”
mentioning
confidence: 99%
“…catarrhalis infections are a matter of concern due to high carriage rates in children, the lack of a preventative vaccine, and the rapid emergence of antibiotic resistance in clinical isolates. Virtually all M. catarrhalis strains are resistant to ␤-lactams (34,47,48,50,53,65,81,84). The genes specifying this resistance appear to be gram positive in origin (14, 15), suggesting that the organism could acquire genes conferring resistance to other antibiotics via horizontal transfer.…”
mentioning
confidence: 99%