Production of Bi-Compartmental Tablets by FDM 3D Printing for the Withdrawal of Diazepam

Macedo, Joana; Marques, Rita; Vervaet, Chris; Pinto, João F.

doi:10.3390/pharmaceutics15020538

Cited by 9 publications

(4 citation statements)

References 32 publications

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“…As the extrusion was carried out at a significantly lower temperature than the melting point of 5-ASA (180 • C vs. 270 • C), crystalline drug domains remained within the filament. The negative impact of drug incorporation on the surface smoothness of filaments obtained from Parteck ® MXP PVA has also been described by other authors [19,54].…”

Section: Scanning Electron Microscopy (Sem)supporting

confidence: 69%

“…Thus, even more sophisticated dosage forms able to control drug release can be developed [ 15 , 16 , 17 ]. Different studies have been reported in the literature dealing with the application of the dual-nozzle FDM technique to fabricate multicompartment drug delivery systems, mostly in the form of bi- or multilayer [ 14 , 15 , 17 , 18 , 19 , 20 , 21 ] and shell-core [ 9 , 16 , 17 , 18 , 22 , 23 ] designs. The combination of hybrid formulations and/or structurally different sections into the same dosage form opens new opportunities to achieve customized drug release profiles [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Development of 3D-Printed Bicompartmental Devices by Dual-Nozzle Fused Deposition Modeling (FDM) for Colon-Specific Drug Delivery

Shojaie,

Ferrero,

Caraballo

2023

Pharmaceutics

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Dual-nozzle fused deposition modeling (FDM) is a 3D printing technique that allows for the simultaneous printing of two polymeric filaments and the design of complex geometries. Hence, hybrid formulations and structurally different sections can be combined into the same dosage form to achieve customized drug release kinetics. The objective of this study was to develop a novel bicompartmental device by dual-nozzle FDM for colon-specific drug delivery. Hydroxypropylmethylcellulose acetate succinate (HPMCAS) and polyvinyl alcohol (PVA) were selected as matrix-forming polymers of the outer pH-dependent and the inner water-soluble compartments, respectively. 5-Aminosalicylic acid (5-ASA) was selected as the model drug. Drug-free HPMCAS and drug-loaded PVA filaments suitable for FDM were extruded, and their properties were assessed by thermal, X-ray diffraction, microscopy, and texture analysis techniques. 5-ASA (20% w/w) remained mostly crystalline in the PVA matrix. Filaments were successfully printed into bicompartmental devices combining an outer cylindrical compartment and an inner spiral-shaped compartment that communicates with the external media through an opening. Scanning electron microscopy and X-ray tomography analysis were performed to guarantee the quality of the 3D-printed devices. In vitro drug release tests demonstrated a pH-responsive biphasic release pattern: a slow and sustained release period (pH values of 1.2 and 6.8) controlled by drug diffusion followed by a faster drug release phase (pH 7.4) governed by polymer relaxation/erosion. Overall, this research demonstrates the feasibility of the dual-nozzle FDM technique to obtain an innovative 3D-printed bicompartmental device for targeting 5-ASA to the colon.

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Section: Scanning Electron Microscopy (Sem)supporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Development of 3D-Printed Bicompartmental Devices by Dual-Nozzle Fused Deposition Modeling (FDM) for Colon-Specific Drug Delivery

Shojaie,

Ferrero,

Caraballo

2023

Pharmaceutics

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“…Contemporary 3D printing technologies provide a versatile platform for preparing highly innovative personalized pharmaceutical dosage forms [26]. Moreover, 3D printing is a valuable technique especially for poorly water-soluble drugs, such as benzodiazepine derivatives, to overcome the challenges related to their formulation, and to enhance their oral bioavailability and therapeutic efficacy [39,40]. Pharmaceutical SSE 3D printing enables also to combine two or more active agents in the same final DDSs without the risk of physicochemical incompatibility between such compounds.…”

Section: Discussionmentioning

confidence: 99%

Semi-solid extrusion 3D printing of functionalized polyethylene oxide gels loaded with 1,2,3-triazolo-1,4-benzodiazepine nanofibers and valine-modified motherwort (Leonurus cardiaca L.) dry extract

Botsula,

Kireyev,

Koshovyi

et al. 2024

SR: PS

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Anxiety disorders are the most prevalent psychiatric disorders and are associated with a high burden of illness. Combining synthetic and native-origin compounds in treating such disorders could provide true benefits in terms of therapeutic efficacy. In the present study, we combined triazolobenzodiazepine and motherwort (Leonurus cardiaca L.) dry extract for such applications. The aim. The aim of this study was to develop aqueous polyethylene oxide (PEO) composite gels loaded with 1,2,3-triazolo-1,4-benzodiazepine nanofibers and a valine-modified motherwort herb dry extract for semi-solid extrusion (SSE) 3D printing. The printability of such gels and the physicochemical properties of the final 3D-printed drug preparations were investigated. Materials and methods. A new drug substance, 1,2,3-triazolo-1,4-benzodiazepine (MA-253) was synthesized and used to formulate oleogels and electrospun nanofibers for 3D printing. The plant-origin dry extract was prepared from a motherwort tincture and valine. The aqueous PEO gels loaded with a synthetic drug (MA-253) containing nanofibers and a valine-modified motherwort extract were prepared and subsequently used in the SSE 3D printing experiments. The homogeneity, viscosity and 3D printability of composite PEO gels were verified. The phytochemical assay of flavonoids in the 3D-printed drug preparations was conducted with the European pharmacopoeia spectrophotometric method. Research results. Three experimental gel formulations loaded with 1,2,3-triazolo-1,4-benzodiazepine nanofibers and a valine-modified motherwort dry extract were developed and tested for the SSE 3D printing applications. The present three gels showed good SSE 3D printability without any significant printing flaws. The SSE 3D-printed lattices prepared from the aqueous PEO gels containing 100 mg/ml of motherwort extract showed the most promising 3D printing performance. The 3D-printed drug preparations were entirely dissolved in purified water (22±2 °C) within 20 minutes, thus suggesting their applicability in oral administration. Conclusions. Novel aqueous PEO gel formulations loaded with nanofibrous 1,2,3-triazolo-1,4-benzodiazepine nanofibers and valine-modified motherwort herb extract are feasible for pharmaceutical SSE 3D printing. The present composite PEO gels enable the preparation of printed oral immediate-release drug delivery systems for new triazolobenzodiazepine derivatives and a drug therapy supportive plant extract

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“…The 3D printing technique results in the development of drug products with varied geometries and modified drug release characteristics, focusing on customized delivery of drug products [ 13 , 14 ]. The various types of 3D printing techniques that have been extensively used in the pharmaceutical field include deposition-based inkjet printing [ 15 , 16 ], powder bed deposition [ 17 , 18 ], extrusion-based fused deposition modeling (FDM) [ 19 , 20 ], pressure-assisted microsyringe (PAM) technique [ 21 , 22 ], laser-based selective laser sintering (SLS) [ 23 ], and stereolithography (SLA) techniques [ 24 ]. The application of nanotechnology in drug delivery has the potential to improve the biopharmaceutical attributes (improving the solubility and permeability) of drugs, enhance therapeutic efficacy, and reduce the side effects of APIs (active pharmaceutical ingredients).…”

Section: Introductionmentioning

confidence: 99%

3D Printing Technology as a Promising Tool to Design Nanomedicine-Based Solid Dosage Forms: Contemporary Research and Future Scope

et al. 2023

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3D printing technology in medicine is gaining great attention from researchers since the FDA approved the first 3D-printed tablet (Spritam®) on the market. This technique permits the fabrication of various types of dosage forms with different geometries and designs. Its feasibility in the design of different types of pharmaceutical dosage forms is very promising for making quick prototypes because it is flexible and does not require expensive equipment or molds. However, the development of multi-functional drug delivery systems, specifically as solid dosage forms loaded with nanopharmaceuticals, has received attention in recent years, although it is challenging for formulators to convert them into a successful solid dosage form. The combination of nanotechnology with the 3D printing technique in the field of medicine has provided a platform to overcome the challenges associated with the fabrication of nanomedicine-based solid dosage forms. Therefore, the major focus of the present manuscript is to review the recent research developments that involved the formulation design of nanomedicine-based solid dosage forms utilizing 3D printing technology. Utilization of 3D printing techniques in the field of nanopharmaceuticals achieved the successful transformation of liquid polymeric nanocapsules and liquid self-nanoemulsifying drug delivery systems (SNEDDS) to solid dosage forms such as tablets and suppositories easily with customized doses as per the needs of the individual patient (personalized medicine). Furthermore, the present review also highlights the utility of extrusion-based 3D printing techniques (Pressure-Assisted Microsyringe—PAM; Fused Deposition Modeling—FDM) to produce tablets and suppositories containing polymeric nanocapsule systems and SNEDDS for oral and rectal administration. The manuscript critically analyzes contemporary research related to the impact of various process parameters on the performance of 3D-printed solid dosage forms.

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Production of Bi-Compartmental Tablets by FDM 3D Printing for the Withdrawal of Diazepam

Cited by 9 publications

References 32 publications

Development of 3D-Printed Bicompartmental Devices by Dual-Nozzle Fused Deposition Modeling (FDM) for Colon-Specific Drug Delivery

Development of 3D-Printed Bicompartmental Devices by Dual-Nozzle Fused Deposition Modeling (FDM) for Colon-Specific Drug Delivery

Semi-solid extrusion 3D printing of functionalized polyethylene oxide gels loaded with 1,2,3-triazolo-1,4-benzodiazepine nanofibers and valine-modified motherwort (Leonurus cardiaca L.) dry extract

3D Printing Technology as a Promising Tool to Design Nanomedicine-Based Solid Dosage Forms: Contemporary Research and Future Scope

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