Production of antibody to hepatitis A virus and hepatitis B surface antigen measured after combined hepatitis A/ hepatitis B vaccination in 242 adult volunteers

Reutter, J.; Bart, Pierre Alexandre; Francioli, P.; Safary, Assad; Frei, P.C.

doi:10.1046/j.1365-2893.1998.00101.x

Cited by 21 publications

(7 citation statements)

References 22 publications

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“…Additional studies with mice have documented gender-dependent differences in response to keyhole limpet hemocyanin (67), OVA (67), hen egg lysozyme (20), and polyvinyl pyrrolidone (13), with female mice mounting more potent antigen-specific immune responses than males. Similar gender-dependent differences in vaccinated swine and humans have been reported (3,8,48). Importantly, an HSV experimental vaccine was protective in human females but not in males (60), and a pseudorabies virus vaccine resulted in significantly lower virus excretion in female swine than in male swine (8).…”

Section: Discussionsupporting

confidence: 62%

“…Because gender differences in response to vaccines have been reported, (3,8,13,20,48,64,67), we examined these three best immunization strategies, DNA prime-rMVA boost, peptide prime-rMVA boost and rMVA prime-rMVA boost for their ability to induce antigen-specific T-cell responses in spleens of both female and male BALB/c mice (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…First, the age of the vaccinee may affect the response. There were no differences in postimmunization vaccine-specific antibody titers between genders in infants vaccinated with acellular or whole-cell pertussis vaccines (6), while vaccination of adult females resulted in antigen-specific immune responses significantly greater than those induced in adult males (3,48,60). In contrast, with the inactivated influenza vaccine, there was no significant difference in vaccine-specific immune responses between adult men and women (2,6).…”

Section: Discussionmentioning

confidence: 99%

“…Gender has also been reported to affect immune responses after pseudorabies virus vaccination of swine (8). Vaccine-induced antibody responses were significantly greater in women than men (3,48), and a herpes simplex virus (HSV) vaccine was protective in females but not in males (60). Measurement of antigen-specific immune responses by enzyme-linked immunosorbent assay, neutralizing antibody, lymphocyte proliferation, and gamma interferon IFN-␥ secretion assays in the HSV vaccine trial did not reveal any differences in the magnitude of vaccine-induced immunity between males and females, although significant differences in efficacy were observed (60).…”

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confidence: 99%

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Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting

Peacock¹,

Nordone²,

Jackson

et al. 2004

J Virol

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Induction of mucosal anti-human immunodeficiency virus type 1 (HIV-1) T-cell responses in males andfemales will be important for the development of a successful HIV-1 vaccine. An HIV-1 envelope peptide, DNA plasmid, and recombinant modified vaccinia virus Ankara (rMVA) expressing the H-2D d -restricted cytotoxic T lymphocyte P18 epitope were used as immunogens to test for their ability to prime and boost anti-HIV-1 T-cell responses at mucosal and systemic sites in BALB/c mice. We found of all prime-boost combinations tested, an HIV-1 Env peptide subunit mucosal prime followed by systemic (intradermal) boosting with rMVA yielded the maximal induction of gamma interferon (IFN-␥) spot-forming cells in the female genital tract and colon. However, this mucosal prime-systemic rMVA boost regimen was minimally immunogenic for the induction of genital, colon, or lung anti-HIV-1 T-cell responses in male mice. We determined that a mucosal Env subunit immunization could optimally prime an rMVA boost in female but not male mice, as determined by the magnitude of antigen-specific IFN-␥ responses in the reproductive tracts, colon, and lung. Defective mucosal priming in male mice could not be overcome by multiple mucosal immunizations. However, rMVA priming followed by an rMVA boost was the optimal prime-boost strategy for male mice as determined by the magnitude of antigen-specific IFN-␥ responses in the reproductive tract and lung. Thus, prime-boost immunization strategies able to induce mucosal antigen-specific IFN-␥ responses were identified for male and female mice. Understanding the cellular and molecular basis of gender-determined immune responses will be important for optimizing induction of anti-HIV-1 mucosal immune responses in both males and females.

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Section: Discussionsupporting

confidence: 62%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting

Peacock¹,

Nordone²,

Jackson

et al. 2004

J Virol

View full text Add to dashboard Cite

show abstract

“…Subjects with no anti-HBs at this point, as measured by commercial enzyme-linked immunoassays (EIA), are said to be``nonresponders''. Their proportion of the population depends on various factors, including gender, age, body mass index, smoking habits and immunogenetic factors [12,14]. The risk for such subjects of becoming infected with HBV and/or of developing clinical hepatitis is not well de®ned.…”

Section: Introductionmentioning

confidence: 99%

Absence of anti-hepatitis B surface antibody after vaccination does not necessarily mean absence of immune response

Greub

Zysset

Genton

et al. 2001

Medical Microbiology and Immunology

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A small number of subjects vaccinated against hepatitis B do not produce anti-hepatitis B surface (HBs) antibody levels detectable by commercial assays. Others lose detectable anti-HBs at some time after vaccination. The absence of clinical hepatitis despite potential exposure to hepatitis B virus (HBV) in both kinds of subjects suggests that they might be protected by low antibody levels. However, besides anti-HBs, T helper response and memory cells which may be induced by the vaccine are certainly also important for immunity against HBV. In the present study, samples from vaccinated subjects, found to be anti-HBs negative in an initial assay, subsequently showed positive results in, respectively, 25%, 36% and 38% of the cases, when a second, third and fourth assay was used. In addition, 360 samples from "nonresponders" and from vaccinees who had lost anti-HBs, the reactivity of which was under the enzyme-linked immunoassay-cut-off value were compared to that of nonvaccinated controls. The absorbances were found to be significantly higher in the nonresponders (0.038) and in the vaccinees having lost anti-HBs (0.041), than in the controls (0.025). Such findings contribute to explaining why so-called nonresponders as well as vaccinees who have lost anti-HBs nevertheless appear to be protected.

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A two dose combined hepatitis A and B vaccine in Chinese youngsters

Lee

Chan

et al. 1999

J. Med. Virol.

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This open, randomized study was conducted in healthy Chinese youngsters, aged between 10 and 19 years to compare the reactogenicity and immunogenicity of two vaccines: the combined vaccine against hepatitis A and B was administered in a two-dose schedule with the profile of the corresponding monovalent vaccines, while the concomitant vaccine was administered also on a two-dose schedule but simultaneously in opposite arms. All vaccinees had antibodies against hepatitis A (anti-HAV) after the 2-dose administration, whereas all but four in the first and two in the second group had protective titres against hepatitis B (anti-HBs). At month 7, the geometric mean titres for both antibodies were more than double for the group of subjects receiving the combined vaccine: 3,701 vs. 1,705 mIU/ml for the anti-HAV, and 1,524 vs. 720 mIU/ ml for the anti-HBs response. Injection site pain was the most commonly reported local symptom and headache was the most reported general symptom. It is concluded that this combined vaccine against hepatitis A and B, administered according to a two-dose schedule, is well-tolerated and highly immunogenic.

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Production of antibody to hepatitis A virus and hepatitis B surface antigen measured after combined hepatitis A/ hepatitis B vaccination in 242 adult volunteers

Cited by 21 publications

References 22 publications

Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting

Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting

Absence of anti-hepatitis B surface antibody after vaccination does not necessarily mean absence of immune response

A two dose combined hepatitis A and B vaccine in Chinese youngsters

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