“…[47,48,49]). For instance, to measure the dioxin-like activity, recombinant yeast cells, continuous teleostean and rodent cell lines and primary cell cultures from fish, birds and mammals have been used [50,51,52,53,54,55,56]. Differences of the gene induction response among cell systems derived from various species have been reported [53,54,57,58], which may relate to species-dependent ligandbinding affinity, in the expression level and structure of the receptors and their associated proteins, and in the ac-392 Fig.…”