Production of a broad palette of positron emitting radioisotopes using a low-energy cyclotron: Towards a new success story in cancer imaging?

Chakravarty, Rubel; Chakraborty, Sudipta

doi:10.1016/j.apradiso.2021.109860

Cited by 4 publications

(1 citation statement)

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“…Third, the resolution of the procedures will improve, as clinical PET imaging reaches a resolution of 4 to 6 mm, while SPECT imaging is typically between 8 and 12 mm [ 5 ]. Fourth, on-site production of PET radioisotopes is possible from both cyclotrons [ 6 ] and long-half-life radionuclide generators [ 7 ]. The non-availability of 99m Tc—for example, during the unplanned nuclear power plant shutdown of both the Petten reactor in the Netherlands and the NRU reactor in Canada in 2009—led to the loss of more than 50% of the global supply of this crucial radioisotope for several years, which was at that time used in more than 80% of all nuclear medicine procedures.…”

Section: Introductionmentioning

confidence: 99%

Preclinical PET Imaging and Toxicity Study of a 68Ga-Functionalized Polymeric Cardiac Blood Pool Agent

Saatchi

Bénard

Hundal³

et al. 2023

Pharmaceutics

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Cardiac blood pool imaging is currently performed almost exclusively with 99mTc-based compounds and SPECT/CT imaging. Using a generator-based PET radioisotope has a few advantages, including not needing nuclear reactors to produce it, obtaining better resolution in humans, and potentially reducing the radiation dose to the patient. When the shortlived radioisotope 68Ga is used, it can be applied repeatedly on the same day—for example, for the detection of bleeding. Our objective was to prepare and evaluate a long-circulating polymer functionalized with gallium for its biodistribution, toxicity, and dosimetric properties. A 500 kDa hyperbranched polyglycerol was conjugated to the chelator NOTA and radiolabeled rapidly at room temperature with 68Ga. It was then injected intravenously into a rat, and gated imaging allowed us to easily observe wall motion and cardiac contractility, confirming the suitability of this radiopharmaceutical for cardiac blood pool imaging. Internal radiation dose calculations showed that the radiation doses that patients would receive from the PET agent would be 2.5× lower than those from the 99mTc agent. A complete 14-day toxicology study in rats concluded that there were no gross pathology findings, changes in body or organ weights, or histopathological events. This radioactive-metal-functionalized polymer might be a suitable non-toxic agent to advance for clinical application.

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Section: Introductionmentioning

confidence: 99%